α-(4-Chlorophenyl)-2-Methyl-N-2-pyridinyl-1H-indole-3-MethanaMine

Product Name: α-(4-Chlorophenyl)-2-Methyl-N-2-pyridinyl-1H-indole-3-MethanaMine
CAS No.: 305372-78-5
Chemical Name: α-(4-Chlorophenyl)-2-Methyl-N-2-pyridinyl-1H-indole-3-MethanaMine
Synonyms: CCT036477;Wnt Pathway Inhibitor XI, CCT036477;N-((4-chlorophenyl)(2-methyl-1H-indol-3-yl)methyl)pyridin-2-amine;α-(4-Chlorophenyl)-2-Methyl-N-2-pyridinyl-1H-indole-3-MethanaMine;Wnt Pathway Inhibitor XI, CCT036477 - CAS 305372-78-5 - Calbiochem;1H-Indole-3-methanamine, α-(4-chlorophenyl)-2-methyl-N-2-pyridinyl-
CBNumber: CB12621741
Molecular Formula: C21H18ClN3
Formula Weight: 347.84
MOL File: 305372-78-5.mol

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α-(4-Chlorophenyl)-2-Methyl-N-2-pyridinyl-1H-indole-3-MethanaMine Property

Melting point:: >167°C (dec.)
Boiling point:: 546.0±45.0 °C(Predicted)
Density: 1.301±0.06 g/cm3(Predicted)
storage temp.: -20°C
solubility: DMSO: ≥20mg/mL (warm to 60°C)
pka: 17.33±0.30(Predicted)
form: powder
color: white to tan
Stability:: Light Sensitive

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0151
Product name: CCT036477
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $121
Updated: 2025/07/31

Sigma-Aldrich

Product number: 681674
Product name: Wnt Pathway Inhibitor XI, CCT036477
Packaging: 5mg
Price: $150
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML0151
Product name: CCT036477
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $318
Updated: 2025/07/31

Usbiological

Product number: 005838
Product name: CCT036477
Packaging: 25mg
Price: $446
Updated: 2021/12/16

TRC

Product number: C227900
Product name: CCT036477
Packaging: 25mg
Price: $135
Updated: 2021/12/16

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α-(4-Chlorophenyl)-2-Methyl-N-2-pyridinyl-1H-indole-3-MethanaMine Chemical Properties,Usage,Production

Uses

CCT036477 is an inhibitor of Wnt signaling. Studies show that CCT036477 does not alter β-catenin levels but blocks transcription at the β-catenin level. CCT036477 inhibited growth in several cancer cell lines and showed clear activity in vivo, blocking development of Zebrafish and Xenopus embryos and expression of Wnt target genes.

Definition

ChEBI: N-[(4-chlorophenyl)-(2-methyl-1H-indol-3-yl)methyl]-2-pyridinamine is a member of indoles.

Biological Activity

CCT036477 is an inhibitor of Wnt signaling. It does not alter β-catenin levels but blocks transcription at the β-catenin level. CCT036477 inhibited growth in several cancer cell lines and showed clear activity in vivo, blocking development of Zebrafish and Xenopus embryos and expression of Wnt target genes.

α-(4-Chlorophenyl)-2-Methyl-N-2-pyridinyl-1H-indole-3-MethanaMine Preparation Products And Raw materials

Raw materials

Preparation Products

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α-(4-Chlorophenyl)-2-Methyl-N-2-pyridinyl-1H-indole-3-MethanaMine Suppliers

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305372-78-5, α-(4-Chlorophenyl)-2-Methyl-N-2-pyridinyl-1H-indole-3-MethanaMineRelated Search:

2-[(4-Acetylphenyl)azo]-2-(3,4-dihydro-3,3-diMethyl-1(2H)- isoquinolinylidene)acetaMide BML-286

CCT036477

α-(4-Chlorophenyl)-2-Methyl-N-2-pyridinyl-1H-indole-3-MethanaMine

Wnt Pathway Inhibitor XI, CCT036477

N-((4-chlorophenyl)(2-methyl-1H-indol-3-yl)methyl)pyridin-2-amine

Wnt Pathway Inhibitor XI, CCT036477 - CAS 305372-78-5 - Calbiochem

1H-Indole-3-methanamine, α-(4-chlorophenyl)-2-methyl-N-2-pyridinyl-

305372-78-5

Aromatics, Heterocycles, Indole Deribatives, Inhibitors, Pharmaceuticals, Intermediates & Fine Chemicals