ChemicalBook > CAS DataBase List > (R)-4-(1-aMinoethyl)-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)benzaMide dihydrochloride

(R)-4-(1-aMinoethyl)-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)benzaMide dihydrochloride

Product Name: (R)-4-(1-aMinoethyl)-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)benzaMide dihydrochloride
CAS No.: 173897-44-4
Chemical Name: (R)-4-(1-aMinoethyl)-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)benzaMide dihydrochloride
Synonyms: Y-33075 HCl;Y-33075 2HCl;Y 39983 2HCL;Y-39983 HCl ，S7935;Y 39983, 2 HCl salt;Y39983 HYDROCHLORIDE;Y39983 dihydrochlortide;Y-33075 (dihydrochloride);Y-33075 dihydrochloride, 10 mM in DMSO;(R)-4-(1-aMinoethyl)-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)benzaMide dihydrochloride
CBNumber: CB32554140
Molecular Formula: C16H18Cl2N4O
Formula Weight: 353.24632
MOL File: 173897-44-4.mol

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(R)-4-(1-aMinoethyl)-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)benzaMide dihydrochloride Property

storage temp.: Inert atmosphere,Room Temperature
solubility: Soluble in DMSO
form: Solid
color: White to gray
optical activity: [α]/D +5 to +9°, c =1 in methanol
InChI: InChI=1/C16H16N4O.2ClH/c1-10(17)11-2-4-12(5-3-11)16(21)20-14-7-9-19-15-13(14)6-8-18-15;;/h2-10H,17H2,1H3,(H2,18,19,20,21);2*1H/t10-;;/s3
InChIKey: CKFHAVRPVZNMGT-WTVPDBJGNA-N
SMILES: C(NC1C=CN=C2NC=CC2=1)(=O)C1=CC=C([C@H](N)C)C=C1.Cl.Cl |&1:16,r|

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML2920
Product name: Y-39983 dihydrochloride
Purity: ≥98% (HPLC)
Packaging: 5 mg
Price: $78.18
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML2920
Product name: Y-39983 dihydrochloride
Purity: ≥98% (HPLC)
Packaging: 25 mg
Price: $333
Updated: 2025/07/31

TRC

Product number: A594890
Product name: Y-39983Hydrochloride
Packaging: 2.5mg
Price: $220
Updated: 2021/12/16

ChemScene

Product number: CS-0096
Product name: Y-33075dihydrochloride
Purity: 97.34%
Packaging: 10mg
Price: $240
Updated: 2021/12/16

ApexBio Technology

Product number: B1176
Product name: Y-39983dihydrochloride
Packaging: 10mg
Price: $315
Updated: 2021/12/16

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(R)-4-(1-aMinoethyl)-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)benzaMide dihydrochloride Chemical Properties,Usage,Production

Uses

Y-39983 Hydrochloride contain Rho kinase inhibitory activity.

Biological Activity

y-39983 dihydrochloride is a novel and selective inhibitor of rock family with ic50 value of 3.6nm for rock [1].y-39983 dihydrochloride has shown a selective inhibitor of rho-associated coiled coil-forming protein kinase( rock ) with ic50 values of 3.6nm, 0.42μm and 0.81μm for rock, pkc and camkii, respectively [1]. apart from these, y-39983 has been reported to relax the ciliary arteries of precontracted isolated rabbit in vitro. in addition, y-39983 has been found to increase optic-nerve-head blood flow by laser speckle flowmetry [2]. moreover, y-39983 lowered the intraocular pressure ( iop) in a dose-dependent fashion in the eyes of rabbits and monkeys [1].

in vivo

In rabbits, Y-39983 (≥0.01%) significantly lowers intraocular pressure (IOP) at 2 hours after topical administration. In monkeys, Y-39983 (0.05%)-treated eyes show significant reduction of IOP between 2 and 7 hours after topical administration^[1]. Y-39983 (100 μM) increases the regenerating axons of retinal ganglion cells (RGCs) in the eyes of the rats^[2].

IC 50

ROCK: 3.6 nM (IC₅₀); PKC: 420 nM (IC₅₀); CaMKII: 810 nM (IC₅₀)

References

[1] tokushige h1, inatani m, nemoto s, sakaki h, katayama k, uehata m, tanihara h. effects of topical administration of y-39983, a selective rho-associated protein kinase inhibitor, on ocular tissues in rabbits and monkeys. invest ophthalmol vis sci. 2007 jul;48(7):3216-22.
[2] watabe h1, abe s, yoshitomi t. effects of rho-associated protein kinase inhibitors y-27632 and y-39983 on isolated rabbit ciliary arteries. jpn j ophthalmol. 2011 jul;55(4):411-7. doi: 10.1007/s10384-011-0048-9. epub 2011 jun 11.

(R)-4-(1-aMinoethyl)-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)benzaMide dihydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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(R)-4-(1-aMinoethyl)-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)benzaMide dihydrochloride Suppliers

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173897-44-4, (R)-4-(1-aMinoethyl)-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)benzaMide dihydrochlorideRelated Search:

Y27632 (hydrochloride) N-[(3S,4R)-6-CYANO-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-2H-1-BENZOPYRAN-4-YL]-N-HYDROXYACETAMIDE Y320 (R)-4-(1-Aminoethyl)-N-1H-pyrrolo[2,3-b]pyridin-4-ylbenzamide Y-27632 DIHYDROCHLORIDE

(R)-4-(1-aMinoethyl)-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)benzaMide dihydrochloride

Y-33075 (dihydrochloride)

Y 39983 2HCL

Y-33075 2HCl

Y 39983, 2 HCl salt

Y39983 HYDROCHLORIDE

Y-33075 HCl

Y39983 dihydrochlortide

Y33075 dihydrochloride,ROCK,Y33075,Y 33075,ROK,Rho-associated kinase,Inhibitor,Rho-associated protein kinase,Y 33075 dihydrochloride,Rho-kinase,inhibit,Y-33075

Y-33075 dihydrochloride, 10 mM in DMSO

Y-39983 HCl ，S7935

173897-44-4

C16H18Cl2N4O

C16H16N4O2HCl