2-Amino-5-bromo-3-(trifluoromethyl)pyridine

Application

Product Name: 2-Amino-5-bromo-3-(trifluoromethyl)pyridine
CAS No.: 79456-34-1
Chemical Name: 2-Amino-5-bromo-3-(trifluoromethyl)pyridine
Synonyms: 2-Amino-3-trifluoro-5-bromopyridine;5-Bromo-3-(trifluoromethyl)-2-pyridinamine;5-BROMO-3-(TRIFLUOROMETHYLl)PYRIDIN-2-AMINE;2-Amino-5-bromo-3-(trifluoromethyl)pyridine;2-Pyridinamine, 5-bromo-3-(trifluoromethyl)-;2-Amino-5-bromo-3-(trifluoromethyl)pyridine,96%;2-Amino-5-bromo-3-(trifluoromethyl)pyridine ISO 9001：2015 REACH;5-Bromo-3-(trifluoromethyl)pyridin-2-amine, 2-Amino-5-bromo-alpha,alpha,alpha-trifluoro-3-picoline
CBNumber: CB32500758
Molecular Formula: C6H4BrF3N2
Formula Weight: 241.01
MOL File: 79456-34-1.mol

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2-Amino-5-bromo-3-(trifluoromethyl)pyridine Property

Melting point:: 90 °C
Boiling point:: 216.6±35.0 °C(Predicted)
Density: 1.790±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
pka: 1.93±0.49(Predicted)
form: powder to crystal
color: White to Almost white
InChI: InChI=1S/C6H4BrF3N2/c7-3-1-4(6(8,9)10)5(11)12-2-3/h1-2H,(H2,11,12)
InChIKey: QUYZBNHTYCLZLW-UHFFFAOYSA-N
SMILES: C1(N)=NC=C(Br)C=C1C(F)(F)F

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Safety

RIDADR: UN2811
HazardClass: IRRITANT
HS Code: 2933599590

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical

Product number: A3139
Product name: 2-Amino-5-bromo-3-(trifluoromethyl)pyridine
Packaging: 1G
Price: $86
Updated: 2026/04/30

AstaTech

Product number: 51735
Product name: 5-BROMO-3-(TRIFLUOROMETHYL)PYRIDIN-2-AMINE
Purity: 97%
Packaging: 1G
Price: $19
Updated: 2026/04/30

AstaTech

Product number: 51735
Product name: 5-BROMO-3-(TRIFLUOROMETHYL)PYRIDIN-2-AMINE
Purity: 97%
Packaging: 5G
Price: $37
Updated: 2026/04/30

AstaTech

Product number: 51735
Product name: 5-BROMO-3-(TRIFLUOROMETHYL)PYRIDIN-2-AMINE
Purity: 97%
Packaging: 25G
Price: $129
Updated: 2026/04/30

Matrix Scientific

Product number: 046779
Product name: 5-Bromo-3-(trifluoromethyl)-2-pyridinylamine
Purity: 95+%
Packaging: 5g
Price: $146
Updated: 2021/12/16

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2-Amino-5-bromo-3-(trifluoromethyl)pyridine Chemical Properties,Usage,Production

Application

2-Amino-3-trifluoromethyl-5-bromopyridine is an organic intermediate that can be obtained by brominating 2-amino-3-trifluoromethylpyridine.

Synthesis

183610-70-0

79456-34-1

Step 3) Synthesis of 5-bromo-3-trifluoromethylpyridin-2-ylamine (CAS No. [79456-34-1]): 3-trifluoromethylpyridin-2-ylamine (16.21 g, 100 mmol) was dissolved in acetonitrile (300 mL) at 5 °C and N-bromosuccinimide (NBS, 17.8 g, 100 mmol) was added slowly. The reaction mixture was warmed up to 23 °C with continuous stirring for 1 hour. Upon completion of the reaction, the mixture was quenched by pouring it into ice. The reaction mixture was extracted with ethyl acetate (EtOAc) and the organic phase was washed sequentially with saturated sodium bicarbonate (NaHCO3) solution and brine and dried over anhydrous sodium sulfate (Na2SO4). The solvent was removed by concentration under reduced pressure to give a yellow solid crude product. The crude product was purified by silica gel column chromatography using dichloromethane as eluent to give 2-amino-3-trifluoromethyl-5-bromopyridine as yellow solid (23.71 g, 98% yield). Mass spectrometry (EI) showed molecular ion peaks of 240.1 [M]+ and 242.0 [M+2]+.

References

[1] Patent: US2007/72879, 2007, A1. Location in patent: Page/Page column 18
[2] Patent: WO2010/8847, 2010, A2. Location in patent: Page/Page column 147
[3] Patent: CN105732602, 2016, A. Location in patent: Paragraph 0364; 0366; 0367; 0368; 0369
[4] Patent: WO2009/23179, 2009, A2. Location in patent: Page/Page column 196-197
[5] Patent: WO2015/158427, 2015, A1. Location in patent: Page/Page column 87; 88

2-Amino-5-bromo-3-(trifluoromethyl)pyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Amino-5-bromo-3-(trifluoromethyl)pyridine Suppliers

Americas 1 China 122 Europe 1 India 4 Japan 1 Switzerland 2 United Kingdom 3 United States 13 Global 147

Changzhou Jienuo Pharmaceutical Technology Co., Ltd

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View Lastest Price from 2-Amino-5-bromo-3-(trifluoromethyl)pyridine manufacturers

Dideu Industries Group Limited

Product: 2-Amino-5-bromo-3-(trifluoromethyl)pyridine 79456-34-1
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons min
Release date: 2021-08-23

Shaanxi Dideu Medichem Co. Ltd

Product: 2-Amino-5-bromo-3-(trifluoromethyl)pyridine 79456-34-1
Price: US $0.00-0.00/Kg
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 500 MT
Release date: 2020-05-12

Career Henan Chemical Co

Product: 2-Amino-5-bromo-3-(trifluoromethyl)pyridine 79456-34-1
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2019-12-30

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2-Amino-5-bromo-3-(trifluoromethyl)pyridine ISO 9001：2015 REACH

79456-34-1