1-O-9Z-Octadecenoyl-sn-glyceryl-3-phosphoricacidsodiumsalt

Product Name: 1-O-9Z-Octadecenoyl-sn-glyceryl-3-phosphoricacidsodiumsalt
CAS No.: 325465-93-8
Chemical Name: 1-O-9Z-Octadecenoyl-sn-glyceryl-3-phosphoricacidsodiumsalt
Synonyms: 18:1 LPA;18:1 Lyso PA;PA(18:1(9Z)/0:0);1-Oleoyl lysophospha;Lysophosphatidic Acid;Lysophosphatidic acid (LPA);Lysophosphatidic acid (Oleyl form);1-Oleoyl lysophosphatidic acid (sodium);Sodium (R,Z)-2-hydroxy-3-(oleoyloxy)propyl hydrogenphosphate;1-Oleoyl-2-hydroxy-sn-glycerol-3-phospholipid acid (sodium salt) (18:1 LYSO PA
CBNumber: CB32518878
Molecular Formula: C21H40NaO7P
Formula Weight: 458.501631
MOL File: 325465-93-8.mol

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1-O-9Z-Octadecenoyl-sn-glyceryl-3-phosphoricacidsodiumsalt Property

storage temp.: Inert atmosphere,Store in freezer, under -20°C
solubility: Soluble in DMSO (up to 1 mg/ml with warming) or in Water (up to 10 mg/ml with warming).
form: Waxy solid.
color: White
Water Solubility: Soluble in water up to 5mg/ml with sonication
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 1 month.

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 62215
Product name: 1-Oleoyl Lysophosphatidic Acid (sodium salt)
Purity: ≥95%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 62215
Product name: 1-Oleoyl Lysophosphatidic Acid (sodium salt)
Purity: ≥95%
Packaging: 5mg
Price: $78
Updated: 2024/03/01

Cayman Chemical

Product number: 62215
Product name: 1-Oleoyl Lysophosphatidic Acid (sodium salt)
Purity: ≥95%
Packaging: 10mg
Price: $139
Updated: 2024/03/01

Cayman Chemical

Product number: 62215
Product name: 1-Oleoyl Lysophosphatidic Acid (sodium salt)
Purity: ≥95%
Packaging: 50mg
Price: $533
Updated: 2024/03/01

American Custom Chemicals Corporation

Product number: LIP0002816
Product name: 1-OLEOYL-2-HYDROXY-SN-GLYCERO-3-PHOSPHATE SODIUM SALT
Purity: 95.00%
Packaging: 5MG
Price: $501.96
Updated: 2021/12/16

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1-O-9Z-Octadecenoyl-sn-glyceryl-3-phosphoricacidsodiumsalt Chemical Properties,Usage,Production

Description

Lysophosphatidic acid (325465-93-8) is a multifunctional intercellular bioactive phospholipid.1?Stimulates the growth of a variety of cells including fibroblasts, vascular smooth muscle cells, endothelial cells and keratinocytes among others.1?Acts as a proliferative and anti-apoptotic factor.2?Lysophophatidic acid is an agonist at LPA1?(EDG-2), LPA2?(EDG-4) and LPA3?(EDG-7) receptors.3?LPA-primed astrocytes induce axonal outgrowth of cortical progenitors.4

Uses

It is an endogenous agonist for LPA1?and LPA2?receptors. LPA does not induce angiogenesis, but has effects on endothelial cell physiology that are similar to those of sphingosine 1-phosphate. Induces cell migration of cancer and non-cancer cells. LPA has also been described to potentiate acetylchloine receptor currents by G-protein-mediated activation of Ca2+-dependent/independent protein kinase C.

in vitro

lpa could mediate signal transduction via edg/lpa receptor, inducing the proliferation, migration, adhesion and antiapoptotic function of tumor cells. additionally, lpa was found to elicit upregulation of vegf, leading to an indirect influence on initiation and progression of malignancies. lpa could also stimulate matrix metalloproteinase secretion and tumor angiogenesis factor [1].

in vivo

lpa was tested for its vascular remodeling effect in a rat model of hypoxic pulmonary hypertension. serum from animals in the hypoxic group showed higher chemoattractant properties toward rat primary lung fibroblasts, and such cell migration increase was prevented by the lpa receptor 1 and 3 antagonists. lpa also found to increase adhesive properties of human pulmonary artery endothelial cells, via the activation of lpa receptor 1 or 3 [1].

storage

-20°C

References

[1] MOOLENAAR W H. Lysophosphatidic acid, a multifunctional phospholipid messenger.[J]. The Journal of Biological Chemistry, 1995, 270 22: 12949-12952. DOI:10.1074/jbc.270.22.12949
[2] J S LEVINE. Lysophosphatidic acid: a novel growth and survival factor for renal proximal tubular cells.[J]. American Journal of Physiology, 1997, 273 4: F575-85. DOI:10.1152/ajprenal.1997.273.4.f575
[3] EDWARD J. GOETZL Songzhu A. Diversity of cellular receptors and functions for the lysophospholipid growth factors lysophosphatidic acid and sphingosine 1-phosphate[J]. FASEB Journal, 1998, 12 15: 1589-1598. DOI:10.1096/fasebj.12.15.1589
[4] TANIA CRISTINA LEITE DE SAMPAIO E SPOHR. LPA-primed astrocytes induce axonal outgrowth of cortical progenitors by activating PKA signaling pathways and modulating extracellular matrix proteins.[J]. Frontiers in Cellular Neuroscience, 2014: 296. DOI:10.3389/fncel.2014.00296

1-O-9Z-Octadecenoyl-sn-glyceryl-3-phosphoricacidsodiumsalt Preparation Products And Raw materials

Raw materials

Preparation Products

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1-O-9Z-Octadecenoyl-sn-glyceryl-3-phosphoricacidsodiumsalt Suppliers

China 53 United Kingdom 1 United States 8 USA 1 Global 63

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325465-93-8, 1-O-9Z-Octadecenoyl-sn-glyceryl-3-phosphoricacidsodiumsaltRelated Search:

1,6-BIS(CYCLOHEXYLOXIMINOCARBONYLAMINO)HEXANE MK-886 Phytosphingosine Palmitoylethanolamide Dodecyl dihydrogen phosphate L-NASPA (R)-2-(4'-(4-(((1-(2-chlorophenyl)ethoxy)carbonyl)aMino)-3-Methylisoxazol-5-yl)-[1,1'-biphenyl]-4-yl)acetic acid BMS-986278 TC LPA5 4 BMS-986020

Lysophosphatidic acid (LPA)

Lysophosphatidic Acid

18:1 LPA

18:1 Lyso PA

1-OLEOYL-2-HYDROXY-SN-GLYCERO-3-PHOSPHATE (SODIUM SALT);18:1 LYSO PA;PA(18:1(9Z)/0:0);18:1 LPA;O-LPA

PA(18:1(9Z)/0:0)

Sodium (R,Z)-2-hydroxy-3-(oleoyloxy)propyl hydrogenphosphate

1-Oleoyl lysophospha

1-Oleoyl lysophosphatidic acid (sodium)

Lysophosphatidic acid (Oleyl form)

inhibit,mitosis,anxiety,LPL Receptor,depression,LPA,1Oleoyl lysophosphatidic acid sodium,1 Oleoyl lysophosphatidic acid sodium,Inhibitor,Lysophospholipid Receptor,1-Oleoyl lysophosphatidic acid,DNA

1-Oleoyl-2-hydroxy-sn-glycerol-3-phospholipid acid (sodium salt) (18:1 LYSO PA

325465-93-8

C21H40NaO7P