6-Imidazo[1,2-a]pyridin-3-yl-N-4-piperidinyl-2-pyridinamine
- Product Name
- 6-Imidazo[1,2-a]pyridin-3-yl-N-4-piperidinyl-2-pyridinamine
- CAS No.
- 1042224-63-4
- Chemical Name
- 6-Imidazo[1,2-a]pyridin-3-yl-N-4-piperidinyl-2-pyridinamine
- Synonyms
- 6-imidazo[1;IRAK inhibitor;IRAK inhibitor 1;Cyclopamine inhibitor 1;IRAK inhibitor 1, 10 mM in DMSO;2-a]pyridin-3-yl-N-4-piperidinyl-;6-Imidazo[1,2-a]pyridin-3-yl-N-4-piperidinyl-2-pyridinamine;2-PyridinaMine, 6-iMidazo[1,2-a]pyridin-3-yl-N-4-piperidinyl-;6-(Imidazo[1,2-a]pyridin-3-yl)-N-(piperidin-4-yl)pyridin-2-amine;IRAK inhibitor 1,Inhibitor,inhibit,Interleukin-1 receptor associated kinase,IL-1R associated kinase,IRAK inhibitor1,IRAK inhibitor-1,IRAK
- CBNumber
- CB82604194
- Molecular Formula
- C17H19N5
- Formula Weight
- 293.37
- MOL File
- 1042224-63-4.mol
6-Imidazo[1,2-a]pyridin-3-yl-N-4-piperidinyl-2-pyridinamine Property
- Density
- 1.32
- storage temp.
- Store at -20°C
- solubility
- insoluble in EtOH; insoluble in H2O; ≥14.4 mg/mL in DMSO
- form
- Powder
- pka
- 9.94±0.10(Predicted)
- color
- Light yellow to yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H311Toxic in contact with skin
H331Toxic if inhaled
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P310Immediately call a POISON CENTER or doctor/physician.
P330Rinse mouth.
P361Remove/Take off immediately all contaminated clothing.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- A3500
- Product name
- IRAKinhibitor1
- Packaging
- 5mg
- Price
- $225
- Updated
- 2021/12/16
- Product number
- CS-0603
- Product name
- IRAKinhibitor1
- Purity
- >99.0%
- Packaging
- 5mg
- Price
- $290
- Updated
- 2021/12/16
- Product number
- A3500
- Product name
- IRAKinhibitor1
- Packaging
- 10mg
- Price
- $307
- Updated
- 2021/12/16
- Product number
- A3500
- Product name
- IRAKinhibitor1
- Packaging
- 50mg
- Price
- $378
- Updated
- 2021/12/16
- Product number
- CS-0603
- Product name
- IRAKinhibitor1
- Purity
- >99.0%
- Packaging
- 10mg
- Price
- $396
- Updated
- 2021/12/16
6-Imidazo[1,2-a]pyridin-3-yl-N-4-piperidinyl-2-pyridinamine Chemical Properties,Usage,Production
Uses
IRAK inhibitor 1 is a potent IRAK-4 inhibitor with IC50 of 216 nM, is poorly active against JNK-1 and JNK-2 with IC50 of 3.801 μM, and >10 μM, respectively.
Biological Activity
the interleukin-1 receptor associated kinase (irak) family is comprised of four family members irak-1, irak-2, irak-3/m, and irak-4. upon activation of their upstream cognate receptors, irak-4 is thought to phosphorylate irak-1 resulting in the activation and autophosphorylation of irak-1 an subsequent phosphorylation of downstream substrates. irak inhibitor 1 is an inhibitor of interleukin-1 receptor associated kinase 4 (irak-4).
in vitro
the regioisomeric pyridines irak inhibitor 1 (6) and it analogue (7) showed contrasting sar, with the 2,6-pyridine isomer irak inhibitor 1 having low-nanomolar potency whilst the 2,4-pyridine isomer 7 showed little activity, despite having a more accessible bidentate-binding motif. at 10 μm, irak inhibitor 1 was found to have 39% inhibition for jnk-1 and 15% inhibition for jnk-2, respectivley [1].
target
IRAK-4
IC 50
35 nm for irak-4
References
[1] buckley gm, ceska ta, fraser jl, gowers l, groom cr, higueruelo ap, jenkins k, mack sr, morgan t, parry dm, pitt wr, rausch o, richard md, sabin v. irak-4 inhibitors. part ii: a structure-based assessment of imidazo[1,2-a]pyridine binding. bioorg med chem lett. 2008;18(11):3291-5.
6-Imidazo[1,2-a]pyridin-3-yl-N-4-piperidinyl-2-pyridinamine Preparation Products And Raw materials
Raw materials
Preparation Products
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