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5-IODO-2-METHOXYANILINE

Product Name
5-IODO-2-METHOXYANILINE
CAS No.
77770-09-3
Chemical Name
5-IODO-2-METHOXYANILINE
Synonyms
5-IODO-O-ANISIDINE;2-amino-4-iodoanisole;5-IODO-2-METHOXYANILINE;5-iodine-2-methoxyaniline;5-Iodo-2-methoxyaniline,97%;BenzenaMine, 5-iodo-2-Methoxy-;4-Methoxy-3-amino-1-iodobenzene;2-Amino-4-iodoanisole, 5-Iodo-o-anisidine;2-AMino-4-iodoanisole[5-Iodo-2-Methoxyaniline]
CBNumber
CB0473093
Molecular Formula
C7H8INO
Formula Weight
249.05
MOL File
77770-09-3.mol
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5-IODO-2-METHOXYANILINE Property

Melting point:
85-87°C
Boiling point:
304.3±32.0 °C(Predicted)
Density 
1.807±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
pka
3.58±0.10(Predicted)
Appearance
Yellow to brown Solid
Water Solubility 
Sparingly soluble in water 0.87 g/L @ 25°C.
Sensitive 
Light Sensitive
CAS DataBase Reference
77770-09-3
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Safety

Risk Statements 
20/21/22-36/37/38
Safety Statements 
26-36/37/39
HS Code 
2922290090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

AK Scientific
Product number
X5382
Product name
5-iodo-2-methoxyaniline
Packaging
5g
Price
$200
Updated
2021/12/16
SynQuest Laboratories
Product number
4656-H-05
Product name
5-Iodo-2-methoxyaniline
Purity
98%
Packaging
5G
Price
$141
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0024959
Product name
5-IODO-2-METHOXYANILINE
Purity
95.00%
Packaging
1G
Price
$654.89
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0024959
Product name
5-IODO-2-METHOXYANILINE
Purity
95.00%
Packaging
5G
Price
$965.35
Updated
2021/12/16
Alichem
Product number
77770093
Product name
2-Amino-4-iodoanisole
Packaging
1g
Price
$1460.2
Updated
2021/12/16
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5-IODO-2-METHOXYANILINE Chemical Properties,Usage,Production

Uses

5-Iodo-2-methoxyaniline is used as a pharmaceutical intermediate.

Synthesis

52692-09-8

77770-09-3

GENERAL STEPS: To a dry round-bottomed flask fitted with a magnetic stirrer, a mixed solution of ethanol (75 mL) and ethyl acetate (30 mL) of 4-iodo-2-nitroanisole (16.2 g, 58 mmol) and tin(II) chloride dihydrate (65.5 g, 290 mmol) was added under nitrogen protection. The reaction mixture was heated and stirred at 70°C for 30 minutes. Subsequently, about half of the solvent was removed by evaporation and ether (100 mL) was added. The mixture was allowed to stand overnight in a refrigerator. The precipitate precipitated was collected by filtration and washed with ether. The resulting solid was dissolved in 15% aqueous sodium hydroxide solution (150 mL) and cooled in an ice bath. The mixture was extracted with dichloromethane, and the organic layer was sequentially washed with saturated brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure to give 5-iodo-2-methoxyaniline (9.5 g, 38 mmol, 66% yield) as a white solid.

References

[1] Synlett, 2012, vol. 23, # 8, p. 1205 - 1208
[2] Synlett, 2013, vol. 24, # 14, p. 1772 - 1776
[3] Russian Chemical Bulletin, 2013, vol. 62, # 4, p. 1103 - 1110
[4] Izv. Akad. Nauk, Ser. Khim., 2013, # 4, p. 1102 - 1110,9
[5] Journal of the Chemical Society, 1916, vol. 109, p. 1087

5-IODO-2-METHOXYANILINE Preparation Products And Raw materials

Raw materials

Preparation Products

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5-IODO-2-METHOXYANILINE Suppliers

China 83 Germany 2 India 5 United Kingdom 6 United States 6 Global 102
GLR Innovations
Tel
+91 9891111994
Email
info@glrgroup.in
Country
India
ProdList
4535
Advantage
58
A.J Chemicals
Tel
--
Fax
--
Email
sales@ajchem.in
Country
India
ProdList
6100
Advantage
58
CHEMSWORTH
Tel
--
Fax
--
Email
info@chemsworth.com
Country
India
ProdList
6700
Advantage
30
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View Lastest Price from 5-IODO-2-METHOXYANILINE manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
5-IODO-2-METHOXYANILINE 77770-09-3
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
5-IODO-2-METHOXYANILINE 77770-09-3
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-09
Career Henan Chemical Co
Product
5-IODO-2-METHOXYANILINE 77770-09-3
Price
US $1.00/g
Min. Order
1g
Purity
96%-98%
Supply Ability
1000KGS
Release date
2019-12-24

77770-09-3, 5-IODO-2-METHOXYANILINERelated Search:

5-IODO-2-METHOXYANILINE 4-Iodo-2-nitroanisole 4-Iodoanisole 2-iodo-4-methoxyaniline 6-IODO-3,4-DIHYDRO-2H-BENZO[B][1,4]OXAZINE 3-IODO-5-METHOXYANILINE 4-IODO-3-METHOXYANILINE HYDROCHLORIDE 3-IODO-4-METHOXYANILINE HYDROCHLORIDE,3-Iodo-4-methoxyaniline HCl 2-Iodo-3-methoxyaniline 4-Iodo-2-methoxyaniline 2-IODO-5-METHOXYANILINE 3-IODO-4-METHOXYANILINE,3-Iodo-p-anisidine BUTTPARK 120\07-78 3-(4-FLUOROBENZOYL)-5,7-DIIODO-1,3-BENZOXAZOL-2(3H)-ONE 6-IODO-3,4-DIHYDRO-2H-BENZO[1,4]OXAZINE HYDROCHLORIDE 5,7-DIIODO-1,3-BENZOXAZOL-2(3H)-ONE 5,7-DIIODO-3-[4-(TRIFLUOROMETHYL)BENZOYL]-1,3-BENZOXAZOL-2(3H)-ONE 5,7-DIIODO-3-(4-METHOXYBENZOYL)-1,3-BENZOXAZOL-2(3H)-ONE

  • 5-Iodo-2-methoxyaniline,97%
  • 5-IODO-2-METHOXYANILINE
  • 5-IODO-O-ANISIDINE
  • 2-amino-4-iodoanisole
  • BenzenaMine, 5-iodo-2-Methoxy-
  • 2-Amino-4-iodoanisole, 5-Iodo-o-anisidine
  • 2-AMino-4-iodoanisole[5-Iodo-2-Methoxyaniline]
  • 4-Methoxy-3-amino-1-iodobenzene
  • 5-iodine-2-methoxyaniline
  • 77770-09-3
  • 7770-09-3
  • C7H8INO