NSC 23766 (hydrochloride)
- Product Name
- NSC 23766 (hydrochloride)
- CAS No.
- 1177865-17-6
- Chemical Name
- NSC 23766 (hydrochloride)
- Synonyms
- NSC-23766 HCl;Rac1 Inhibitor;NSC-23766 3HCl;NSC 23766, >=98%;NSC 23766 (hydrochloride);NSC23766 trihydrochloride;NSC-23766 trihydrochloride;NSC 23766 (trihydrochloride);NSC 23766;NSC23766;NSC-23766;NSC 23766 (hydrochloride) USP/EP/BP
- CBNumber
- CB32591873
- Molecular Formula
- C24H35N7
- Formula Weight
- 421.5816
- MOL File
- 1177865-17-6.mol
NSC 23766 (hydrochloride) Property
- Melting point:
- >225°C (dec.)
- storage temp.
- -20°C
- solubility
- H2O: soluble10mg/mL, clear
- form
- powder
- color
- white to beige
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- 553502
- Product name
- Rac1 Inhibitor
- Packaging
- 5mg
- Price
- $432
- Updated
- 2024/03/01
- Product number
- 553502
- Product name
- Rac1 Inhibitor
- Packaging
- 10mg
- Price
- $461
- Updated
- 2024/03/01
- Product number
- 13196
- Product name
- NSC 23766 (hydrochloride)
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $33
- Updated
- 2024/03/01
- Product number
- 13196
- Product name
- NSC 23766 (hydrochloride)
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $96
- Updated
- 2024/03/01
- Product number
- SML0952
- Product name
- NSC23766 trihydrochloride
- Purity
- ≥97% (HPLC)
- Packaging
- 5mg
- Price
- $87.6
- Updated
- 2024/03/01
NSC 23766 (hydrochloride) Chemical Properties,Usage,Production
Description
Rac1 is a GTPase that is involved in the regulation of the cell cycle, cell-
Uses
NSC23766 trihydrochloride has been used as a ras-related C3 botulinum toxin substrate 1 (RAC1) inhibitor.
Uses
NSC 23766 is a highly soluble and membrane permeable Rac GTPase inhibitor. NSC 23766 inhibits Rac GTPase by targeting Rac activation by guanine nucleotide exchange factor (GEF). NSC 23766 has been shown to inhibit the anchorage-independent growth and invasion phenotypes of human prostate cancer PC-3 cells.
Definition
ChEBI: NSC 23766 trihydrochloride is a hydrochloride resulting from the formal reaction of NSC 23766 with 3 mol eq. of hydrogen chloride. An inhibitor of the signalling G-protein known as RAC1 (Ras-related C3 botulinum toxin substrate 1). It has a role as an EC 3.6.5.2 (small monomeric GTPase) inhibitor, an antiviral agent, an apoptosis inducer and a muscarinic antagonist. It contains a NSC 23766.
Biochem/physiol Actions
NSC23766 is an inhibitor of Rac1, a Rho-family GTPase. The compound blocks activation by the guanine nucleotide exchange factors Trio and Tiam1, but does not affect interactions with RhoA or Cdc42. NSC23766 blocks ADP-mediated platelet aggregation. Inhibition of Rac1 by NSC23766 restores sensitivity to trastuzumab by restoring down-regulation of ErbB2.
storage
Desiccate at RT
References
[1]. gao y, dickerson jb, guo f, zheng j, zheng y. rational design and characterization of a rac gtpase-specific small molecule inhibitor. proc natl acad sci u s a. 2004 may 18;101(20):7618-23.
[2]. baumer y, spindler v, werthmann rc, bünemann m, waschke j. role of rac 1 and camp in endothelial barrier stabilization and thrombin-induced barrier breakdown. j cell physiol. 2009 sep;220(3):716-26.
[3]. jin s1, ray rm, johnson lr. rac1 mediates intestinal epithelial cell apoptosis via jnk. am j physiol gastrointest liver physiol. 2006 dec;291(6):g1137-47.
NSC 23766 (hydrochloride) Preparation Products And Raw materials
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