ChemicalBook > CAS DataBase List > 4-[1-Cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-2-pyrimidinaminedihydrochloride

4-[1-Cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-2-pyrimidinaminedihydrochloride

Product Name
4-[1-Cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-2-pyrimidinaminedihydrochloride
CAS No.
950912-80-8
Chemical Name
4-[1-Cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-2-pyrimidinaminedihydrochloride
Synonyms
CS-318;PF 67046;PF 670462;PF-670462 HCL;PF-670462 2HCl;PF 670462, >=98%;PF670462/ PF-670462;PF670462 dihydrochloride;PF-670462 (hydrochloride);Casein Kinase I Inhibitor II, PF-670462
CBNumber
CB32518984
Molecular Formula
C19H20FN5.2HCl
Formula Weight
410
MOL File
950912-80-8.mol
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4-[1-Cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-2-pyrimidinaminedihydrochloride Property

Melting point:
>178°C (dec.)
storage temp. 
2-8°C
solubility 
H2O: soluble2mg/mL, clear (warmed)
form 
powder
color 
white to beige
InChIKey
PSNKGVAXBSAHCH-UHFFFAOYSA-N
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0795
Product name
PF-670462
Purity
≥98% (HPLC)
Packaging
5mg
Price
$132
Updated
2024/03/01
Cayman Chemical
Product number
14588
Product name
PF-670462 (hydrochloride)
Purity
≥99%
Packaging
10mg
Price
$166
Updated
2024/03/01
Cayman Chemical
Product number
14588
Product name
PF-670462 (hydrochloride)
Purity
≥99%
Packaging
50mg
Price
$576
Updated
2024/03/01
Sigma-Aldrich
Product number
SML0795
Product name
PF-670462
Purity
≥98% (HPLC)
Packaging
25mg
Price
$537
Updated
2024/03/01
Tocris
Product number
3316
Product name
PF670462
Purity
≥99%(HPLC)
Packaging
50
Price
$980
Updated
2021/12/16
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4-[1-Cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-2-pyrimidinaminedihydrochloride Chemical Properties,Usage,Production

Description

The casein kinase 1 (CK1) family of kinases regulate diverse processes, particularly related to circadian rhythms and sensitivity to amphetamines. PF-670462 is a potent inhibitor of the CK1 isoforms CK1ε and CK1δ (IC50 = 7.7 and 14 nM, respectively). It less effectively inhibits a wide variety of related or common kinases. Through its effects on CK1, PF-670462 disrupts circadian rhythms in cells and animals. It also blocks the locomotor response to amphetamines in mice.

Uses

PF 670462 is a potent and selective casein kinase 1ε (CK1ε) and CK1δ inhibitor. PF 670462 has been shown to inhibit PER protein nuclear translocation causing phase shifts in circadian rhythms. PF 670462 attenuates methamphetamine-stimulated locomotion in vivo.

Definition

ChEBI: A hydrochloride salt resulting from the formal reaction of 3-[(3-chlorophenoxy)methyl]-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine with 2 mol eq. of hydrogen chloride. It is a selectiv inhibitor of the delta- and epsilon-isoforms of casein kinase 1 (CK1delta and CK1epsilon).

Biochem/physiol Actions

PF-670462 is also termed as 4-[1-cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-2-pyrimidinamine dihydrochloride). It participates in ceramide transfer between Golgi and ER (endoplasmic reticulum) compartments. PF-670462 affects actin filament consolidation. It also hinders the stability at the front edge of cells treated with N-formyl Met-Leu-Phe.

storage

room temperature (desiccate)

4-[1-Cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-2-pyrimidinaminedihydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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4-[1-Cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-2-pyrimidinaminedihydrochloride Suppliers

Canada 1 China 75 India 2 United Kingdom 2 United States 18 Global 98
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View Lastest Price from 4-[1-Cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-2-pyrimidinaminedihydrochloride manufacturers

Career Henan Chemical Co
Product
4-[1-Cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-2-pyrimidinaminedihydrochloride 950912-80-8
Price
US $1.00/KG
Min. Order
100KG
Purity
99.0%
Supply Ability
1000kg
Release date
2020-03-11

950912-80-8, 4-[1-Cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-2-pyrimidinaminedihydrochlorideRelated Search:

2-FLUOROPHENYL CYCLOPENTYL KETONE TRIS(PENTAFLUOROPHENYL)BORANE

  • PF670462/ PF-670462
  • 4-[1-Cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-2-pyrimidinamine hydrochloride
  • 2-PyriMidinaMine, 4-[1-cyclohexyl-4-(4-fluorophenyl)-1H-iMidazol-5-yl]-, hydrochloride (1:2)
  • PF 67046
  • 4-[1-Cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-2-pyrimidinamine hydrochloride PF670462
  • 4-[3-Cyclohexyl-5-(4-fluoro-phenyl)-3H-imidazol-4-yl]-pyrimidin-2-ylamine dihydrochloride
  • PF 670462, >=98%
  • PF 670462
  • PF-670462 2HCl
  • PF-670462 (hydrochloride)
  • Casein Kinase I Inhibitor II, PF-670462
  • 4-[1-Cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-2-pyrimidinaminedihydrochloride
  • 4-[3-cyclohexyl-5-(4-fluorophenyl)imidazol-4-yl]pyrimidin-2-amine:dihydrochloride
  • Casein Kinase I Inhibitor II, PF-670462 - CAS 950912-80-8 - Calbiochem
  • 4-[1-cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]pyrimidin-2-amine dihydrochloride
  • CS-318
  • PF670462 dihydrochloride
  • PF-670462 HCL
  • 950912-80-8
  • C19H20FN52ClH
  • C19H20FN52HCl
  • C19H22Cl2FN5
  • Inhibitors
  • Aromatics
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Protein Kinase Inhibitors and Activators