Ferrostatin-1 (Fer-1)
- Product Name
- Ferrostatin-1 (Fer-1)
- CAS No.
- 347174-05-4
- Chemical Name
- Ferrostatin-1 (Fer-1)
- Synonyms
- Fer1;Fer 1;Fer-1;SML0583-5MG;Ferrostatins-1;3-amino-4-(cycL;CCP.347174-05-4-G-1;Ferrostatin-1 (Fer-1);Fer-1 (Ferrostatin-1);Ferrostatin-1, 10 mM in DMSO
- CBNumber
- CB32484317
- Molecular Formula
- C15H22N2O2
- Formula Weight
- 262.35
- MOL File
- 347174-05-4.mol
Ferrostatin-1 (Fer-1) Property
- Boiling point:
- 437.3±35.0 °C(Predicted)
- Density
- 1.150±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: soluble10mg/mL, clear
- pka
- 4.78±0.11(Predicted)
- form
- powder
- color
- purple to brown
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
- InChI
- InChI=1S/C15H22N2O2/c1-2-19-15(18)11-8-9-14(13(16)10-11)17-12-6-4-3-5-7-12/h8-10,12,17H,2-7,16H2,1H3
- InChIKey
- UJHBVMHOBZBWMX-UHFFFAOYSA-N
- SMILES
- C(OCC)(=O)C1=CC=C(NC2CCCCC2)C(N)=C1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- SML0583
- Product name
- Ferrostatin-1
- Purity
- ≥95% (HPLC)
- Packaging
- 5mg
- Price
- $87.8
- Updated
- 2026/04/30
- Product number
- SML0583
- Product name
- Ferrostatin-1
- Purity
- ≥95% (HPLC)
- Packaging
- 25mg
- Price
- $357
- Updated
- 2026/04/30
- Product number
- F1302
- Product name
- Ferrostatin-1
- Packaging
- 25MG
- Price
- $150
- Updated
- 2026/04/30
- Product number
- F1302
- Product name
- Ferrostatin-1
- Packaging
- 100MG
- Price
- $376
- Updated
- 2026/04/30
- Product number
- 17729
- Product name
- Ferrostatin-1
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $61
- Updated
- 2026/04/30
Ferrostatin-1 (Fer-1) Chemical Properties,Usage,Production
Description
Ferrostatin-1 (347174-05-4) inhibits ferroptosis (EC50=60 nM), an iron-dependent form of nonapoptotic cell death.1Potent inhibitor of ferroptosis in cancer cells and glutamate-induced cell death in organotypic rat brain slices.1Blocks the cytotoxic effects of sorafenib in hepatocellular carcinoma cells.2Ferrostatin-1 inhibits oxidative lipid damage and cell death in diverse disease models3 and prevents apoptosis of renal proximal tubular cells induced by reactive oxygen species4.
Uses
Ferrostatin-1 (Fer-1) is a potent and selective inhibitor of ferroptosis.
Definition
ChEBI: Ferrostatin-1 is an ethyl ester resulting from the formal condensation of the carboxy group of 3-amino-4-(cyclohexylamino)benzoic acid with ethanol. It is a potent inhibitor of ferroptosis, a distinct non-apoptotic form of cell death caused by lipid peroxidation. It is also a radical-trapping antioxidant and has the ability to reduce the accumulation of lipid peroxides and chain-carrying peroxyl radicals. It has a role as a ferroptosis inhibitor, a radiation protective agent, an antioxidant, a radical scavenger, an antifungal agent and a neuroprotective agent. It is a substituted aniline, an ethyl ester and a primary arylamine.
Biochem/physiol Actions
Ferrostatin-1 is an active radical-trapping antioxidant that traps peroxyl radicals, and thus serves as a potential inhibitor of ferroptosis. Ferroptosis is considered as regulated necrosis, which differs from apoptosis and autophagy. Ferrostatin-1 is known to show protective effects against Huntington′s disease and also prevents neurotoxicity induced by glutamate in cellular models.
Synthesis
87815-77-8
347174-05-4
General procedure for the synthesis of ethyl 3-amino-4-(cyclohexylamino)benzoate from ethyl 4-(cyclohexylamino)-3-nitrobenzoate: the nitro derivative (24.28 g, 83 mmol) was dissolved in methanol (150 mL) and 20% Pd(OH)2/carbon catalyst (200 mg) was added. The hydrogenation reaction was carried out under hydrogen atmosphere at 1 atmosphere for 3 days. Upon completion of the reaction, the catalyst was removed by filtration followed by evaporation of the solvent under reduced pressure to afford the target product ethyl 3-amino-4-(cyclohexylamino)benzoate (21.72 g, 100% yield) as a dark purple solid.
storage
Store at +4°C
References
[1] SCOTT J DIXON. Ferroptosis: an iron-dependent form of nonapoptotic cell death.[J]. Cell, 2012, 149 5: 1060-1072. DOI:10.1016/j.cell.2012.03.042
[2] CHRISTOPHE LOUANDRE. Iron-dependent cell death of hepatocellular carcinoma cells exposed to sorafenib[J]. International Journal of Cancer, 2013, 133 7: 1732-1742. DOI:10.1002/ijc.28159
[3] RACHID SKOUTA. Ferrostatins Inhibit Oxidative Lipid Damage and Cell Death in Diverse Disease Models[J]. Journal of the American Chemical Society, 2014, 136 12: 4551-4556. DOI:10.1021/ja411006a
[4] GRAZYNA NOWAK Ruben M Sridharan Soundararajan. Protein kinase C-α interaction with iHSP70 in mitochondria promotes recovery of mitochondrial function after injury in renal proximal tubular cells.[J]. American Journal of Physiology-renal Physiology, 2013, 305 5: F764-76. DOI:10.1152/ajprenal.00061.2013
Ferrostatin-1 (Fer-1) Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Ferrostatin-1 (Fer-1) manufacturers
- Product
- Ferrostatin-1 (Fer-1) 347174-05-4
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99.99%
- Supply Ability
- 200kg
- Release date
- 2019-12-20