ChemicalBook > CAS DataBase List > N-[2-Methoxy-4-(4-morpholinyl)phenyl]-2-(3-pyridinyl)-4-thiazolecarboxamide

N-[2-Methoxy-4-(4-morpholinyl)phenyl]-2-(3-pyridinyl)-4-thiazolecarboxamide

Product Name
N-[2-Methoxy-4-(4-morpholinyl)phenyl]-2-(3-pyridinyl)-4-thiazolecarboxamide
CAS No.
1042672-97-8
Chemical Name
N-[2-Methoxy-4-(4-morpholinyl)phenyl]-2-(3-pyridinyl)-4-thiazolecarboxamide
Synonyms
CS-647;CS-2482;IRAK-IN-6;IRAK inhibitor 6;N-[2-methoxy-4-(4-morpholinyl)phenyl]-2-(3-pyridinyl)-;N-(2-Methoxy-4-Morpholinophenyl)-2-(pyridin-3-yl)thiazole-4-carboxaMide;N-[2-Methoxy-4-(4-morpholinyl)phenyl]-2-(3-pyridinyl)-4-thiazolecarboxamide;4-ThiazolecarboxaMide, N-[2-Methoxy-4-(4-Morpholinyl)phenyl]-2-(3-pyridinyl)-;Interleukin-1 receptor associated kinase,inhibit,Inhibitor,IL-1R associated kinase,IRAK inhibitor 6,IRAK inhibitor6,IRAK,IRAK inhibitor-6
CBNumber
CB32604265
Molecular Formula
C20H20N4O3S
Formula Weight
396.46
MOL File
1042672-97-8.mol
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N-[2-Methoxy-4-(4-morpholinyl)phenyl]-2-(3-pyridinyl)-4-thiazolecarboxamide Property

Density 
1.335
storage temp. 
Sealed in dry,Store in freezer, under -20°C
solubility 
insoluble in EtOH; insoluble in H2O; ≥9.9 mg/mL in DMSO
form 
solid
pka
10.19±0.70(Predicted)
color 
Light brown to brown
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
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N-Bromosuccinimide Price

ApexBio Technology
Product number
A3504
Product name
IRAKinhibitor6
Packaging
10mM(in 1mL DMSO)
Price
$266
Updated
2021/12/16
ChemScene
Product number
CS-0602
Product name
IRAKinhibitor6
Purity
99.75%
Packaging
10mg
Price
$396
Updated
2021/12/16
ChemScene
Product number
CS-0602
Product name
IRAKinhibitor6
Purity
99.75%
Packaging
5mg
Price
$290
Updated
2021/12/16
ChemScene
Product number
CS-0602
Product name
IRAKinhibitor6
Purity
99.75%
Packaging
50mg
Price
$1030
Updated
2021/12/16
Crysdot
Product number
CD31004734
Product name
IRAKinhibitor6
Purity
98+%
Packaging
10mg
Price
$349
Updated
2021/12/16
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N-[2-Methoxy-4-(4-morpholinyl)phenyl]-2-(3-pyridinyl)-4-thiazolecarboxamide Chemical Properties,Usage,Production

Biological Activity

irak inhibitor 6 is an interleukin-1 receptor associated kinase 4 (irak-4) inhibitor.the interleukin-1 receptor associated kinases (iraks) are a family of serine/threonine kinases related with regulating cellular signalling downstream of the il-18, il-1 and various toll-like receptors. irak-4 is reported to be essential for the activation of the intracellular signalling cascades including nfкb and mapk pathways, which are critical for the production of inflammatory cytokines.

in vitro

a quantitative structure–activity relationship (qsar) study of irak inhibitor 6 and its analogs were conducted by using the genetic algorithm and multiple linear regression (ga-mlr) method [1]. in vitro study showed that compared with its unsubstituted phenyl amide analog, the ortho-substitution with chloro, methoxy and difluoromethoxy analogs of irak inhibitor 6 improved potency against irak-4 significantly. these potency effects were additive, with the most active example in the set being irak inhibitor 6, in which the presence of nitrogen-linked substituents at the para position had a beneficial effect on the rate of turnover by human microsomes (20 μl/min/mg protein) [2].

IC 50

0.16 μm for irak-4

References

[1] pourbasheer e, riahi s, ganjali mr, norouzi p. quantitative structure-activity relationship (qsar) study of interleukin-1 receptor associated kinase 4 (irak-4) inhibitor activity by the genetic algorithm and multiple linear regression (ga-mlr) method. j enzyme inhib med chem. 2010 dec;25(6):844-53.
[2] buckley gm, gowers l, higueruelo ap, jenkins k, mack sr, morgan t, parry dm, pitt wr, rausch o, richard md, sabin v, fraser jl. irak-4 inhibitors. part 1: a series of amides. bioorg med chem lett. 2008 jun 1;18(11):3211-4.

N-[2-Methoxy-4-(4-morpholinyl)phenyl]-2-(3-pyridinyl)-4-thiazolecarboxamide Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from N-[2-Methoxy-4-(4-morpholinyl)phenyl]-2-(3-pyridinyl)-4-thiazolecarboxamide manufacturers

Career Henan Chemical Co
Product
N-[2-Methoxy-4-(4-morpholinyl)phenyl]-2-(3-pyridinyl)-4-thiazolecarboxamide 1042672-97-8
Price
US $1.00/g
Min. Order
1g
Purity
99%
Supply Ability
200kg
Release date
2019-12-26

1042672-97-8, N-[2-Methoxy-4-(4-morpholinyl)phenyl]-2-(3-pyridinyl)-4-thiazolecarboxamideRelated Search:

N-[2-oxo-2-(1,2,3,4-tetrahydronaphthalen-1-ylamino)ethyl]biphenyl-4-carboxamide N-Methoxyphthalimide 6-Imidazo[1,2-a]pyridin-3-yl-N-4-piperidinyl-2-pyridinamine IRAK-1/4 INHIBITOR I 4-[[[3-(3,4-Dimethoxyphenyl)imidazo[1,2-b]pyridazin-6-yl]amino]methyl]benzenesulfonamide 4-[6-[[(Furan-2-yl)methyl]amino]imidazo[1,2-b]pyridazin-3-yl]phenol

  • N-(2-Methoxy-4-Morpholinophenyl)-2-(pyridin-3-yl)thiazole-4-carboxaMide
  • 4-ThiazolecarboxaMide, N-[2-Methoxy-4-(4-Morpholinyl)phenyl]-2-(3-pyridinyl)-
  • N-[2-Methoxy-4-(4-morpholinyl)phenyl]-2-(3-pyridinyl)-4-thiazolecarboxamide
  • IRAK inhibitor 6
  • N-[2-methoxy-4-(4-morpholinyl)phenyl]-2-(3-pyridinyl)-
  • CS-2482
  • CS-647
  • IRAK-IN-6
  • Interleukin-1 receptor associated kinase,inhibit,Inhibitor,IL-1R associated kinase,IRAK inhibitor 6,IRAK inhibitor6,IRAK,IRAK inhibitor-6
  • 1042672-97-8