ChemicalBook > CAS DataBase List > L-Octahydroindole-2-carboxylic acid

L-Octahydroindole-2-carboxylic acid

Product Name
L-Octahydroindole-2-carboxylic acid
CAS No.
80875-98-5
Chemical Name
L-Octahydroindole-2-carboxylic acid
Synonyms
(2S,3aS,7aS)-Octahydro-1H-indole-2-carboxylic acid;(2S,3aS,7aS)-Octahydro-2-indolecarboxylicacid;(2S,3αS,7αS)-Octahydro-1H-indole-2-carboxylic acid;(2R,3aR,7aR)-octahydro-1H-indole-2-carboxylic acid;L-Oic-OH;Perindopril Related Compound 7;OCTAHYDRO-INDOLE-2-CARBOXYLIC ACID;L-(2S,3aS,7aS)-Octahydroindole-2-carboxylic Acid;1H-Indole-2-carboxylicacid,octahydro-,(2S,3aS,7aS)-(9CI);Compound 80875-98-5
CBNumber
CB3258000
Molecular Formula
C9H15NO2
Formula Weight
169.22
MOL File
80875-98-5.mol
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L-Octahydroindole-2-carboxylic acid Property

Melting point:
275-277°C
Boiling point:
318.6±25.0 °C(Predicted)
Density 
1.135±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
Methanol (Sparingly), Water (Slightly)
pka
2.47±0.20(Predicted)
color 
White to Off-White
PH
-50 (c=1 in methanol)
Water Solubility 
Soluble in methanol and water.
InChI
InChI=1S/C9H15NO2/c11-9(12)8-5-6-3-1-2-4-7(6)10-8/h6-8,10H,1-5H2,(H,11,12)/t6-,7-,8-/m0/s1
InChIKey
CQYBNXGHMBNGCG-FXQIFTODSA-N
SMILES
N1[C@]2([H])[C@@]([H])(CCCC2)C[C@H]1C(O)=O
LogP
0.3 at 25℃ and pH5
CAS DataBase Reference
80875-98-5(CAS DataBase Reference)
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Safety

Risk Statements 
36/37/38
Safety Statements 
26-37
HS Code 
29339900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
Y0000237
Product name
Perindopril impurity A
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
15 mg
Price
$156
Updated
2025/07/31
Sigma-Aldrich
Product number
PHR3078
Product name
Perindopril Related Compound A
Purity
pharmaceutical secondary standard, certified reference material
Packaging
50MG
Price
$592
Updated
2025/07/31
Sigma-Aldrich
Product number
Y0000237
Product name
Perindopril impurity A
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
y0000237
Price
$153
Updated
2024/03/01
Sigma-Aldrich
Product number
1510890
Product name
Perindopril Related Compound A
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
0
Price
$0
Updated
2021/12/16
TCI Chemical
Product number
O0370
Product name
(2S,3aS,7aS)-Octahydro-1H-indole-2-carboxylic Acid
Purity
>98.0%(GC)(T)
Packaging
1g
Price
$49
Updated
2025/07/31
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L-Octahydroindole-2-carboxylic acid Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

An intermediate in the synthesis of Perindopril. Perindopril USP Related Compound A.

Synthesis

539820-41-2

80875-98-5

General procedure for the synthesis of L-octahydroindole-2-carboxylic acid from the compound (CAS: 539820-41-2): 200 g of the compound obtained in the previous step was dissolved in acetic acid, followed by the addition of 5 g of 10% Pt/C catalyst to the hydrogenator. The hydrogenation reaction was carried out at room temperature and 5 bar hydrogen pressure until a theoretical amount of hydrogen was absorbed. Upon completion of the reaction, the catalyst was removed by filtration and the resulting solid product was collected by filtration after the reaction solution was cooled to 0 to 5 °C. The reaction was carried out at room temperature and 5 bar hydrogen pressure. The filter cake was washed with a suitable solvent and dried under constant weight conditions. The final product was (2S,3aS,7aS)-octahydroindole-2-carboxylic acid in 87% yield and 99% enantiomeric purity.

References

[1] Patent: US2006/167273, 2006, A1. Location in patent: Page/Page column 2

L-Octahydroindole-2-carboxylic acid Preparation Products And Raw materials

Raw materials

Preparation Products

Perindopril
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View Lastest Price from L-Octahydroindole-2-carboxylic acid manufacturers

Hebei Zhuanglai Chemical Trading Co Ltd
Product
L-Octahydroindole-2-Carboxylic Acid 80875-98-5
Price
US $50.00/kg
Min. Order
1kg
Purity
99
Supply Ability
5000
Release date
2024-12-06
Baoji Guokang Healthchem Co., Ltd.
Product
L-Octahydroindole-2-carboxylic acid 80875-98-5
Price
US $793.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10000KG
Release date
2021-06-07
Hebei Chuanghai Biotechnology Co,.LTD
Product
L-Octahydroindole-2-Carboxylic Acid 80875-98-5
Price
US $5.00-2.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10000kg
Release date
2024-08-23

80875-98-5, L-Octahydroindole-2-carboxylic acidRelated Search:

Hyaluronic acid Indometacin cis-Octahydro-isoindole Indole-3-butyric acid Folic acid Indole-2-carboxylic acid Indole-3-acetic acid Ethyl 2-(Chlorosulfonyl)acetate Perindoprilat Ethyl L-octahydroindole-2-carboxylate hydrochloride (2S,3aR,7aS)-1H-Octahydroindole-2-carboxylic acid hydrochloride Perindopril Citric acid Perindopril erbumine Perindopril-N-desethylpentanoate 1H-Indole-2-carboxylicacid,2,3,4,5,6,7-hexahydro-,(2S)-(9CI) (R)-N-(1-Carboxyethyl)-D-norvaline 1-Ethyl Ester Perindopril EP Impurity L

  • OCTAHYDRO-INDOLE-2-CARBOXYLIC ACID
  • (2S,3αS,7αS)-Octahydro-1H-indole-2-carboxylic acid
  • [2S-(2a,3ab,7ab)]-Octahydro-1H-indole-2-carboxylic Acid
  • L-(2S,3aS,7aS)-Octahydroindole-2-carboxylic Acid
  • (2s,3as,7as)-Octahydro-1h-Indo
  • 1H-Indole-2-carboxylicacid,octahydro-,(2S,3aS,7aS)-(9CI)
  • (2S,3aS,7aS)-2-Carboxyperhydroindole
  • (2S,3aS,7aS)-Octahydro-1H-indole-2-carboxylic acid
  • L-2-carboxyoctahydroindole
  • (2S,3aS,7aS)-1-Octahydro-1H-indole-2-car
  • (2S,3aS,7aS)-Octahydro-2-indolecarboxylicacid
  • (2s，3as，7as)-octabyche-lh-indole-2-carboxylicacid
  • L-Octahydroindole-2-carboxylic acid≥ 98% (HPLC)
  • L-Oic-OH
  • 2S,3AS,7AS)-OCTAHYDRO-1H-INDOLE-2-CARBOXYLIC ACID(RE-EXP/IMPTD VDE BE N.9512629/9.6.15 P.NO.V/30/02/15/MISC/1 D.29.11.15
  • Perindopril Impurity 1(Perindopril EP Impurity A )
  • (2S,3As,7As)Octahydro-1H Indole-2-Carboxylic Acid (Ohi Acid)
  • (2S,3AS,7AS)-2-Carboxyoctahydroindole octahydro-1H-indole-2-carboxylic acid
  • Perindopril related compounds 7
  • [2S-(2a,3a,7a)]-Octahydro-1H-indole-2-carboxylic Acid
  • L-Octahydroindole-2-carboxylic acid ,98%
  • (2S,3aS,7aS)-2,3,3aβ,4,5,6,7,7aβ-Octahydro-1H-indole-2α-carboxylic acid
  • [2S,3aβ,7aβ,(-)]-Octahydro-1H-indole-2α-carboxylic acid
  • (2S,3aR,7aR)-2,3,3aα,4,5,6,7,7aα-Octahydro-1H-indole-2α-carboxylic acid
  • (2S,3aS,7As)-Octanhydro-1H-Indole-2-Carboxylic Acid
  • L-Octahydroindole-2-
  • Perindopril Intermediate 3
  • (2S,3aS,7aS)-Octahydro-1H-indole-2-carboxylic acid (InterMediates for Perindopril)
  • [2S-(2α,3aβ,7aβ)]-Octahydro-1H-indole-2-carboxylic Acid
  • H-Oic-OH, (2S,3aS,7aS)-1-Octahydro-1H-indole-2-carboxylic acid
  • 1H-Indole-2-carboxylicacid, octahydro-, (2S,3aS,7aS)-
  • (2S,3aS,7aS)-OCLahydroindole-2-Carboxylic Acid
  • (2α,3aβ,7aβ)-octahydro-1H-indole-2-carboxylic acid
  • Perindopril EP IMpurity-A (USP RC A)
  • Perindopril EP IMpurity A
  • Perindopril Related CoMpound A
  • (2S,3aS,7aS)-Octahydroindole-2-carboxylicacid,98%
  • perindopril impurity
  • (S)-Octahydroindole-2-carboxylic acid
  • Ramipril Bicyclic Acid
  • Perindopril Related Compound 7
  • (2R,3aR,7aR)-octahydro-1H-indole-2-carboxylic acid
  • Perindopril tert-Butylamine Impurity Ⅰ:L-(2S,3aS,7aS)-Octahydroindole-2-carboxylic Acid
  • (2S,3aS,7aS)-Octahydro-1H-indole-2-
  • Perindopril impurity A CRS
  • (2S,3aS,7aS)-Octahydro-1H-indole-2-carboxylicAcid&gt
  • (2S,3aS,7aS)-Octahydro-1H-indole-2-carboxylic acid(PER-6)
  • L-octahydroindole dicarboxylic acid
  • Perindopril EP Impurity A/Perindopril USP RC- A
  • Perindopril EP Impurity A (Ramipril Bicyclic Acid)
  • Ramipril Bicyclic Acid (Perindopril EP Impurity A)
  • Perindopril Related Compound A ((2S,3aS,7aS)-octahydro-1H-indole-2-carboxylic acid) (1510890)
  • perindopril impurity Ⅰ 〔 (2S,3aS,7aS)-octahydro-1H-i ndole-2-carboxylic acid〕
  • L-Octahydroindole-2-carboxylic
  • (2S,3αS,7αS)-Octahydro-1H-indole-2-carboxylicacid
  • Perindopril USP Related Compound A
  • (2S,3aS,7aS)-Octahydroindole-2-carboxylicaci
  • L-Octahydroindole-2-carboxylic acid /(2S,3aS,7aS)-Octahydro-1H-indole-2-carboxylic Acid