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TCS 21311

Product Name
TCS 21311
CAS No.
1260181-14-3
Chemical Name
TCS 21311
Synonyms
NIBR-3049;TCS 21311;TCS21311; TCS-21311;JAK3/GSK-3β/PKCα Inhibitor;JAK3/GSK-3β/PKCα Inhibitor - CAS 1260181-14-3 - Calbiochem;3-{5-[4-(2-hydroxy-2-methylpropionyl)piperazin-1-yl]-2-trifluoromethylphenyl}-4-(1H-indol-3-yl)pyrrole-2,5-dione;3-(5-(4-(2-Hydroxy-2-methylpropanoyl)piperazin-1-yl)-2-(trifluoromethyl)phenyl)-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione;3-[5-[4-(2-Hydroxy-2-Methyl-1-oxopropyl)-1-piperazinyl]-2-(trifluoroMethyl)phenyl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione;1H-Pyrrole-2,5-dione, 3-[5-[4-(2-hydroxy-2-methyl-1-oxopropyl)-1-piperazinyl]-2-(trifluoromethyl)phenyl]-4-(1H-indol-3-yl)-;Protein kinase C,TCS 21311,Glycogen synthase kinase 3,NIBR 3049,TCS21311,GSK-3,Glycogen synthase kinase-3,Inhibitor,JAK,inhibit,NIBR-3049,TCS-21311,Janus kinase,PKC
CBNumber
CB32546792
Molecular Formula
C27H25F3N4O4
Formula Weight
526.51
MOL File
1260181-14-3.mol
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TCS 21311 Property

Boiling point:
793.0±60.0 °C(Predicted)
Density 
1.436±0.06 g/cm3(Predicted)
storage temp. 
+2C to +8C
solubility 
<52.65mg/ml in DMSO
form 
Yellow solid
pka
7.91±0.60(Predicted)
color 
White to yellow
InChIKey
CLGRAWDGLMENOD-UHFFFAOYSA-N
SMILES
O=C1NC(C(C2=CNC3=C2C=CC=C3)=C1C4=CC(N5CCN(C(C(C)(C)O)=O)CC5)=CC=C4C(F)(F)F)=O
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Safety

WGK Germany 
WGK 3
Storage Class
11 - Combustible Solids
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
420148
Product name
JAK3/GSK-3β/PKCα Inhibitor - CAS 1260181-14-3 - Calbiochem
Packaging
5mg
Price
$265
Updated
2025/07/31
Tocris
Product number
4221
Product name
TCS21311
Purity
≥98%(HPLC)
Packaging
10
Price
$271
Updated
2021/12/16
Tocris
Product number
4221
Product name
TCS21311
Purity
≥98%(HPLC)
Packaging
50
Price
$1088
Updated
2021/12/16
TRC
Product number
T012650
Product name
TCS-21311
Packaging
10mg
Price
$160
Updated
2021/12/16
Usbiological
Product number
021302
Product name
TCS-21311
Packaging
10mg
Price
$460
Updated
2021/12/16
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TCS 21311 Chemical Properties,Usage,Production

Uses

A potent JAK3 inhibitor; selective for JAK3 over JAK1, JAK2 and TYK2. It also inhibits GSK-3β, PKCα and PKCθ.

Biological Activity

tcs 21311 is a potent and selective jak3 inhibitor with the ic50 values of 8 nm. tcs 21311 shows high selectivity for jak3 over jak1, jak2 and tyk2. the ic50 values are 1017, 2550 and 8055 nm respectively. tcs 21311 exihibits inhibitory effect on gsk-3β, pkcα and pkcθ with the ic50 values of 3, 13 and 68 nm, respectively [1].janus kinases (jak) belong to a small family of cytoplasmic protein tyrosine kinases including jak1, jak2, tyk2, and jak3, which play important roles in initiating the cytokine-triggered signaling events by activators of transcription (stat) proteins via tyrosine phosphorylation [2]. due to its association with relevant cytokine signaling pathways, jak3 serves as an important target for therapeutic intervention in the treatment of inflammatory diseases, autoimmune disorders and organ transplant rejection [2].

IC 50

JAK3: 8 nM (IC50); JAK2: 2.55 μM (IC50); JAK1: 1.017 μM (IC50); PKCα: 13 nM (IC50); PKCθ: 68 nM (IC50); GSK-3β: 3 nM (IC50)

storage

Desiccate at RT

References

[1] thoma g, nuninger f, falchetto r, et al. identification of a potent janus kinase 3 inhibitor with high selectivity within the janus kinase family[j]. journal of medicinal chemistry, 2010, 54(1): 284-288.
[2] clark m p, george k m, bookland r g, et al. development of new pyrrolopyrimidine-based inhibitors of janus kinase 3 (jak3)[j]. bioorganic & medicinal chemistry letters, 2007, 17(5): 1250-1253.

TCS 21311 Preparation Products And Raw materials

Raw materials

Preparation Products

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TCS 21311 Suppliers

Canada 1 China 58 India 1 United Kingdom 1 United States 9 Global 70
Afflon Pharmaceutical (Sichuan) Co., Ltd.
Tel
17336178085
Email
1684779048@qq.com
Country
China
ProdList
2070
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58
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Chemsky (shanghai) International Co.,Ltd
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
15402
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60
Shanghai Sphchem Co., Ltd.
Tel
021-56491756 13512199871
Email
2819742715@qq.com
Country
China
ProdList
3999
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55
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-6206333 13167063860
Fax
021-50323701
Email
anhua.mao@aladdin-e.com
Country
China
ProdList
26658
Advantage
65
EMMX Biotechnology LLC
Tel
888-539-0666
Fax
888-539-0666
Email
info@emmx.com
Country
United States
ProdList
8447
Advantage
60
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9803
Advantage
58
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
86249
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60
Shanghai Rechem science Co., Ltd.
Tel
021-31433387 15618786686
Fax
QQ:1369748377
Email
sales@rechemscience.com
Country
China
ProdList
2982
Advantage
58
Shenzhen Polymeri Biochemical Technology Co., Ltd.
Tel
+86-400-002-6226 +86-13028896684;
Email
sales@rrkchem.com
Country
China
ProdList
57422
Advantage
58

1260181-14-3, TCS 21311Related Search:


  • 3-[5-[4-(2-Hydroxy-2-Methyl-1-oxopropyl)-1-piperazinyl]-2-(trifluoroMethyl)phenyl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione
  • TCS 21311
  • NIBR-3049
  • TCS21311; TCS-21311
  • JAK3/GSK-3β/PKCα Inhibitor - CAS 1260181-14-3 - Calbiochem
  • 3-{5-[4-(2-hydroxy-2-methylpropionyl)piperazin-1-yl]-2-trifluoromethylphenyl}-4-(1H-indol-3-yl)pyrrole-2,5-dione
  • 1H-Pyrrole-2,5-dione, 3-[5-[4-(2-hydroxy-2-methyl-1-oxopropyl)-1-piperazinyl]-2-(trifluoromethyl)phenyl]-4-(1H-indol-3-yl)-
  • Protein kinase C,TCS 21311,Glycogen synthase kinase 3,NIBR 3049,TCS21311,GSK-3,Glycogen synthase kinase-3,Inhibitor,JAK,inhibit,NIBR-3049,TCS-21311,Janus kinase,PKC
  • 3-(5-(4-(2-Hydroxy-2-methylpropanoyl)piperazin-1-yl)-2-(trifluoromethyl)phenyl)-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione
  • JAK3/GSK-3β/PKCα Inhibitor
  • 1260181-14-3
  • C27H25F3N4O4
  • Aromatics
  • Heterocycles
  • Inhibitors
  • Intermediates & Fine Chemicals
  • Pharmaceuticals