6-Imidazo[1,2-a]pyridin-3-yl-N-4-piperidinyl-2-pyridinamine

ChemicalBook > CAS DataBase List > 6-Imidazo[1,2-a]pyridin-3-yl-N-4-piperidinyl-2-pyridinamine

6-Imidazo[1,2-a]pyridin-3-yl-N-4-piperidinyl-2-pyridinamine

Product Name: 6-Imidazo[1,2-a]pyridin-3-yl-N-4-piperidinyl-2-pyridinamine
CAS No.: 1042224-63-4
Chemical Name: 6-Imidazo[1,2-a]pyridin-3-yl-N-4-piperidinyl-2-pyridinamine
Synonyms: 6-imidazo[1;IRAK inhibitor;IRAK inhibitor 1;Cyclopamine inhibitor 1;2-a]pyridin-3-yl-N-4-piperidinyl-;6-Imidazo[1,2-a]pyridin-3-yl-N-4-piperidinyl-2-pyridinamine;2-PyridinaMine, 6-iMidazo[1,2-a]pyridin-3-yl-N-4-piperidinyl-;6-(Imidazo[1,2-a]pyridin-3-yl)-N-(piperidin-4-yl)pyridin-2-amine;IRAK inhibitor 1,Inhibitor,inhibit,Interleukin-1 receptor associated kinase,IL-1R associated kinase,IRAK inhibitor1,IRAK inhibitor-1,IRAK
CBNumber: CB82604194
Molecular Formula: C17H19N5
Formula Weight: 293.37
MOL File: 1042224-63-4.mol

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6-Imidazo[1,2-a]pyridin-3-yl-N-4-piperidinyl-2-pyridinamine Property

Density: 1.32
storage temp.: Store at -20°C
solubility: insoluble in EtOH; insoluble in H2O; ≥14.4 mg/mL in DMSO
form: Powder
pka: 9.94±0.10(Predicted)
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ApexBio Technology

Product number: A3500
Product name: IRAKinhibitor1
Packaging: 5mg
Price: $225
Updated: 2021/12/16

ChemScene

Product number: CS-0603
Product name: IRAKinhibitor1
Purity: >99.0%
Packaging: 5mg
Price: $290
Updated: 2021/12/16

ApexBio Technology

Product number: A3500
Product name: IRAKinhibitor1
Packaging: 10mg
Price: $307
Updated: 2021/12/16

ApexBio Technology

Product number: A3500
Product name: IRAKinhibitor1
Packaging: 50mg
Price: $378
Updated: 2021/12/16

ChemScene

Product number: CS-0603
Product name: IRAKinhibitor1
Purity: >99.0%
Packaging: 10mg
Price: $396
Updated: 2021/12/16

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6-Imidazo[1,2-a]pyridin-3-yl-N-4-piperidinyl-2-pyridinamine Chemical Properties,Usage,Production

Biological Activity

the interleukin-1 receptor associated kinase (irak) family is comprised of four family members irak-1, irak-2, irak-3/m, and irak-4. upon activation of their upstream cognate receptors, irak-4 is thought to phosphorylate irak-1 resulting in the activation and autophosphorylation of irak-1 an subsequent phosphorylation of downstream substrates. irak inhibitor 1 is an inhibitor of interleukin-1 receptor associated kinase 4 (irak-4).

in vitro

the regioisomeric pyridines irak inhibitor 1 (6) and it analogue (7) showed contrasting sar, with the 2,6-pyridine isomer irak inhibitor 1 having low-nanomolar potency whilst the 2,4-pyridine isomer 7 showed little activity, despite having a more accessible bidentate-binding motif. at 10 μm, irak inhibitor 1 was found to have 39% inhibition for jnk-1 and 15% inhibition for jnk-2, respectivley [1].

target

IRAK-4

IC 50

35 nm for irak-4

References

[1] buckley gm, ceska ta, fraser jl, gowers l, groom cr, higueruelo ap, jenkins k, mack sr, morgan t, parry dm, pitt wr, rausch o, richard md, sabin v. irak-4 inhibitors. part ii: a structure-based assessment of imidazo[1,2-a]pyridine binding. bioorg med chem lett. 2008;18(11):3291-5.

6-Imidazo[1,2-a]pyridin-3-yl-N-4-piperidinyl-2-pyridinamine Preparation Products And Raw materials

Raw materials

Preparation Products

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1042224-63-4, 6-Imidazo[1,2-a]pyridin-3-yl-N-4-piperidinyl-2-pyridinamineRelated Search:

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6-Imidazo[1,2-a]pyridin-3-yl-N-4-piperidinyl-2-pyridinamine

Cyclopamine inhibitor 1

IRAK inhibitor 1

2-PyridinaMine, 6-iMidazo[1,2-a]pyridin-3-yl-N-4-piperidinyl-

2-a]pyridin-3-yl-N-4-piperidinyl-

6-imidazo[1

IRAK inhibitor

IRAK inhibitor 1,Inhibitor,inhibit,Interleukin-1 receptor associated kinase,IL-1R associated kinase,IRAK inhibitor1,IRAK inhibitor-1,IRAK

6-(Imidazo[1,2-a]pyridin-3-yl)-N-(piperidin-4-yl)pyridin-2-amine

1042224-63-4