IRAK-1/4 INHIBITOR I
- Product Name
- IRAK-1/4 INHIBITOR I
- CAS No.
- 509093-47-4
- Chemical Name
- IRAK-1/4 INHIBITOR I
- Synonyms
- CS-1991;IRAK-1/4 Inhibitor;IRAK-1/4 INHIBITOR I;IIRAK-1-4 Inhibitor I;Interleukin-1 Receptor-Associated-Kinase-1/4 Inhibitor;N-(2-Morpholinylethyl)-2-(3-nitrobenzoylamido)-benzimidazole;1-(2-(4-Morpholinyl)ethyl)-2-(3-nitrobenzoylamino)benzimidazole;N-[1-(2-morpholin-4-ylethyl)benzimidazol-2-yl]-3-nitrobenzamide;InSolution? Interleukin-1 Receptor-Associated-Kinase-1/4 Inhibitor;3-Nitro-N-(1-(2-morpholin-4-ylethyl)-1H-benzimidazol-2-yl)benzamide
- CBNumber
- CB7972737
- Molecular Formula
- C20H21N5O4
- Formula Weight
- 395.41
- MOL File
- 509093-47-4.mol
IRAK-1/4 INHIBITOR I Property
- Density
- 1.40
- storage temp.
- 2-8°C
- solubility
- DMSO: ≥5mg/mL
- form
- Yellow crystalline solid
- pka
- 11.54±0.43(Predicted)
- color
- off-white to light yellow
Safety
- Hazard Codes
- T
- Risk Statements
- 25-36/37/38
- Safety Statements
- 26-36/37-45
- RIDADR
- UN 2811 6.1/PG 3
- WGK Germany
- 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 407602
- Product name
- InSolution? Interleukin-1 Receptor-Associated-Kinase-1/4 Inhibitor
- Packaging
- 5mg
- Price
- $172
- Updated
- 2024/03/01
- Product number
- 407601
- Product name
- Interleukin-1 Receptor-Associated-Kinase-1/4 Inhibitor
- Packaging
- 5mg
- Price
- $159
- Updated
- 2024/03/01
- Product number
- 17540
- Product name
- IRAK-1/4 Inhibitor
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 17540
- Product name
- IRAK-1/4 Inhibitor
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $109
- Updated
- 2024/03/01
- Product number
- I5409
- Product name
- IRAK-1/4 Inhibitor I
- Purity
- ≥98% (HPLC), solid
- Packaging
- 5mg
- Price
- $193
- Updated
- 2024/03/01
IRAK-1/4 INHIBITOR I Chemical Properties,Usage,Production
Uses
IRAK-1/4 Inhibitor (interleukin-1 receptor-associated kinases) are important mediators in signal transduction of TIR family members. This regulation protects against the development of cancers and other diseases.
Uses
IRAK-1/4 inhibitor I has been used in various studies to inhibit IRAK1 in hepatoma cell lines and head and neck squamous cell carcinoma (HNSCC) cell lines.
Biological Activity
irak-1-4 inhibitor i is an inhibitor of both irak-1 and irak-4 with ic50 values of 0.3μm and 0.2μm , respectively [1].il-1 receptor-associated kinases play important roles in signal transduction. there are totally four members of the iraks, they are irak-1, irak-2, irak-m and irak-4. irak-4 can activate nf-κb and mapk pathways and it is shown that the inhibition of irak-4 can be an anti-inflammatory therapy. irak-1-4 inhibitor i is an analog of an initial irak-4 inhibitor hit, which is screened out from a small molecule li brary against irak-4. with the less basic n-ethylenemorpholine moiety, irak-1-4 inhibitor i has a higher potency than other analogs. additionally, it does not show any cytotoxicity in a 72 h proliferation assay in hela cells(ed50 >30μm) [1].
Biochem/physiol Actions
IRAK1 overexpression leads to the development of head and neck squamous cell carcinoma (HNSCC). Therefore, IRAK-1/4 inhibitor I might be a potential therapeutic for HNSCC tumors. Various experimental studies states that IRAK-1/4 inhibitor might have a potential to exhibit?inhibitory effects on the nuclear factor (NF)-κB signaling pathway.
storage
Store at -20°C
References
[1] jay p. powers, shyun li, juan c. jaen, jinqian liu, nigel p. c. walker, zhulun wang and holger wesche. discovery and initial sar of inhibitors of interleukin-1 receptor-associated kinase-4. bioorganic & medicinal chemistry letters. 2006, 16: 2842–2845.
IRAK-1/4 INHIBITOR I Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from IRAK-1/4 INHIBITOR I manufacturers
- Product
- IRAK-1/4 INHIBITOR I 509093-47-4
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2019-12-25