R788(Fostamatinib disodium)

Product Name: R788(Fostamatinib disodium)
CAS No.: 1025687-58-4
Chemical Name: R788(Fostamatinib disodium)
Synonyms: FosD;R 788 sodium;R788 disodium;R 935788 sodium;prodrug of R-406;Tamatinib Fosdium;Fo(R788) disodium;R788, Fostamatinib;R788 (sodium salt);FostaMatinib sodiuM
CBNumber: CB32518272
Molecular Formula: C23H27FN6NaO9P
Formula Weight: 604.46
MOL File: 1025687-58-4.mol

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R788(Fostamatinib disodium) Property

Melting point:: >191°C (dec.)
storage temp.: Store at -20°C
solubility: DMSO (Slightly), Methanol (Slightly)
form: Solid
color: Off-White
Stability:: Hygroscopic

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 18501
Product name: R788 (sodium salt)
Purity: ≥95%
Packaging: 1mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 18501
Product name: R788 (sodium salt)
Purity: ≥95%
Packaging: 5mg
Price: $193
Updated: 2024/03/01

Cayman Chemical

Product number: 18501
Product name: R788 (sodium salt)
Purity: ≥95%
Packaging: 10mg
Price: $341
Updated: 2024/03/01

ChemScene

Product number: CS-0427
Product name: FostamatinibDisodium
Purity: 99.88%
Packaging: 5mg
Price: $96
Updated: 2021/12/16

ChemScene

Product number: CS-0427
Product name: FostamatinibDisodium
Purity: 99.88%
Packaging: 10mg
Price: $144
Updated: 2021/12/16

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R788(Fostamatinib disodium) Chemical Properties,Usage,Production

Uses

R 788 Sodium Salt is the sodium salt of R 788 which is a selective spleen tyrosine kinase (Syk) inhibitor. It may be used in the treatment of autoimmune diseases such as type 1 diabetes and has been tested in the treatment of rheumatoid athritis, leukemia and lymphoma.

Biological Activity

r788, which is the prodrug of r406, is a potnet and selective syk inhibitor. the spleen tyrosine kinase (syk) plays a key role in the signaling of activating fc receptors and the b-cell receptor (bcr).

in vitro

r406 was found to induce the apoptosis of the majority of examined dlbcl cell lines and could specifically inhibit both tonic- and ligand-induced bcr signaling (autophosphorylation of syk525/526 and sykdependent phosphorylation of the b-cell linker protein [blnk]) [1].

in vivo

r788 effectively inhibits bcr signaling, demonstrating reduced proliferation and survival of the malignant b cells and significantly prolonged survival of the treated eμ-tcl1 transgenic mouse. moreover, the effect of r788 was found to be selective for the malignant clones, since no disturbance in the production of normal b lymphocytes was observed [2].

target

Syk

References

[1] chen l, monti s, juszczynski p, daley j, chen w, witzig te, habermann tm, kutok jl, shipp ma. syk-dependent tonic b-cell receptor signaling is a rational treatment target in diffuse large b-cell lymphoma. blood. 2008 feb 15;111(4):2230-7.
[2] suljagic m, longo pg, bennardo s, perlas e, leone g, laurenti l, efremov dg. the syk inhibitor fostamatinib disodium (r788) inhibits tumor growth in the eμ- tcl1 transgenic mouse model of cll by blocking antigen-dependent b-cell receptor signaling. blood. 2010 dec 2;116(23):4894-905.
[3] bajpai m. fostamatinib, a syk inhibitor prodrug for the treatment of inflammatory diseases. idrugs. 2009 mar;12(3):174-85.

R788(Fostamatinib disodium) Preparation Products And Raw materials

Raw materials

Preparation Products

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R788(Fostamatinib disodium) Suppliers

China 108 India 2 United Kingdom 1 United States 15 Global 126

Shanghai Boyle Chemical Co., Ltd.

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SYN|thesis med chem P/L

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View Lastest Price from R788(Fostamatinib disodium) manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: Fostamatinib disodium 1025687-58-4
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-06-26

Career Henan Chemical Co

Product: R788(Fostamatinib disodium) 1025687-58-4
Price: US $3.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100kg
Release date: 2019-08-06

1025687-58-4, R788(Fostamatinib disodium)Related Search:

Baricitinib Selumetinib Indacaterol Maleate BI 2536 Ibrutinib LY 294002 HYDROCHLORIDE

R788(Fostamatinib disodium)

R788, Fostamatinib

R935788 (FostaMatinib disodiuM)

FosD

FOSTAMATINIB;FOSD;TAMATINIB FOSDIUM

Tamatinib Fosdium

R788(prodrug of R406)

R935788 (FostaMatinib disodiuM, R788)

6-[[5-Fluoro-2-[(3,4,5-trimethoxyphenyl)amino]-4-pyrimidinyl]amino]-2,2-dimethyl-4-[(phosphonooxy)methyl]-2H-pyrido[3,2-b]-1,4-oxazin-3(4H)-one sodium salt

R788; R-935788;R 788 SODIUM;FOSD

R788 disodium (Fostamatinib)

R788; FOSTAMATINIB;R-788

sodium (6-((5-fluoro-2-((3,4,5-trimethoxyphenyl)amino)pyrimidin-4-yl)amino)-2,2-dimethyl-3-oxo-2H-pyrido[3,2-b][1,4]oxazin-4(3H)-yl)methyl phosphate

R788 disodium, >=98%

R788 disodium

R788(prodrug of R46)

R788 (sodium salt)

Disodium (6-(5-fluoro-2-(3,4,5-trimethoxyphenylamino)pyrimidin-4-ylamino)-2,2-dimethyl-3-oxo-2

R 788 sodium

R 935788 sodium

FostaMatinib sodiuM

Fostamatinib/R788 disodium)

2H-Pyrido[3,2-b]-1,4-oxazin-3(4H)-one, 6-[[5-fluoro-2-[(3,4,5-trimethoxyphenyl)amino]-4-pyrimidinyl]amino]-2,2-dimethyl-4-[(phosphonooxy)methyl]-, sodium salt (1:2)

6-[[5-Fluoro-2-[(3,4,5-trimethoxyphenyl)amino]-4-pyrimidinyl]amino]-2,2-dimethyl-4-[(phosphonooxy)methyl]-2H-pyrido[3,2-b]-1,4-oxazin-3(4H)-one sodium salt R788 (Fostamatinib) Disodium R 935788 sodium

Fostamatinib disodium R 788 sodium

R788(Fostamatinib disodium) USP/EP/BP

R 788 Sodium Salt DISCONTINUED. Please see R070115.

Fostamatinib Disodium (R788

Fo(R788) disodium

prodrug of R-406

1025687-58-4

C23H24FN6Na2O9P

C23H24FN6O9P2Na

Inhibitors