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BML-286

Product Name
BML-286
CAS No.
294891-81-9
Chemical Name
BML-286
Synonyms
BML-286;2-[[3-[(phenylacetyl)aMino]benzoyl]aMino]benzoic Acid;2-[[3-[(2-phenylacetyl)aMino]benzoyl]aMino]benzoic Acid;Benzoic acid, 2-[[3-[(2-phenylacetyl)amino]benzoyl]amino]-;Dvl-PDZ Domain Inhibitor II - CAS 294891-81-9 - Calbiochem
CBNumber
CB32557989
Molecular Formula
C22H18N2O4
Formula Weight
374.39
MOL File
294891-81-9.mol
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BML-286 Property

storage temp. 
+2C to +8C
form 
White solid
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
322338
Product name
Dvl-PDZ Domain Inhibitor II - CAS 294891-81-9 - Calbiochem
Packaging
10mg
Price
$144
Updated
2024/03/01
TRC
Product number
B595870
Product name
BML-286
Packaging
50mg
Price
$165
Updated
2021/12/16
Usbiological
Product number
004331
Product name
BML-286
Packaging
50mg
Price
$460
Updated
2021/12/16
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BML-286 Chemical Properties,Usage,Production

Uses

BML-286 is a small molecule inhibitor of the PDZ domain of Dishevelled (Dvl): an essential protein in the Wnt signaling pathways. This compound reduced the levels of apoptosis in the hyaloid vessels of the eye and also suppressed the growth of prostate cancer PC-3 cells. It is a useful tool for studies dissecting the Wnt signaling pathways.

Definition

ChEBI: 2-[[oxo-[3-[(1-oxo-2-phenylethyl)amino]phenyl]methyl]amino]benzoic acid is a member of benzamides.

General Description

A cell-permeable amidobenzanilide compound that disrupts Fz-Dvl (frizzled-dishevelled) interaction by targeting the PDZ domain (Kd = 10.6 μM) of Dvl, blocking Wnt3a-induced (10 ng/ml) transcription activity (~50% inhibition at 3 μM in 293 cell SuperTopflash reporter assays) and suppressing the Wnt pathway-dependent growth of prostate cancer PC-3 cells (by 16% in 72 h at ≥50 μM; IC50 = 12.5 μM). Shown to effectively prevent Wnt3A mRNA injection-induced xenopus embryo deformation (effective conc. = 25 μM) and suppress Wnt pathway-mediated apoptosis of the hyaloid vescular endothelial cells in the mouse eyes via vitreous injection (144 fmol/120 nl/eye) in vivo.

BML-286 Preparation Products And Raw materials

Raw materials

Preparation Products

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BML-286 Suppliers

Canada 1 China 19 United States 2 Global 22
Toronto Research Chemicals
Tel
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Fax
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Email
info@trc-canada.com
Country
Canada
ProdList
6038
Advantage
71

294891-81-9, BML-286Related Search:

2-[(4-Acetylphenyl)azo]-2-(3,4-dihydro-3,3-diMethyl-1(2H)- isoquinolinylidene)acetaMide α-(4-Chlorophenyl)-2-Methyl-N-2-pyridinyl-1H-indole-3-MethanaMine

  • 2-[[3-[(2-phenylacetyl)aMino]benzoyl]aMino]benzoic Acid
  • 2-[[3-[(phenylacetyl)aMino]benzoyl]aMino]benzoic Acid
  • BML-286
  • Dvl-PDZ Domain Inhibitor II - CAS 294891-81-9 - Calbiochem
  • Benzoic acid, 2-[[3-[(2-phenylacetyl)amino]benzoyl]amino]-
  • 294891-81-9
  • Aromatics
  • Inhibitors
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Aromatics, Inhibitors, Pharmaceuticals, Intermediates & Fine Chemicals