ChemicalBook > CAS DataBase List > PI3-Kinase α Inhibitor 2

PI3-Kinase α Inhibitor 2

Product Name
PI3-Kinase α Inhibitor 2
CAS No.
371943-05-4
Chemical Name
PI3-Kinase α Inhibitor 2
Synonyms
PI3K-IN-18;Compound 15e;PI3-Kinase α Inhibitor 2;Compound 15e, 98.0+ % (HPLC);PI3-Kinase .alpha. Inhibitor 2;PI 3-Kinase Inhibitor 2 B-0304;PI3-Kinase α Inhibitor 2 Exclusive;3-(4-Morpholinothieno[3,2-d]pyrimidin-2-yl)phenol;3-[4-(4-morpholinyl)thieno[3,2-d]pyrimidin-2-yl]Phenol;Phenol, 3-[4-(4-morpholinyl)thieno[3,2-d]pyrimidin-2-yl]-
CBNumber
CB32592007
Molecular Formula
C16H15N3O2S
Formula Weight
313.37
MOL File
371943-05-4.mol
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PI3-Kinase α Inhibitor 2 Property

storage temp. 
Store at -20°C
solubility 
DMF: 30 mg/ml; DMF:PBS(pH 7.2) (1:3): 0.25mg/ml; DMSO: 25 mg/ml; Ethanol: 1 mg/ml
form 
White to off-white solid.
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
10010177
Product name
PI3-Kinase α Inhibitor 2
Purity
≥98%
Packaging
500μg
Price
$28
Updated
2024/03/01
Cayman Chemical
Product number
10010177
Product name
PI3-Kinase α Inhibitor 2
Purity
≥98%
Packaging
1mg
Price
$50
Updated
2024/03/01
Cayman Chemical
Product number
10010177
Product name
PI3-Kinase α Inhibitor 2
Purity
≥98%
Packaging
5mg
Price
$207
Updated
2024/03/01
Cayman Chemical
Product number
10010177
Product name
PI3-Kinase α Inhibitor 2
Purity
≥98%
Packaging
10mg
Price
$357
Updated
2024/03/01
AK Scientific
Product number
1688AH
Product name
Compound15E
Packaging
5mg
Price
$326
Updated
2021/12/16
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PI3-Kinase α Inhibitor 2 Chemical Properties,Usage,Production

Description

PI3-Kinase α (PI3Kα) inhibitor 2 is an inhibitor of PI3K p110α (IC50 = 2 nM in an enzyme assay). It is selective for p110α over p110β, p110γ, and PI3K C2β (IC50s = 16, 660, and 220 nM, respectively). It also inhibits mammalian target of rapamycin (mTOR; IC50 = 49 nM). PI3Kα inhibitor 2 inhibits proliferation in A375 melanoma cells with an IC50 value of 0.58 μM.

Uses

PI3K-IN-18 (Compound 1) is a PI3K inhibitor, and can also effectively inhibit the homologous enzymemTOR. The IC50 values of PI3K-IN-18 for mTOR and PI3K-α were 49 nM and 41 nM, respectively[1].

Definition

ChEBI: PI3-Kinase alpha Inhibitor 2 is an organonitrogen heterocyclic compound, an organosulfur heterocyclic compound and an organic heterobicyclic compound.

IC 50

mTOR: 49 nM (IC50); PI3Kα: 41 nM (IC50)

References

[1] Verheijen, Jeroen C et al. “Discovery of 2-arylthieno[3,2-d]pyrimidines containing 8-oxa-3-azabi-cyclo[3.2.1]octane in the 4-position as potent inhibitors of mTOR with selectivity over PI3K.” Bioorganic & medicinal chemistry letters vol. 20,1 (2010): 375-9. DOI:10.1016/j.bmcl.2009.10.075

PI3-Kinase α Inhibitor 2 Preparation Products And Raw materials

Raw materials

Preparation Products

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371943-05-4, PI3-Kinase α Inhibitor 2Related Search:

LY 294002 Hydrochloride 3-METHYLADENINE WORTMANNIN 2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)-

  • PI 3-Kinase Inhibitor 2 B-0304
  • Compound 15e
  • 3-[4-(4-morpholinyl)thieno[3,2-d]pyrimidin-2-yl]Phenol
  • PI3-Kinase α Inhibitor 2
  • Compound 15e, 98.0+ % (HPLC)
  • PI3-Kinase .alpha. Inhibitor 2
  • PI3-Kinase α Inhibitor 2 Exclusive
  • Phenol, 3-[4-(4-morpholinyl)thieno[3,2-d]pyrimidin-2-yl]-
  • PI3 Kinase α Inhibitor 2,PI-3-Kinase α Inhibitor 2,PI3Kinase α Inhibitor 2
  • PI3K-IN-18
  • 3-(4-Morpholinothieno[3,2-d]pyrimidin-2-yl)phenol
  • 371943-05-4