5-Iodo-2-thiophenecarbonitrile
- Product Name
- 5-Iodo-2-thiophenecarbonitrile
- CAS No.
- 18945-81-8
- Chemical Name
- 5-Iodo-2-thiophenecarbonitrile
- Synonyms
- 5-iodothiophene-2-carbonitrile;5-Iodo-2-thiophenecarbonitrile;2-Thiophenecarbonitrile, 5-iodo-
- CBNumber
- CB32489998
- Molecular Formula
- C5H2INS
- Formula Weight
- 235.05
- MOL File
- 18945-81-8.mol
5-Iodo-2-thiophenecarbonitrile Property
- Density
- 2.14
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- InChI
- InChI=1S/C5H2INS/c6-5-2-1-4(3-7)8-5/h1-2H
- InChIKey
- DCTRQPYCGCNWBN-UHFFFAOYSA-N
- SMILES
- C1(C#N)SC(I)=CC=1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P322Specific measures (see …on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P363Wash contaminated clothing before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 9875AA
- Product name
- 5-Iodothiophene-2-carbonitrile
- Packaging
- 250mg
- Price
- $286
- Updated
- 2021/12/16
- Product number
- 096853
- Product name
- 5-Iodothiophene-2-carbonitrile
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $416
- Updated
- 2021/12/16
- Product number
- HCH0367504
- Product name
- 5-IODOTHIOPHENE-2-CARBONITRILE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $505.42
- Updated
- 2021/12/16
- Product number
- 9875AA
- Product name
- 5-Iodothiophene-2-carbonitrile
- Packaging
- 1g
- Price
- $639
- Updated
- 2021/12/16
- Product number
- 096853
- Product name
- 5-Iodothiophene-2-carbonitrile
- Purity
- 95+%
- Packaging
- 1g
- Price
- $924
- Updated
- 2021/12/16
5-Iodo-2-thiophenecarbonitrile Chemical Properties,Usage,Production
Synthesis
1003-31-2
18945-81-8
Under nitrogen protection, 2-cyanothiophene (1 mmol) was dissolved in anhydrous THF (1.5 mL) in a flame-dried flask. TMPMgCl-LiCl (1.0 M solution of THF, 1.8 mL, 1.8 mmol) was slowly added dropwise at 25 °C and the reaction mixture was stirred for 2 h (for substrate 1a, it is recommended that the metallization time be kept within 1 h). The completion of the metallization reaction was monitored by GC analysis, and an aliquot of the reaction solution was taken and quenched with anhydrous THF solution of iodine (I2) to terminate the reaction. Subsequently, a solution of anhydrous THF (2 mL) with electrophilic reagent (2 mmol) was slowly added dropwise at 0 °C, and the temperature was raised to 25 °C to continue stirring for 1 hour. Upon completion of the reaction, the reaction was quenched with saturated aqueous NaHCO3 solution. Extraction was carried out sequentially with NaHSO3 or NH4Cl solution (5 mL) and ethyl acetate (3 x 15 mL), the organic phases were combined and dried with anhydrous MgSO4. After filtration to remove the desiccant, the solvent was removed by distillation under reduced pressure to give the crude product 5-iodothiophene-2-carbonitrile.
References
[1] Synlett, 2015, vol. 26, # 20, p. 2795 - 2800
[2] Tetrahedron Letters, 1995, vol. 36, # 27, p. 4883 - 4884
5-Iodo-2-thiophenecarbonitrile Preparation Products And Raw materials
Raw materials
Preparation Products
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