N-[2-Methoxy-4-(4-morpholinyl)phenyl]-2-(3-pyridinyl)-4-thiazolecarboxamide
- Product Name
- N-[2-Methoxy-4-(4-morpholinyl)phenyl]-2-(3-pyridinyl)-4-thiazolecarboxamide
- CAS No.
- 1042672-97-8
- Chemical Name
- N-[2-Methoxy-4-(4-morpholinyl)phenyl]-2-(3-pyridinyl)-4-thiazolecarboxamide
- Synonyms
- CS-647;CS-2482;IRAK-IN-6;IRAK inhibitor 6;N-[2-methoxy-4-(4-morpholinyl)phenyl]-2-(3-pyridinyl)-;N-(2-Methoxy-4-Morpholinophenyl)-2-(pyridin-3-yl)thiazole-4-carboxaMide;N-[2-Methoxy-4-(4-morpholinyl)phenyl]-2-(3-pyridinyl)-4-thiazolecarboxamide;4-ThiazolecarboxaMide, N-[2-Methoxy-4-(4-Morpholinyl)phenyl]-2-(3-pyridinyl)-;Interleukin-1 receptor associated kinase,inhibit,Inhibitor,IL-1R associated kinase,IRAK inhibitor 6,IRAK inhibitor6,IRAK,IRAK inhibitor-6
- CBNumber
- CB32604265
- Molecular Formula
- C20H20N4O3S
- Formula Weight
- 396.46
- MOL File
- 1042672-97-8.mol
N-[2-Methoxy-4-(4-morpholinyl)phenyl]-2-(3-pyridinyl)-4-thiazolecarboxamide Property
- Density
- 1.335
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- solubility
- insoluble in EtOH; insoluble in H2O; ≥9.9 mg/mL in DMSO
- form
- solid
- pka
- 10.19±0.70(Predicted)
- color
- Light brown to brown
N-Bromosuccinimide Price
- Product number
- A3504
- Product name
- IRAKinhibitor6
- Packaging
- 10mM(in 1mL DMSO)
- Price
- $266
- Updated
- 2021/12/16
- Product number
- CS-0602
- Product name
- IRAKinhibitor6
- Purity
- 99.75%
- Packaging
- 10mg
- Price
- $396
- Updated
- 2021/12/16
- Product number
- CS-0602
- Product name
- IRAKinhibitor6
- Purity
- 99.75%
- Packaging
- 5mg
- Price
- $290
- Updated
- 2021/12/16
- Product number
- CS-0602
- Product name
- IRAKinhibitor6
- Purity
- 99.75%
- Packaging
- 50mg
- Price
- $1030
- Updated
- 2021/12/16
- Product number
- CD31004734
- Product name
- IRAKinhibitor6
- Purity
- 98+%
- Packaging
- 10mg
- Price
- $349
- Updated
- 2021/12/16
N-[2-Methoxy-4-(4-morpholinyl)phenyl]-2-(3-pyridinyl)-4-thiazolecarboxamide Chemical Properties,Usage,Production
Biological Activity
irak inhibitor 6 is an interleukin-1 receptor associated kinase 4 (irak-4) inhibitor.the interleukin-1 receptor associated kinases (iraks) are a family of serine/threonine kinases related with regulating cellular signalling downstream of the il-18, il-1 and various toll-like receptors. irak-4 is reported to be essential for the activation of the intracellular signalling cascades including nfкb and mapk pathways, which are critical for the production of inflammatory cytokines.
in vitro
a quantitative structure–activity relationship (qsar) study of irak inhibitor 6 and its analogs were conducted by using the genetic algorithm and multiple linear regression (ga-mlr) method [1]. in vitro study showed that compared with its unsubstituted phenyl amide analog, the ortho-substitution with chloro, methoxy and difluoromethoxy analogs of irak inhibitor 6 improved potency against irak-4 significantly. these potency effects were additive, with the most active example in the set being irak inhibitor 6, in which the presence of nitrogen-linked substituents at the para position had a beneficial effect on the rate of turnover by human microsomes (20 μl/min/mg protein) [2].
IC 50
0.16 μm for irak-4
References
[1] pourbasheer e, riahi s, ganjali mr, norouzi p. quantitative structure-activity relationship (qsar) study of interleukin-1 receptor associated kinase 4 (irak-4) inhibitor activity by the genetic algorithm and multiple linear regression (ga-mlr) method. j enzyme inhib med chem. 2010 dec;25(6):844-53.
[2] buckley gm, gowers l, higueruelo ap, jenkins k, mack sr, morgan t, parry dm, pitt wr, rausch o, richard md, sabin v, fraser jl. irak-4 inhibitors. part 1: a series of amides. bioorg med chem lett. 2008 jun 1;18(11):3211-4.
N-[2-Methoxy-4-(4-morpholinyl)phenyl]-2-(3-pyridinyl)-4-thiazolecarboxamide Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from N-[2-Methoxy-4-(4-morpholinyl)phenyl]-2-(3-pyridinyl)-4-thiazolecarboxamide manufacturers
- Product
- N-[2-Methoxy-4-(4-morpholinyl)phenyl]-2-(3-pyridinyl)-4-thiazolecarboxamide 1042672-97-8
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2019-12-26