Onalespib

Product Name: Onalespib
CAS No.: 912999-49-6
Chemical Name: Onalespib
Synonyms: CS-1866;AT-13387;ATI13387X;Onalespib;ATI-13387;AT13387, >=98%;Onalespib Lactate;AT13387(Onalespib);Onalespib (AT13387);ONALESPIB;ATI-13387
CBNumber: CB32566420
Molecular Formula: C24H31N3O3
Formula Weight: 409.52
MOL File: 912999-49-6.mol

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Onalespib Property

Boiling point:: 605.7±55.0 °C(Predicted)
Density: 1.237
storage temp.: Store at -20°C
solubility: insoluble in H2O; ≥13.25 mg/mL in DMSO; ≥47.7 mg/mL in EtOH with ultrasonic
form: solid
pka: 8.50±0.48(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 10655
Product name: Onalespib
Purity: ≥98%
Packaging: 1mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 10655
Product name: Onalespib
Purity: ≥98%
Packaging: 5mg
Price: $151
Updated: 2024/03/01

Cayman Chemical

Product number: 10655
Product name: Onalespib
Purity: ≥98%
Packaging: 10mg
Price: $278
Updated: 2024/03/01

Cayman Chemical

Product number: 10655
Product name: Onalespib
Purity: ≥98%
Packaging: 25mg
Price: $586
Updated: 2024/03/01

Biosynth Carbosynth

Product number: FA145338
Product name: AT-13387
Packaging: 25mg
Price: $595
Updated: 2021/12/16

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Onalespib Chemical Properties,Usage,Production

Description

Onalespib, also known as AT13387, is a selective inhibitor of Hsp90 (IC50 = 18 nM). It induces the degradation of specific Hsp90 client proteins, including mutant EGFR, for up to seven days in tumor cell lines in vitro and up to three days in vivo. Onalespib is retained in tumor xenografts and is efficacious in a range of xenograft models. It differs from other HSP90 inhibitors in its longer duration of target inhibition and its favorable toxicity profile in phase I studies in patients with refractory solid tumors.

Definition

ChEBI: Onalespib is a member of the class of isoindoles that is isoindole in which the amino group has been acylated by a 2,4-dihydroxy-5-isopropylbenzoyl group and in which position 5 of the isoidole moiety has been substituted by a (4-methylpiperazin-1-yl)methyl group. A second-generation Hsp90 inhibitor. It has a role as a Hsp90 inhibitor and an antineoplastic agent. It is a member of resorcinols, a member of benzamides, a tertiary carboxamide, a member of isoindoles and a N-alkylpiperazine.

target

Hsp90

Mode of action

Onalespib selectively binds to Hsp90, thereby inhibiting its chaperone function and promoting the degradation of oncogenic signaling proteins involved in tumor cell proliferation and survival. Hsp90, a chaperone protein upregulated in a variety of tumor cells, regulates the folding, stability and degradation of many oncogenic signaling proteins and has been used as a biomarker of HSP90 inhibition.

References

Efficacy of Onalespib, a Long-Acting Second-Generation HSP90 Inhibitor, as a Single Agent and in Combination with Temozolomide against Malignant Gliomas
https://pubchem.ncbi.nlm.nih.gov/compound/Onalespib

Onalespib Preparation Products And Raw materials

Raw materials

Preparation Products

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Onalespib Suppliers

China 97 India 1 United Kingdom 1 United States 15 Global 114

AdooQ BioScience, LLC

Tel: +1 (866) 930-6790
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ApexBio Technology LLC

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Target molecule Corp.

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Musechem

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TargetMol Chemicals Inc.

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InvivoChem

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Cckinase, Inc.

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Country: United States
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BOC Sciences

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Aladdin Scientific

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TargetMol Chemicals Inc.

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ApexBio Technology

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Cayman Chemical Company

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Creative Enzymes

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Selleck Chemicals LLC

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Santa Cruz Biotechnology, Inc.

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912999-49-6, OnalespibRelated Search:

Bortezomib BIIB-021 4-(6,6-dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-((1r,4r)-4-hydroxycyclohexylamino)benzamide PU-H71 Flavopiridol (Alvocidib) HCl Ganetespib

(2,4-dihydroxy-5-isopropylphenyl)(5-((4-Methylpiperazin-1-yl)Methyl)isoindolin-2-yl)Methanone

AT-13387

4-({5-[(4-Methylpiperazin-1-yl)Methyl]-2,3-dihydro-1H-isoindol-2-yl}carbonyl)-6-(propan-2-yl)benzene-1,3-diol

[1,3-Dihydro-5-[(4-methyl-1-piperazinyl)methyl]-2H-isoindol-2-yl][2,4-dihydroxy-5-(1-methylethyl)phenyl]methanone

Onalespib

Onalespib (AT13387)

[1,3-Dihydro-5-[(4-methyl-1-piperazinyl)methyl]-2H-isoindol-2-yl][2,4-dihydroxy-5-(1-methylethyl)phenyl]methanone AT13387

AT13387, >=98%

Onalespib Lactate

ATI13387X

CS-1866

AT13387(Onalespib)

(2,4-dihydroxy-5-propan-2-ylphenyl)-[5-[(4-methylpiperazin-1-yl)methyl]-1,3-dihydroisoindol-2-yl]methanone

ATI-13387

ONALESPIB;ATI-13387

Methanone, [1,3-dihydro-5-[(4-methyl-1-piperazinyl)methyl]-2H-isoindol-2-yl][2,4-dihydroxy-5-(1-methylethyl)phenyl]-

(2,4-dihydroxy-5-isopropylphenyl)(5-((4-Methylpiperazin-1-yl)Methyl)isoindolin-2-yl)Methanone USP/EP/BP

Onalespib AT-13387 AT13387

912999-49-6

12999-49-6

Inhibitor

Inhibitors