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R788(Fostamatinib disodium)

Product Name
R788(Fostamatinib disodium)
CAS No.
1025687-58-4
Chemical Name
R788(Fostamatinib disodium)
Synonyms
FosD;R 788 sodium;R788 disodium;R 935788 sodium;prodrug of R-406;Tamatinib Fosdium;Fo(R788) disodium;R788, Fostamatinib;R788 (sodium salt);FostaMatinib sodiuM
CBNumber
CB32518272
Molecular Formula
C23H27FN6NaO9P
Formula Weight
604.46
MOL File
1025687-58-4.mol
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R788(Fostamatinib disodium) Property

Melting point:
>191°C (dec.)
storage temp. 
Store at -20°C
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
color 
Off-White
Stability:
Hygroscopic
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
18501
Product name
R788 (sodium salt)
Purity
≥95%
Packaging
1mg
Price
$44
Updated
2024/03/01
Cayman Chemical
Product number
18501
Product name
R788 (sodium salt)
Purity
≥95%
Packaging
5mg
Price
$193
Updated
2024/03/01
Cayman Chemical
Product number
18501
Product name
R788 (sodium salt)
Purity
≥95%
Packaging
10mg
Price
$341
Updated
2024/03/01
Adipogen Life Sciences
Product number
SYN-1122-M010
Product name
R788disodiumsalt
Purity
≥95%
Packaging
10mg
Price
$324
Updated
2021/12/16
ChemScene
Product number
CS-0427
Product name
FostamatinibDisodium
Purity
99.88%
Packaging
5mg
Price
$96
Updated
2021/12/16
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R788(Fostamatinib disodium) Chemical Properties,Usage,Production

Uses

R 788 Sodium Salt is the sodium salt of R 788 which is a selective spleen tyrosine kinase (Syk) inhibitor. It may be used in the treatment of autoimmune diseases such as type 1 diabetes and has been tested in the treatment of rheumatoid athritis, leukemia and lymphoma.

Biological Activity

r788, which is the prodrug of r406, is a potnet and selective syk inhibitor. the spleen tyrosine kinase (syk) plays a key role in the signaling of activating fc receptors and the b-cell receptor (bcr).

in vitro

r406 was found to induce the apoptosis of the majority of examined dlbcl cell lines and could specifically inhibit both tonic- and ligand-induced bcr signaling (autophosphorylation of syk525/526 and sykdependent phosphorylation of the b-cell linker protein [blnk]) [1].

in vivo

r788 effectively inhibits bcr signaling, demonstrating reduced proliferation and survival of the malignant b cells and significantly prolonged survival of the treated eμ-tcl1 transgenic mouse. moreover, the effect of r788 was found to be selective for the malignant clones, since no disturbance in the production of normal b lymphocytes was observed [2].

target

Syk

References

[1] chen l, monti s, juszczynski p, daley j, chen w, witzig te, habermann tm, kutok jl, shipp ma. syk-dependent tonic b-cell receptor signaling is a rational treatment target in diffuse large b-cell lymphoma. blood. 2008 feb 15;111(4):2230-7.
[2] suljagic m, longo pg, bennardo s, perlas e, leone g, laurenti l, efremov dg. the syk inhibitor fostamatinib disodium (r788) inhibits tumor growth in the eμ- tcl1 transgenic mouse model of cll by blocking antigen-dependent b-cell receptor signaling. blood. 2010 dec 2;116(23):4894-905.
[3] bajpai m. fostamatinib, a syk inhibitor prodrug for the treatment of inflammatory diseases. idrugs. 2009 mar;12(3):174-85.

R788(Fostamatinib disodium) Preparation Products And Raw materials

Raw materials

Preparation Products

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R788(Fostamatinib disodium) Suppliers

Shanghai Boyle Chemical Co., Ltd.
Tel
Fax
86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2922
Advantage
55
Chembest Research Laboratories Limited
Tel
+86-21-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6005
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61
Jinan Trio PharmaTech Co., Ltd.
Tel
+86 (531) 88811783
Fax
+86 (531) 55696010 QQ 1762738062
Email
sales@trio-pharmatech.com (International market)
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China
ProdList
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Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
meilunui@163.com
Country
China
ProdList
4727
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Shanghai civi chemical technology co.,Ltd
Tel
86-21-34053660
Fax
86-21-34053661
Email
sale@labgogo.com
Country
China
ProdList
9865
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Beijing HuaMeiHuLiBiological Chemical
Tel
010-56205725
Fax
010-65763397
Email
waley188@sohu.com
Country
China
ProdList
12335
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NCE Biomedical Co.,Ltd.
Tel
4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988
Fax
+86-27-87599188
Country
China
ProdList
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Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7552
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61
SYN|thesis med chem P/L
Tel
+86-021-50720296
Fax
+86-021-50720297
Email
service@synkinase.com
Country
China
ProdList
266
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Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-400-6206333 18521732826
Fax
021-50323701
Email
market@aladdin-e.com
Country
China
ProdList
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View Lastest Price from R788(Fostamatinib disodium) manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
Fostamatinib disodium 1025687-58-4
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-06-26
Career Henan Chemical Co
Product
R788(Fostamatinib disodium) 1025687-58-4
Price
US $3.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100kg
Release date
2019-08-06

1025687-58-4, R788(Fostamatinib disodium)Related Search:


  • R788(Fostamatinib disodium)
  • R788, Fostamatinib
  • R935788 (FostaMatinib disodiuM)
  • FosD
  • FOSTAMATINIB;FOSD;TAMATINIB FOSDIUM
  • Tamatinib Fosdium
  • R788(prodrug of R406)
  • R935788 (FostaMatinib disodiuM, R788)
  • 6-[[5-Fluoro-2-[(3,4,5-trimethoxyphenyl)amino]-4-pyrimidinyl]amino]-2,2-dimethyl-4-[(phosphonooxy)methyl]-2H-pyrido[3,2-b]-1,4-oxazin-3(4H)-one sodium salt
  • R788; R-935788;R 788 SODIUM;FOSD
  • R788 disodium (Fostamatinib)
  • R788; FOSTAMATINIB;R-788
  • sodium (6-((5-fluoro-2-((3,4,5-trimethoxyphenyl)amino)pyrimidin-4-yl)amino)-2,2-dimethyl-3-oxo-2H-pyrido[3,2-b][1,4]oxazin-4(3H)-yl)methyl phosphate
  • R788 disodium, >=98%
  • R788 disodium
  • R788(prodrug of R46)
  • R788 (sodium salt)
  • Disodium (6-(5-fluoro-2-(3,4,5-trimethoxyphenylamino)pyrimidin-4-ylamino)-2,2-dimethyl-3-oxo-2
  • R 788 sodium
  • R 935788 sodium
  • FostaMatinib sodiuM
  • Fostamatinib/R788 disodium)
  • 2H-Pyrido[3,2-b]-1,4-oxazin-3(4H)-one, 6-[[5-fluoro-2-[(3,4,5-trimethoxyphenyl)amino]-4-pyrimidinyl]amino]-2,2-dimethyl-4-[(phosphonooxy)methyl]-, sodium salt (1:2)
  • 6-[[5-Fluoro-2-[(3,4,5-trimethoxyphenyl)amino]-4-pyrimidinyl]amino]-2,2-dimethyl-4-[(phosphonooxy)methyl]-2H-pyrido[3,2-b]-1,4-oxazin-3(4H)-one sodium salt R788 (Fostamatinib) Disodium R 935788 sodium
  • Fostamatinib disodium R 788 sodium
  • R788(Fostamatinib disodium) USP/EP/BP
  • R 788 Sodium Salt DISCONTINUED. Please see R070115.
  • Fostamatinib Disodium (R788
  • Fo(R788) disodium
  • prodrug of R-406
  • 1025687-58-4
  • C23H24FN6Na2O9P
  • C23H24FN6O9P2Na
  • Inhibitors