ChemicalBook > CAS DataBase List > 2-Hydroxy-5-iodo-3-nitropyridine

2-Hydroxy-5-iodo-3-nitropyridine

Product Name
2-Hydroxy-5-iodo-3-nitropyridine
CAS No.
25391-59-7
Chemical Name
2-Hydroxy-5-iodo-3-nitropyridine
Synonyms
5-IODO-3-NITROPYRIDIN-2-OL;5-Iodo-3-nitropyridin-2(1H)-one;2-Hydroxy-3-nitro-5-iodopyridine;2-Hydroxy-5-iodo-3-nitropyridine;2(1H)-Pyridinone, 5-iodo-3-nitro-
CBNumber
CB31471141
Molecular Formula
C5H3IN2O3
Formula Weight
265.99
MOL File
25391-59-7.mol
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2-Hydroxy-5-iodo-3-nitropyridine Property

Melting point:
252-256°C
Boiling point:
314.0±42.0 °C(Predicted)
Density 
2.27±0.1 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
pka
6.50±0.10(Predicted)
Appearance
Light yellow to yellow Solid
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
22-36/37/38
Safety Statements 
26-36/37
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
701459
Product name
2-Hydroxy-5-iodo-3-nitropyridine
Purity
97%
Packaging
1g
Price
$108
Updated
2023/06/20
TRC
Product number
I715715
Product name
5-Iodo-3-nitropyridin-2-ol
Packaging
50mg
Price
$45
Updated
2021/12/16
TRC
Product number
I715715
Product name
5-Iodo-3-nitropyridin-2-ol
Packaging
100mg
Price
$60
Updated
2021/12/16
TRC
Product number
I715715
Product name
5-Iodo-3-nitropyridin-2-ol
Packaging
500mg
Price
$90
Updated
2021/12/16
AK Scientific
Product number
8470AD
Product name
5-Iodo-3-nitropyridin-2-ol
Packaging
1g
Price
$105
Updated
2021/12/16
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2-Hydroxy-5-iodo-3-nitropyridine Chemical Properties,Usage,Production

Synthesis

6332-56-5

25391-59-7

3-Nitropyridin-2(1H)-one (10.3 g, 73.4 mmol, 1 eq.) was used as a raw material and suspended in a mixed solution of 46 mL acetic acid, 20 mL water, 1.4 mL concentrated sulfuric acid and periodate (3.5 g, 18 mmol, 0.25 eq.). The reaction mixture was stirred at 90 °C for 15 min until completely dissolved. Subsequently, iodine crystals (7.7 g, 30.1 mmol, 0.4 eq.) were added in batches and formation of a dense yellow precipitate was observed after 20 min of reaction. The reaction mixture was cooled to room temperature and 50 mL of saturated sodium thiosulfate solution was added to quench the reaction. The solid product was collected by filtration and washed sequentially with 50 mL of saturated sodium thiosulfate solution and water. Finally, the solid was dried under vacuum to give 5-iodo-3-nitropyridin-2-ol (XIII-2, 14 g, 72% yield).

References

[1] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 12, p. 3973 - 3977
[2] Journal of Medicinal Chemistry, 2009, vol. 52, # 19, p. 5785 - 5788
[3] Patent: US2014/94456, 2014, A1. Location in patent: Paragraph 0656-0657
[4] Patent: WO2015/153683, 2015, A1. Location in patent: Paragraph 0413
[5] Bioorganic & Medicinal Chemistry Letters, 2003, vol. 13, # 3, p. 525 - 528

2-Hydroxy-5-iodo-3-nitropyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Hydroxy-5-iodo-3-nitropyridine Suppliers

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25391-59-7, 2-Hydroxy-5-iodo-3-nitropyridineRelated Search:

5-IODO-1H-PYRROLO[2,3-B]PYRIDINE 5-Iodo-7H-pyrrolo[2,3-d]pyrimidine 5-Iodo-2-thiophenecarbonitrile 5-IODO-6-HYDROXY-2-METHYLTHIO-PYRIMIDINE 5-IODO-1-METHYL-1H-PYRAZOLE 5-Iodo-3-(trifluoromethyl)-2-pyridinamine 5-Iodo-2-(piperazin-1-yl)pyrimidine 5-IODO-2-METHOXYBENZALDEHYDE 5-Iodo-3-methyl-1H-pyrazole 5-Iodo-2-Methoxy-3-Methylpyridine 5-Iodo-4-methylpyrimidine 5-IODO-2-METHOXYANILINE 5-iodo-4-(trifluoroMethyl)thiazol-2-aMine 5-IODO-2-METHOXY-3-(TRIFLUOROMETHYL)-PYRIDINONE 2-Hydroxy-5-iodo-3-methylpyridine 5-IODO-PYRIDIN-3-YLAMINE 2-Hydroxy-5-iodopyridine 2-Hydroxy-5-iodo-3-nitropyridine

  • 2-Hydroxy-5-iodo-3-nitropyridine
  • 5-IODO-3-NITROPYRIDIN-2-OL
  • 5-Iodo-3-nitropyridin-2(1H)-one
  • 2-Hydroxy-3-nitro-5-iodopyridine
  • 2(1H)-Pyridinone, 5-iodo-3-nitro-
  • 25391-59-7