Cyenopyrafen Property

Boiling point:

489.1±45.0 °C(Predicted)

Density 

1.03±0.1 g/cm3(Predicted)

pka

2.61±0.10(Predicted)

Safety

Toxicity

Its oral LD50 in rats is 2000 mg/kg.

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H317May cause an allergic skin reaction

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P272Contaminated work clothing should not be allowed out of the workplace.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P321Specific treatment (see … on this label).

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

P363Wash contaminated clothing before reuse.

P391Collect spillage. Hazardous to the aquatic environment

P501Dispose of contents/container to..…

Cyenopyrafen Chemical Properties,Usage,Production

Description

Cyenopyrafen is a new acaricide for use in fruit, vegetables, and tea. Its oral LD50 in rats is 2000 mg/kg. Cyenopyrafen is also an inhibitor of mitochondrial complex II (Lummen, 2007).

Uses

Cyenopyrafen is part of the pyrazole class of fungicides and insecticide acting on ticks.

Definition

ChEBI: Cyenopyrafen is a member of the class of pyrazoles that is ethene in which the hydrogens at position 1 have been replaced by p-tert-butylphenyl and cyano groups, while the hydrogens at position 2 have been replaced by pivaloyloxy and 1,3,4-trimethylpyrazol-5-yl groups (the E isomer). A proacaricide (by hydrolysis of the pivalate ester linkage to give the corresponding enol), it was formerly used for the control of mites in fruit, vegetables and tea. It has a role as a proacaricide and an agrochemical. It is a nitrile, a pivalate ester and a member of pyrazoles.

Toxicology

Cyenopyrafen and cyflumetofen have been shown to have very low toxicity to mammals, birds, bees and beneficial insects, including predatory mites. They have some toxicity to fish and aquatic invertebrates, but pose minimal risk because they are rapidly degraded in water and soil.

Mode of action

Cyenopyrafen and cyflumetofen are pro-insecticides that are metabolized to corresponding enol products that inhibit mitochondrial electron transport complex II, leading to rapid paralysis and death due to cellular energy starvation. Resistance has not yet been reported.