NSC 23766 (hydrochloride)

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NSC 23766 (hydrochloride)

Product Name: NSC 23766 (hydrochloride)
CAS No.: 1177865-17-6
Chemical Name: NSC 23766 (hydrochloride)
Synonyms: NSC-23766 HCl;Rac1 Inhibitor;NSC-23766 3HCl;NSC 23766, >=98%;NSC 23766 (hydrochloride);NSC23766 trihydrochloride;NSC-23766 trihydrochloride;NSC 23766 (trihydrochloride);NSC 23766;NSC23766;NSC-23766;NSC 23766 (hydrochloride) USP/EP/BP
CBNumber: CB32591873
Molecular Formula: C24H35N7
Formula Weight: 421.5816
MOL File: 1177865-17-6.mol

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NSC 23766 (hydrochloride) Property

Melting point:: >225°C (dec.)
storage temp.: -20°C
solubility: H2O: soluble10mg/mL, clear
form: powder
color: white to beige

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 553502
Product name: Rac1 Inhibitor
Packaging: 5mg
Price: $432
Updated: 2024/03/01

Sigma-Aldrich

Product number: 553502
Product name: Rac1 Inhibitor
Packaging: 10mg
Price: $461
Updated: 2024/03/01

Cayman Chemical

Product number: 13196
Product name: NSC 23766 (hydrochloride)
Purity: ≥98%
Packaging: 1mg
Price: $33
Updated: 2024/03/01

Cayman Chemical

Product number: 13196
Product name: NSC 23766 (hydrochloride)
Purity: ≥98%
Packaging: 5mg
Price: $96
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML0952
Product name: NSC23766 trihydrochloride
Purity: ≥97% (HPLC)
Packaging: 5mg
Price: $87.6
Updated: 2024/03/01

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NSC 23766 (hydrochloride) Chemical Properties,Usage,Production

Description

Rac1 is a GTPase that is involved in the regulation of the cell cycle, cell-cell adhesion, motility, and differentiation. Rac1 is activated by its interaction with specific guanine nucleotide exchange factors (GEFs). NSC 23766 is a cell-permeable, reversible inhibitor of Rac1 activation by the Rac-specific GEFs TrioN and Tiam 1 (IC₅₀ = 50 μM). It has no effect on the closely related GTPases, Cdc42 and RhoA. NSC23766 has been used to investigate the role of Rac1 in such diverse cellular functions as stem cell mobilization, epithelial cell migration, angiogenesis, leukemia cell migration and growth, and gene expression.

Uses

NSC23766 trihydrochloride has been used as a ras-related C3 botulinum toxin substrate 1 (RAC1) inhibitor.

Uses

NSC 23766 is a highly soluble and membrane permeable Rac GTPase inhibitor. NSC 23766 inhibits Rac GTPase by targeting Rac activation by guanine nucleotide exchange factor (GEF). NSC 23766 has been shown to inhibit the anchorage-independent growth and invasion phenotypes of human prostate cancer PC-3 cells.

Definition

ChEBI: NSC 23766 trihydrochloride is a hydrochloride resulting from the formal reaction of NSC 23766 with 3 mol eq. of hydrogen chloride. An inhibitor of the signalling G-protein known as RAC1 (Ras-related C3 botulinum toxin substrate 1). It has a role as an EC 3.6.5.2 (small monomeric GTPase) inhibitor, an antiviral agent, an apoptosis inducer and a muscarinic antagonist. It contains a NSC 23766.

Biochem/physiol Actions

NSC23766 is an inhibitor of Rac1, a Rho-family GTPase. The compound blocks activation by the guanine nucleotide exchange factors Trio and Tiam1, but does not affect interactions with RhoA or Cdc42. NSC23766 blocks ADP-mediated platelet aggregation. Inhibition of Rac1 by NSC23766 restores sensitivity to trastuzumab by restoring down-regulation of ErbB2.

storage

Desiccate at RT

References

[1]. gao y, dickerson jb, guo f, zheng j, zheng y. rational design and characterization of a rac gtpase-specific small molecule inhibitor. proc natl acad sci u s a. 2004 may 18;101(20):7618-23.
[2]. baumer y, spindler v, werthmann rc, bünemann m, waschke j. role of rac 1 and camp in endothelial barrier stabilization and thrombin-induced barrier breakdown. j cell physiol. 2009 sep;220(3):716-26.
[3]. jin s1, ray rm, johnson lr. rac1 mediates intestinal epithelial cell apoptosis via jnk. am j physiol gastrointest liver physiol. 2006 dec;291(6):g1137-47.

NSC 23766 (hydrochloride) Preparation Products And Raw materials

Raw materials

Preparation Products

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NSC 23766 (hydrochloride) Suppliers

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1177865-17-6, NSC 23766 (hydrochloride)Related Search:

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NSC 23766; NSC23766;NSC-23766 TRIHYDROCHLORIDE;NSC23766 TRIHYDROCHLORIDE

NSC 23766;NSC23766;NSC-23766

N6-[2-[[4-(Diethylamino)-1-methylbutyl]amino]-6-methyl-4-pyrimidinyl]-2-methyl-4,6-quinolinediamine trihydrochloride

Rac1 Inhibitor - CAS 1177865-17-6 - Calbiochem

NSC 23766 (hydrochloride)

NSC 23766 (trihydrochloride)

NSC23766 trihydrochloride

NSC-23766 trihydrochloride

N6-[2-(4-Diethylamino-1-methyl-butylamino)-6-methyl-pyrimidin-4-yl]-2-methyl-quinoline-4,6-diamine trihydrochloride

NSC-23766 HCl

NSC 23766, >=98%

Rac1 Inhibitor

NSC-23766 3HCl

NSC 23766 (hydrochloride) USP/EP/BP

Inhibitor,Ras,inhibit,Apoptosis,NSC 23766 trihydrochloride

NSC 23766 trihydrochloride, Rac-1 inhibitor

1177865-17-6

Inhibitors

Amines, Aromatics, Inhibitors