Vilanterol Trifenatate

ChemicalBook > CAS DataBase List > Vilanterol Trifenatate

Vilanterol Trifenatate

Product Name: Vilanterol Trifenatate
CAS No.: 503070-58-4
Chemical Name: Vilanterol Trifenatate
Synonyms: vilanterol trifenatate;Vilanterol Trifenate;Vilanterol triphenylacetate;GW642444M;GW 642444M;GW-642444M;GW642444M Trifenate;GW642444 (trifenatate);Vilanterol Trifenatate (API);GW642444M; GW 642444M; GW-642444M
CBNumber: CB32563287
Molecular Formula: C44H49Cl2NO7
Formula Weight: 774.78
MOL File: 503070-58-4.mol

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Vilanterol Trifenatate Property

Melting point:: 131.9-134.2℃
storage temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility: Dichloromethane (Slightly), Methanol (Slightly)
form: Solid
color: White to Off-White
Stability:: Hygroscopic

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML3389
Product name: Vilanterol trifenatate
Purity: ≥95% (HPLC)
Packaging: 10MG
Price: $86.5
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML3389
Product name: Vilanterol trifenatate
Purity: ≥95% (HPLC)
Packaging: 50MG
Price: $350
Updated: 2024/03/01

TRC

Product number: V260000
Product name: VilanterolTrifenatate
Packaging: 5mg
Price: $225
Updated: 2021/12/16

ChemScene

Product number: CS-1679
Product name: Vilanterol(trifenatate)
Purity: 99.20%
Packaging: 5mg
Price: $100
Updated: 2021/12/16

ChemScene

Product number: CS-1679
Product name: Vilanterol(trifenatate)
Purity: 99.20%
Packaging: 10mg
Price: $150
Updated: 2021/12/16

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Vilanterol Trifenatate Chemical Properties,Usage,Production

Chemical Properties

Vilanterol trifenatate is a white powder with a molecular weight of 774.8, and the empirical formula is C24H33Cl2NO5.C20H16O2. It insoluble in water and slightly soluble in methanol, ethanol, acetonitrile and propan-2-ol. It is slightly hygroscopic. It is provided in a micronized form.

Uses

Vilanterol Trifenatate is a long-acting β2 adrenergic receptor Agonist with alonger than 24-hour activity in humans, and is being developed to be used in combination with FF. It is also highly selective for the β2-receptor, with over 1000-fold greater selectivity compared to β1-receptors. It demonstrates prolonged bronchodilation in subjects with asthma and COPD.

Preparation

Vilanterol trifenatate is synthesized by incorporation of an oxygen atom at the homobenzylic position of the right-hand side phenyl ring of (R)-salmeterol and has suitable chemical properties for inhaled administration. The combination in fluticasone furoate (FF) and vilanterol trifenatate (VI) in a single inhaler is the first once daily combination available on the market for the treatment of stable COPD.

Definition

ChEBI: Vilanterol Trifenatate is a triphenylacetate salt obtained by combining vilanterol with one equivalent of triphenylacetic acid. Used in combination with fluticasone furoate for treatment of bronchospasm associated with chronic obstructive pulmonary disease. It has a role as a beta-adrenergic agonist and a bronchodilator agent. It contains a vilanterol(1+).

Biological Activity

vilanterol trifenatate is a novel and selective agonist of β2-ar with a pec50 value of 10.37±0.05 [1].vilanterol trifenatate is a novel long-acting β2-ar agonist (laba) with 24h activity in development for inhaled once daily treatment. in the radioligand binding studies, vilanterol trifenatate has shown the binding affinity in the one-affinity site model with pkd values of 9.44±0.07 and 10.82±0.12 in the presence gpp(nh)p and absence gpp(nh)p, respectively. in dissociation studies, vilanterol trifenatate has been reported to bind from the β2-ar with a dissociation t1/2 value of 3.5 min in the presence of gpp(nh)p. vilanterol trifenatate has been found to have a good selectivity for β2-ar over the other β-ar receptor subtypes(β1and β3) with pec50 values of 10.37±0.05, 6.98±0.03 and 7.36±0.03, respectively. vilanterol trifenatate has exhibited at least 1000-fold selectivity over both β1-and β3-ar subtypes [1].

Dosage

The recommended and maximum dose is one inhalation of vilanterol trifenatate 25 micrograms once daily either morning or evening but at the same time every day.

Mode of action

Vilanterol Trifenatate is a selective long-acting beta2-receptor agonist (also referred to as a LABA). The pharmacologic effects of beta2-adrenoceptor agonist drugs, including vilanterol trifenatate, are at least in part attributable to stimulation of intracellular adenylate cyclase, the enzyme that catalyses the conversion of adenosine triphosphate (ATP) to cyclic-3',5'-adenosine monophosphate (cyclic AMP). Increased cyclic AMP levels cause relaxation of bronchial smooth muscle and inhibition of release of mediators of immediate hypersensitivity from cells, especially from mast cells.

References

[1] slack rj1, barrett vj, morrison vs, sturton rg, emmons aj, ford aj, knowles rg.in vitro pharmacological characterization of vilanterol, a novel long-acting β2-adrenoceptor agonist with 24-hour duration of action.j pharmacol exp ther. 2013 jan; 344(1):218-30.

Vilanterol Trifenatate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Vilanterol Trifenatate manufacturers

Zibo Hangyu Biotechnology Development Co., Ltd

Product: Vilanterol Trifenatate 503070-58-4
Price: US $70.00-700.00/kg
Min. Order: 10kg
Purity: 0.99
Supply Ability: 20tons
Release date: 2023-11-20

Wuhan Xinhao Biotechnology Co., Ltd

Product: Vilanterol Trifenatate 503070-58-4
Price: US $10.00-100.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100 tons
Release date: 2024-03-11

PNP Biotech Co. Ltd

Product: Vilanterol 503070-58-4
Price: US $0.00/KG
Min. Order: 25KG
Purity: 99%
Supply Ability: Inquiry
Release date: 2022-10-26

503070-58-4, Vilanterol TrifenatateRelated Search:

Carbamic acid, N-[2-(2,2-dimethyl-4H-1,3-benzodioxin-5-yl)-2-oxoethyl]-, 1,1-dimethylethyl ester Benzaldehyde, 5-[(1R)-2-[[6-[2-[(2,6-dichlorophenyl)methoxy]ethoxy]hexyl]amino]-1-hydroxyethyl]-2-hydroxy- Phenylacetyl chloride 1,4-Phenylenediacetic acid Ethylenediaminetetraacetic acid Vilanterol Vilanterol Impurity 14 Vilanterol Impurity 22(Vilanterol-d4 Triphenylacetate) Vilanterol Impurity 3 Triphenylacetate Vilanterol Impurity 6 Triphenylacetate 5-(2,2-diMethyl-4H-benzo[d][1,3]dioxin-6-yl)oxazolidin-2-one Vilanterol Impurity 23 Vilanterol Impurity 7 Triphenylacetate Vilanterol Impurity 25 (1R)-2-[[6-[2-[(2,6-Dichlorobenzyl)oxy]ethoxy]hexyl]aMino]-1-(2,2-diMethyl-4H-1,3-benzodioxin-6-yl)ethanol

Vilanterol triphenylacetate

GW642444M; GW 642444M; GW-642444M

Benzeneacetic acid, α,α-diphenyl-, coMpd. with (α1R)-α1-[[[6-[2-[(2,6-dichlorophenyl)Methoxy]ethoxy]hexyl]aMino]Methyl]-4-hydroxy-1,3-benzenediMethanol (1:1)

vilanterol trifenatate

GW 642444M

GW642444M

GW-642444M

Vilanterol Trifenatate (API)

4-[(R)-2-[[6-[2-(2,6-Dichlorobenzyloxy)ethoxy]hexyl]amino]-1-hydroxyethyl]-2-(hydroxymethyl)phenol triphenylacetate

Vilanterol Trifenate

Benzeneacetic acid, α,α-diphenyl-, coMpd. with (α1R)-α1-6-2-(2,6-dichlorophenyl)MethoxyethoxyhexylaMinoMethyl-4-hydroxy-1,3-benzenediMethanol (1

GW642444 (trifenatate)

(R)-4-(2-((6-(2-((2,6-dichlorobenzyl)oxy)ethoxy)hexyl)amino)-1-hydroxyethyl)-2-(hydroxymethyl)phenyl 2,2,2-triphenylacetate

Pharmaceuticals Chemical Vilanterol Trifenatate Powder

Benzeneacetic acid, α,α-diphenyl-, coMpd. with (α1R)-α1-[[[6-[2-[(2,6-dichlorophenyl)Methoxy]ethoxy]hexyl]aMino]Methyl]-4-hydroxy-1,3-benzenediMethanol (1

GW642444M Trifenate

(R)-4-(2-((6-(2-((2,6-dichlorobenzyl)oxy)ethoxy)hexyl)amino)-1-hydroxyethyl)-2-(hydroxymethyl)phenol2,2,2-triphenylacetate

Vilanterol TrifenatateQ: What is Vilanterol Trifenatate Q: What is the CAS Number of Vilanterol Trifenatate Q: What is the storage condition of Vilanterol Trifenatate Q: What are the applications of Vilanterol Trifenatate

Benzeneacetic acid, α,α-diphenyl-, coMpd. with (α1R)-α1-[[[6-[2-[(2,6-dichlorophenyl)Methoxy]ethoxy]hexyl]aMino]Methyl]-4-hydroxy-1,3-benzenediMethanol (1:1)

503070-58-4 Benzeneacetic acid, α,α-diphenyl-, coMpd. with (α1R)-α1-[[[6-[2-[(2,6-dichlorophenyl)Methoxy]ethoxy]hexyl]aMino]Methyl]-4-hydroxy-1,3-benzenediMethanol (1:1)

VilanterolImpurity8Triphenylacetate

1-(3-(6-((pyridin-3-ylmethyl)amino)-1H-pyrrolo[2,3-b]pyridin-4-yl)phenyl)ethan-1-ol

503070-58-4

C44H49Cl2NO7

C24H33Cl2NO5C20H16O2

Intermediate

503070-58-4