5-IODO-2-METHOXYANILINE
- Product Name
- 5-IODO-2-METHOXYANILINE
- CAS No.
- 77770-09-3
- Chemical Name
- 5-IODO-2-METHOXYANILINE
- Synonyms
- 5-IODO-O-ANISIDINE;2-amino-4-iodoanisole;5-IODO-2-METHOXYANILINE;5-iodine-2-methoxyaniline;5-Iodo-2-methoxyaniline,97%;BenzenaMine, 5-iodo-2-Methoxy-;4-Methoxy-3-amino-1-iodobenzene;2-Amino-4-iodoanisole, 5-Iodo-o-anisidine;2-AMino-4-iodoanisole[5-Iodo-2-Methoxyaniline]
- CBNumber
- CB0473093
- Molecular Formula
- C7H8INO
- Formula Weight
- 249.05
- MOL File
- 77770-09-3.mol
5-IODO-2-METHOXYANILINE Property
- Melting point:
- 85-87°C
- Boiling point:
- 304.3±32.0 °C(Predicted)
- Density
- 1.807±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 3.58±0.10(Predicted)
- Appearance
- Yellow to brown Solid
- Water Solubility
- Sparingly soluble in water 0.87 g/L @ 25°C.
- Sensitive
- Light Sensitive
- CAS DataBase Reference
- 77770-09-3
Safety
- Risk Statements
- 20/21/22-36/37/38
- Safety Statements
- 26-36/37/39
- HS Code
- 2922290090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H301Toxic if swalloed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- 4656-H-05
- Product name
- 5-Iodo-2-methoxyaniline
- Purity
- 98%
- Packaging
- 5G
- Price
- $141
- Updated
- 2021/12/16
- Product number
- X5382
- Product name
- 5-iodo-2-methoxyaniline
- Packaging
- 5g
- Price
- $200
- Updated
- 2021/12/16
- Product number
- HCH0024959
- Product name
- 5-IODO-2-METHOXYANILINE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $654.89
- Updated
- 2021/12/16
- Product number
- HCH0024959
- Product name
- 5-IODO-2-METHOXYANILINE
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $965.35
- Updated
- 2021/12/16
- Product number
- 61-3212
- Product name
- 2-Amino-4-iodoanisole
- Purity
- 95+%
- Packaging
- 1g
- Price
- $45
- Updated
- 2021/12/16
5-IODO-2-METHOXYANILINE Chemical Properties,Usage,Production
Uses
5-Iodo-2-methoxyaniline is used as a pharmaceutical intermediate.
Synthesis
52692-09-8
77770-09-3
GENERAL STEPS: To a dry round-bottomed flask fitted with a magnetic stirrer, a mixed solution of ethanol (75 mL) and ethyl acetate (30 mL) of 4-iodo-2-nitroanisole (16.2 g, 58 mmol) and tin(II) chloride dihydrate (65.5 g, 290 mmol) was added under nitrogen protection. The reaction mixture was heated and stirred at 70°C for 30 minutes. Subsequently, about half of the solvent was removed by evaporation and ether (100 mL) was added. The mixture was allowed to stand overnight in a refrigerator. The precipitate precipitated was collected by filtration and washed with ether. The resulting solid was dissolved in 15% aqueous sodium hydroxide solution (150 mL) and cooled in an ice bath. The mixture was extracted with dichloromethane, and the organic layer was sequentially washed with saturated brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure to give 5-iodo-2-methoxyaniline (9.5 g, 38 mmol, 66% yield) as a white solid.
References
[1] Synlett, 2012, vol. 23, # 8, p. 1205 - 1208
[2] Synlett, 2013, vol. 24, # 14, p. 1772 - 1776
[3] Russian Chemical Bulletin, 2013, vol. 62, # 4, p. 1103 - 1110
[4] Izv. Akad. Nauk, Ser. Khim., 2013, # 4, p. 1102 - 1110,9
[5] Journal of the Chemical Society, 1916, vol. 109, p. 1087
5-IODO-2-METHOXYANILINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-IODO-2-METHOXYANILINE manufacturers
- Product
- 5-IODO-2-METHOXYANILINE 77770-09-3
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
- Product
- 5-IODO-2-METHOXYANILINE 77770-09-3
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-09
- Product
- 5-IODO-2-METHOXYANILINE 77770-09-3
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 96%-98%
- Supply Ability
- 1000KGS
- Release date
- 2019-12-24