2-Hydroxy-5-iodo-3-nitropyridine

Product Name: 2-Hydroxy-5-iodo-3-nitropyridine
CAS No.: 25391-59-7
Chemical Name: 2-Hydroxy-5-iodo-3-nitropyridine
Synonyms: 5-IODO-3-NITROPYRIDIN-2-OL;5-Iodo-3-nitropyridin-2(1H)-one;2-Hydroxy-3-nitro-5-iodopyridine;2-Hydroxy-5-iodo-3-nitropyridine;2(1H)-Pyridinone, 5-iodo-3-nitro-
CBNumber: CB31471141
Molecular Formula: C5H3IN2O3
Formula Weight: 265.99
MOL File: 25391-59-7.mol

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2-Hydroxy-5-iodo-3-nitropyridine Property

Melting point:: 252-256°C
Boiling point:: 314.0±42.0 °C(Predicted)
Density: 2.27±0.1 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
pka: 6.50±0.10(Predicted)
Appearance: Light yellow to yellow Solid

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 22-36/37/38
Safety Statements: 26-36/37
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 701459
Product name: 2-Hydroxy-5-iodo-3-nitropyridine
Purity: 97%
Packaging: 1g
Price: $108
Updated: 2023/06/20

TRC

Product number: I715715
Product name: 5-Iodo-3-nitropyridin-2-ol
Packaging: 50mg
Price: $45
Updated: 2021/12/16

TRC

Product number: I715715
Product name: 5-Iodo-3-nitropyridin-2-ol
Packaging: 100mg
Price: $60
Updated: 2021/12/16

TRC

Product number: I715715
Product name: 5-Iodo-3-nitropyridin-2-ol
Packaging: 500mg
Price: $90
Updated: 2021/12/16

AK Scientific

Product number: 8470AD
Product name: 5-Iodo-3-nitropyridin-2-ol
Packaging: 1g
Price: $105
Updated: 2021/12/16

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2-Hydroxy-5-iodo-3-nitropyridine Chemical Properties,Usage,Production

Synthesis

6332-56-5

25391-59-7

3-Nitropyridin-2(1H)-one (10.3 g, 73.4 mmol, 1 eq.) was used as a raw material and suspended in a mixed solution of 46 mL acetic acid, 20 mL water, 1.4 mL concentrated sulfuric acid and periodate (3.5 g, 18 mmol, 0.25 eq.). The reaction mixture was stirred at 90 °C for 15 min until completely dissolved. Subsequently, iodine crystals (7.7 g, 30.1 mmol, 0.4 eq.) were added in batches and formation of a dense yellow precipitate was observed after 20 min of reaction. The reaction mixture was cooled to room temperature and 50 mL of saturated sodium thiosulfate solution was added to quench the reaction. The solid product was collected by filtration and washed sequentially with 50 mL of saturated sodium thiosulfate solution and water. Finally, the solid was dried under vacuum to give 5-iodo-3-nitropyridin-2-ol (XIII-2, 14 g, 72% yield).

References

[1] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 12, p. 3973 - 3977
[2] Journal of Medicinal Chemistry, 2009, vol. 52, # 19, p. 5785 - 5788
[3] Patent: US2014/94456, 2014, A1. Location in patent: Paragraph 0656-0657
[4] Patent: WO2015/153683, 2015, A1. Location in patent: Paragraph 0413
[5] Bioorganic & Medicinal Chemistry Letters, 2003, vol. 13, # 3, p. 525 - 528

2-Hydroxy-5-iodo-3-nitropyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Hydroxy-5-iodo-3-nitropyridine Suppliers

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25391-59-7, 2-Hydroxy-5-iodo-3-nitropyridineRelated Search:

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2-Hydroxy-5-iodo-3-nitropyridine

5-IODO-3-NITROPYRIDIN-2-OL

5-Iodo-3-nitropyridin-2(1H)-one

2-Hydroxy-3-nitro-5-iodopyridine

2(1H)-Pyridinone, 5-iodo-3-nitro-

25391-59-7