ChemicalBook > CAS DataBase List > 3-Hydroxyphthalic anhydride

3-Hydroxyphthalic anhydride

Product Name: 3-Hydroxyphthalic anhydride
CAS No.: 37418-88-5
Chemical Name: 3-Hydroxyphthalic anhydride
Synonyms: 4-HYDROXY-ISOBENZOFURAN-1,3-DIONE;Nsc 80858;Brn 0135783;3-HydroxyphthaL;3-hydroxy-phthalicanhydrid;3-hydroxyphtalic anhydride;3-HYDROXYPHTHALIC ANHYDRIDE;Phthalic anhydride, 3-hydroxy-;4-hydroxy-3-isobenzofurandione;3-HYDROXYPHTHALIC ACID ANHYDRIDE
CBNumber: CB3253702
Molecular Formula: C8H4O4
Formula Weight: 164.12
MOL File: 37418-88-5.mol

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3-Hydroxyphthalic anhydride Property

Melting point:: 199-202 °C (lit.)
Boiling point:: 365.4±25.0 °C(Predicted)
Density: 1.624±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
solubility: Acetonitrile (Slightly), DMSO (Slightly)
pka: 6.25±0.20(Predicted)
form: Powder
color: White to beige
BRN: 135783
Stability:: Hygroscopic
InChI: InChI=1S/C8H4O4/c9-5-3-1-2-4-6(5)8(11)12-7(4)10/h1-3,9H
InChIKey: CCTOEAMRIIXGDJ-UHFFFAOYSA-N
SMILES: C1(=O)C2=C(C(O)=CC=C2)C(=O)O1
CAS DataBase Reference: 37418-88-5(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
RTECS: TI3300000
F: 21
HS Code: 29182900
Toxicity: mouse,LD50,intravenous,75mg/kg (75mg/kg),U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#08845,

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 308021
Product name: 3-Hydroxyphthalic anhydride
Purity: 98%
Packaging: 1g
Price: $296.4
Updated: 2025/07/31

TCI Chemical

Product number: H1799
Product name: 4-Hydroxyisobenzofuran-1,3-dione
Purity: min. 98.0 %
Packaging: 1G
Price: $73
Updated: 2025/07/31

TCI Chemical

Product number: H1799
Product name: 4-Hydroxyisobenzofuran-1,3-dione
Purity: min. 98.0 %
Packaging: 5G
Price: $219
Updated: 2025/07/31

TRC

Product number: H951270
Product name: 3-Hydroxyphthalic anhydride
Packaging: 2.5g
Price: $60
Updated: 2021/12/16

Oakwood

Product number: 222694
Product name: 4-Hydroxyisobenzofuran-1,3-dione
Packaging: 250mg
Price: $20
Updated: 2021/12/16

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3-Hydroxyphthalic anhydride Chemical Properties,Usage,Production

Description

3-Hydroxyphthalic anhydride: a valuable raw material for chemical industry and pharmaceutical research.
Phthalic anhydride derivatives have been applied as plasticizers and heat-resistant polymers in the chemical industry. One of its derivatives is the 3-hydroxyphthalic anhydride (3-HPA), which exhibits a hydroxyl group substituent in position 3. 3-Hydroxyphthalic anhydride can be used as raw material for heat-resistant resins such as epoxy resins, polyesters, polyimides, etc., or as raw material for physiologically active substances such as medicines and pesticides. It has been shown that 3-HPA can serve as a raw material to obtain drugs with potential applications, such as anticancer, antimicrobial and in treating diabetes, herpes, and HIV[1].

Chemical Properties

Beige powder

Uses

3-Hydroxyphthalic Anhydride is used to synthesize 3-Hydroxyphthalic Anhydride-modified human serum albumin whichhas high potency as a microbicide for prevention of the sexual transmission of HIV. It is also used as a reagent in organicsynthesis of other compounds including that of inhibitors of NF-κB derived from thalidomide.

Synthesis Reference(s)

Journal of the American Chemical Society, 77, p. 5092, 1955 DOI: 10.1021/ja01624a042
Synthesis, p. 788, 1985 DOI: 10.1055/s-1985-31350

Synthesis

In the presence of triethylamine, the 2-oxo-2, 5-dihydrofuran, and pivaloyl chloride reactions generate 2-valeryl oxo furans. The affixture with 2-valeryl oxo furans and maleic anhydride uses vitriolization, which thereby generates the method of 3-hydroxyl phthalic anhydride.

References

[1] M. López-Ortega. “Standard enthalpies of formation of 3-hydroxyphthalic anhydride.” Revista Mexicana De Fisica (2022).

3-Hydroxyphthalic anhydride Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 3-Hydroxyphthalic anhydride manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: 3-HYDROXYPHTHALIC ANHYDRIDE 37418-88-5
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100 mt
Release date: 2024-11-19

Asia Chem I and E (Jiangsu) Co Ltd

Product: 3-Hydroxyphthalic anhydride 37418-88-5
Price: US $125.58/Kg/Drum
Min. Order: 25Kg/Drum
Purity: 98.00%HPLC
Supply Ability: 1ton/month
Release date: 2021-09-17

Suzhou Nordica Biopharma CO.,LTD

Product: 3-Hydroxyphthalic anhydride 37418-88-5
Price: US $0.00-0.00/kg
Min. Order: 0.01kg
Purity: 0.98
Supply Ability: 2 tons
Release date: 2024-11-15

37418-88-5, 3-Hydroxyphthalic anhydrideRelated Search:

3-AMINOPHTHALIC ACID HYDROCHLORIDE 3-IODOPHTHALIC ACID 1-Methyl-3-nitrophthalate 3-Oxocyclopentanecarboxylic acid 4-Hydroxyphthalic acid 3-AMINOPHTHALIC ACID 3-BOC-AMINO-2,6-DIOXOPIPERIDINE Luminol 3-HYDROXYPHTHALIC ANHYDRIDE 4-HYDROXYPHTHALIC ANHYDRIDE 3,6-DIACETOXYPHTHALIC ACID ANHYDRIDE AKOS 200-04 AKOS 220-67 AKOS 237-82 4,7-DIHYDROXY-2-BENZOFURAN-1,3-DIONE AKOS 215-94 AKOS 243-37 AKOS 212-66

4-HYDROXY-ISOBENZOFURAN-1,3-DIONE

3-HYDROXYPHTHALIC ACID ANHYDRIDE

3-HYDROXYPHTHALIC ANHYDRIDE

3-hydroxy-phthalicanhydrid

4-hydroxy-3-isobenzofurandione

1,3-Isobenzofurandione, 4-hydroxy-

Brn 0135783

Nsc 80858

Phthalic anhydride, 3-hydroxy-

4-hydroxy-1,3-dihydro-2-benzofuran-1,3-dione

4-Hydroxy-2-benzofuran-1,3-dione

3-HYDROXYPHTHALIC ANHYDRIDE 97+%

4-Hydroxy-1,3-isobenzofurandione

3-HydroxyphthaL

3-hydroxyphtalic anhydride

3-HYDROXYPHTHALIC ANHYDRIDE ISO 9001：2015 REACH

3-Hydroxyphthalic anhydride 4-Chlorophthalic anhydride

3-hydroxy-phthalicanhydrid, 10 mM in DMSO

4-hydroxyisobenzofuran-1,3-dione 98%

37418-88-5

Organic Building Blocks

Carbonyl Compounds

Carboxylic Acid Anhydrides

Building Blocks

Anhydride Monomers

Monomers

Polymer Science

Carbonyl Compounds

Carboxylic Acid Anhydrides

Organic Building Blocks

Phthalic Acids, Esters and Derivatives

37418-88-5