ChemicalBook > CAS DataBase List > Dutasteride

Dutasteride

Product Name
Dutasteride
CAS No.
164656-23-9
Chemical Name
Dutasteride
Synonyms
Avodart;Avolve;Duagen;(5α,17β)-;GI 198745;utasteride;DUTASTERIDE;Dutarantine;Dutasteride API;Dutasteride CRS
CBNumber
CB3254628
Molecular Formula
C27H30F6N2O2
Formula Weight
528.53
MOL File
164656-23-9.mol
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Dutasteride Property

Melting point:
242-250°C
Boiling point:
620.3±55.0 °C(Predicted)
Density 
1.303±0.06 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
DMSO: soluble2mg/mL, clear
pka
13.32±0.70(Predicted)
form 
powder
color 
white to beige
optical activity
[α]/D +18 to +24°, c = 1 in chloroform-d
BCS Class
2/4
InChIKey
JWJOTENAMICLJG-QWBYCMEYSA-N
SMILES
N1[C@@]2([H])[C@@](C)([C@@]3([H])CC[C@@]4(C)[C@]([H])([C@]3([H])CC2)CC[C@@H]4C(NC2=CC(C(F)(F)F)=CC=C2C(F)(F)F)=O)C=CC1=O
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Safety

HS Code 
2937290000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H351Suspected of causing cancer

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML1221
Product name
Dutasteride
Purity
≥98% (HPLC)
Packaging
10mg
Price
$100
Updated
2024/03/01
Sigma-Aldrich
Product number
1229922
Product name
Dutasteride
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
200mg
Price
$607
Updated
2024/03/01
Cayman Chemical
Product number
15956
Product name
Dutasteride
Purity
≥98%
Packaging
5mg
Price
$68
Updated
2024/03/01
Cayman Chemical
Product number
15956
Product name
Dutasteride
Purity
≥98%
Packaging
10mg
Price
$130
Updated
2024/03/01
Sigma-Aldrich
Product number
Y0001603
Product name
Dutasteride for system suitability
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
y0001603
Price
$152
Updated
2024/03/01
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Dutasteride Chemical Properties,Usage,Production

Description

Dutasteride is a synthetic 4-azasteroid compound. It is a dual inhibitor of type 1 and 2 isoforms of 5α-reductase unlike finasteride, the first marketed 5α-reductase inhibitor, which only acts on type 2 isozyme. Dutasteride is a 3-fold greater inhibitor of type-2 5α-reductase than finasteride in men and has greater effect on the type-l than on type-2 isozyme. In animal models,dutasteride exhibited superior efficacy and pharmacokinetics compared to finasteride. In patients with benign prostate hyperplasia, administration of dutasteride was shown to dose-dependently decrease serum dihydrotestosterone levels with greater efficacy as compared to finasteride (95% vs 67%). Serum testosterone levels increased with both active drugs, in conjunction with dihydrotestosterone suppression but remained within normal ranges. In long term studies, in men with moderate to severe benign prostate hyperplasia, once daily dutasteride significantly reduced prostate volume, reduced the risk of acute urinary retention and surgery by 57% and improved lower urinary tract symptoms and urinary flow measurements.

Chemical Properties

Dutasteride is a white to pale yellow powder It is soluble in ethanol (44 mg/mL), methanol (64 mg/mL), and polyethylene glycol 400 (3 mg/mL), but it is insoluble in water.

Originator

GlaxoSmithKline (UK)

Uses

Dutasteride is a dual inhibitor of 5a-reductase isoenzymes type 1 and 2; structurally related to Finasteride. Dutasteride is used in the treatment of benign prostatic hyperplasia. Dutasteride is associated with a low rate of transient serum aminotransferase elevations, but has yet to be linked to instances of clinically apparent acute liver injury.

Definition

ChEBI: Dutasteride is an aza-steroid that is inasteride in which the tert-butyl group is replaced by a 2,5-bis(trifluoromethyl)phenyl group. A synthetic 4-azasteroid, dutasteride is a selective inhibitor of both the type 1 and type 2 isoforms of steroid 5alpha-reductase, an intracellular enzyme that converts testosterone to 5alpha-dihydrotestosterone. Dutasteride is used for the treatment of symptomatic benign prostatic hyperplasia in men with an enlarged prostate gland. It has a role as an EC 1.3.1.22 [3-oxo-5alpha-steroid 4-dehydrogenase (NADP(+))] inhibitor and an antihyperplasia drug. It is an aza-steroid, a member of (trifluoromethyl)benzenes and a delta-lactam. It derives from a hydride of a 5alpha-androstane.

brand name

Avodart (GlaxoSmithKline).

Biological Functions

Similar to finasteride, dutasteride is a competitive and mechanism-based inhibitor not only of type 2 but also of type 1 5α-reductase isoenzymes, with which stable enzyme-NADP adduct complexes are formed, inhibiting the conversion of testosterone to DHT. The suppression of both type 1 and type 2 isoforms results in greater and more consistent reduction of plasma DHT than that observed for finasteride. The more effective dual inhibition of type 1 and type 2 5α-reductase isoforms lowers circulating DHT to a greater extent than with finasteride and shows advantages in treating BPH and other disease states (e.g., prostate cancer) that are DHT-dependent.

Biochem/physiol Actions

Dutasteride is a potent dual inhibitor of 5α-reductase isoenzymes types 1 and 2 (IC50 = 6 nM 5-AR1; 7 nM 5-AR2). Dutasteride blocks testosterone conversion to dihydrotesterone, and is used clinically for treating benign prostatic hyperplasia (BPH).

Pharmacokinetics

The maximum effect of 0.5 mg daily doses of dutasteride on the suppression of DHT is dose-dependent and is observed within 1 to 2 weeks. After 2 weeks of 0.5 mg daily dosing, median plasma DHT concentrations were reduced by 90%, and after 1 year, the median decrease in plasma DHT was 94%. The median increase in plasma testosterone was 19% but remained within the physiological range. The drug also reduced serum prostatic specific antigen by approximately 50% at 6 months and total prostate volume by 25% at 2 years. Dutasteride produced improvements in quality of life and peak urinary flow rate and reduction of acute urinary retention without the need for surgery.

Clinical Use

Dutasteride belongs to azasteriod class of compounds and function as a 5α-reductase inhibitor1 which prevents the conversion of the androgen sex hormone testosterone into the more potent metabolite dihydrotestosterone (DHT). In 2009, South Korea has been licensed dutasteride for the treatment of androgenetic alopecia and in Japan 2015.
Dutasteride is the first and only double 5α reductase inhibitor used to treat Benign prostatic hyperplasia, and it is mainly used clinically to treat prostate enlargement, male-pattern hair loss, seborrheic hair loss, and hereditary hair loss.

Side effects

The main side effects are ED, decreased libido, gynecomastia, and ejaculation disorders. Long-term use (>4 years), however, did not reveal increased onset of sexual side effects. In addition, the combination of dutasteride and tamsulosin is well-tolerated and has the added advantage of rapid symptomatic relief.

Synthesis

Dutasteride can be prepared from 3-oxo-4-androstene-17β-carboxylic acid by several ways in 6 or 8 steps. In the preparation of dutasteride, the introduction of the carbon-carbon double bond in conjugation with C-3 carbonyl carbon of azaandrosteriods is one of the most important chemical reaction.
an efficient synthesis of dutasteride: utilizing benzoyl group as novel lactamic protecting group

in vivo

dutasteride, which inhibits both 5αr1/5αr2, is efficacious in blocking prostate cancer development or progression in c57bl/6 tramp x fvb mice [2].

Metabolism

Dutasteride is metabolised by the cytochrome P450 isoenzymes CYP3A4 and CYP3A5, and most of a dose is excreted as metabolites in the faeces.

Mode of action

The human body contains type I and type II 5α reductase, with type II found mainly in the prostate, and type I found mainly in the liver and skin. 5α reductase is the main cause for continuous benign prostate enlargement; it promotes the transformation of testosterone in patients’ prostate into the more active dihydrotestosterone, thus causing prostate cells to enlarge and the prostate to swell. Dutasteride can inhibit both type I and II 5α reductase at the same time. This type of simultaneous inhibiting mechanism can rapidly and continuously reduce prostate size, dramatically improve urination, and reduce the risk fo acute urinary retention and its related prostate surgeries.

Clinical claims and research

The American FDA approved a 2-year multicenter randomized double-blind control clinical trial – the first long term clinical assessment of the combined usage of Dutasteride and α receptor blockers. Included subjects were male patients with moderate to severe prostate enlargement (ages greater than or equal to 50, prostate volume (PV) ≥30 cc, serum prostate specific antigen (PSA) levels 1.5-10ng/ml, 5ml/sec < maximum urinary flow (Qmax) ≤15ml/sec, minimum urination ≥ 125ml, international prostate symptom score (IPSS) ≥ 12). Patients were first given a placebo for 4 weeks and then were randomly given either 0.5mg/day of Dutasteride and 0.4mg/day of Tamsulosin, only 0.5mg/day of Dutasteride, or only 0.4mg/day of Tamsulosin.
Results showed: After 12-24 months, the combined usage of Dutasteride with Tamsulosin had better curative effects than did individual usage.

References

[1] schmidt lj1, murillo h, tindall dj. gene expression in prostate cancer cells treated with the dual 5 alpha-reductase inhibitor dutasteride. j androl. 2004 nov-dec;25(6):944-53.
[2] opoku-acheampong ab1, unis d, henningson jn, beck ap, lindshield bl.preventive and therapeutic efficacy of finasteride and dutasteride in tramp mice. plos one. 2013 oct 18;8(10):e77738. doi: 10.1371/journal.pone.0077738. ecollection 2013.

Dutasteride Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Dutasteride manufacturers

Hebei Mojin Biotechnology Co.,Ltd
Product
Dutasteride 164656-23-9
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
50000KG/month
Release date
2024-07-24
Hebei Jiafan Trading Company Limited
Product
Dutasteride 164656-23-9
Price
US $5.00/Box
Min. Order
1Box
Purity
99.99%
Supply Ability
20000 boxes
Release date
2025-01-10
Hebei Zhuanglai Chemical Trading Co Ltd
Product
Dutasteride 164656-23-9
Price
US $150.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
500kg
Release date
2024-12-02

164656-23-9, DutasterideRelated Search:

2,5-Bis(trifluoromethyl)aniline 1,4-Bis(trifluoromethyl)-benzene Diphenyl ether Finasteride PHENYL VALERATE PHENYL RESIN METHYL 4-AZA-5ALPHA-ANDROSTA-1-EN-3-ONE-17BETA-CARBOXYLATE Dihydrodutasteride 5β-Dutasteride (5a,6a,17)-N-(1,1-Dimethylethyl)-6-hydroxy-3-oxo-4-azaandrost-1-ene-17-carboxamide 2,6-BIS(TRIFLUOROMETHYL)ANILINE 4-Aza-5a-androstan-1-ene-3-one-17b-carboxylic acid 3,4-Bis-trifluoromethyl-phenylamine Dutasteride EP Impurity I Dutasteride Related Impurity 1 Ethyl 3-Oxo-4-aza-5α-androst-1-ene-17β-carboxylate JWJOTENAMICLJG-XHGXNVPLSA-N 5,6-Dehydro-17β-dutasteride

  • (1S,2R,7R,10S,11S,14S,15S)-N-[2,5-bis(trifluoroMethyl)phenyl]-2,15-diMethyl-5-oxo-6-azatetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-3-ene-14-carboxaMide
  • (4aR,4bS,6aS,7S,9aS,9bS,11aR)-N-[2,5-Bis(trifluoroMethyl)phenyl]-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-4a,6a-diMethyl-2-oxo-1H-Indeno[5,4-f]quinoline-7-carboxaMide
  • (5α,17β)-
  • (4aR,4bS,6aS,7S,9aS,9bS,11aR)-N-[2,5-Bis(trifluoroMethyl)phenyl]-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-4a,6a-diMethyl-2-oxo-1H-indeno[5,4-f]quinoline-7-carboxaMide-13C6
  • 6β-Hydroxy Dutasteride
  • 4-Azaandrost-1-ene-17-carboxaMide, N-[2,5-bis(trifluoroMethyl)phenyl]-3-oxo-, (5a,17b)-
  • Avolve
  • 5,6-Dehydro-17&alpha
  • Dutasteride API
  • (4aR,4bS,6aS,7S,9aS,9bS,11aR)-N-(2,5-Bis(trifluoroMethyl)phenyl)-4a,6a-diMethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-indeno[5,4-f]quinoline-7-carboxaMide
  • Dutasteride for system suitability
  • Dutasteride (200 mg)
  • Duagen
  • (5a,17)-N-[2,5-Bis(trifluoromethyl)phenyl]-3-oxo-4-azaandrost-1-ene-17-carboxamide
  • Avodart
  • GI 198745
  • GG-745, GI-198745,
  • 5α,17β)-N-[2,5-Bis(trifluoromethyl)phenyl]-3-oxo-4- Aza -androst-1-ene-17-carboxamide
  • (5alpha,17beta)-n-{2,5-bis(trifluoromethyl)phenyl}-3-oxo-4-azaandrost-l-ene-17-carboxamide
  • DUTASTERIDE
  • Dutasteride(Avodart)
  • Dutasteride (GG-745)
  • 5,6-Dehydro-17&beta
  • Dutasteride CRS
  • Dutasteride for system suitability CRS
  • 1H-Indeno[5,4-f]quinoline-7-carboxamide, N-[2,5-bis(trifluoromethyl)phenyl]-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-4a,6a-dimethyl-2-oxo-, (4aR,4bS,6aS,7S,9aS,9bS,11aR)-
  • Dutasteride USP/EP/BP
  • Dutasteride (1.0mg/ml in DMSO)
  • Avodart , Dutasteride
  • Anti-Hairloss CAS 164656-23-9 99% Powder Ru58841 Finasteride Dutasteride
  • Dutasteride (Y0001598)
  • Dutasteride for system suitability (Y0001603)
  • Dutasteride (1229922)
  • Oral Dutasteride Avodart
  • utasteride
  • Dutasteride CAS 164656-23-9
  • Dutarantine
  • DUTASTERIDE 0.25% , 0.5% PELLETS
  • 1,(5α)-ANDROSTEN-4-AZA-3-ONE-17β- N - [2,5-BIS (TRIFLUOROMETHYL0 PHENYL] - CARBOXAMIDE
  • Dutasteride in Methanol
  • Dutasteride, dual 5alpha reductase type 1 and type 2 inhibitor
  • Dutasteride, 10 mM in DMSO
  • 164656-23-9
  • 64656-23-9
  • C27H30F6N2O2
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