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Glucocorticoid receptor agonist

Product Name
Glucocorticoid receptor agonist
CAS No.
1245526-82-2
Chemical Name
Glucocorticoid receptor agonist
Synonyms
Glucocorticoid receptor agonist;1H-Pyrrolo[2,3-c]pyridine-2-ethanol, α-[2-(5-fluoro-2-hydroxyphenyl)-2-Methylpropyl]-α-(trifluoroMethyl)-, (αR)-;alpha-[2-(5-Fluoro-2-hydroxyphenyl)-2-methylpropyl]-alpha-(trifluoromethyl)-(alphaR)-1H-pyrrolo[2,3-c]pyridine-2-ethanol;(ALPHAR)-ALPHA-[2-(5-FLUORO-2-HYDROXYPHENYL)-2-METHYLPROPYL]-ALPHA-(TRIFLUOROMETHYL)-1H-PYRROLO[2,3-C]PYRIDINE-2-ETHANOL
CBNumber
CB32624175
Molecular Formula
C20H20F4N2O2
Formula Weight
396.38
MOL File
1245526-82-2.mol
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Glucocorticoid receptor agonist Property

Boiling point:
563.1±50.0 °C(Predicted)
Density 
1.373
storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
pka
10.16±0.43(Predicted)
form 
Powder
color 
White to yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0520
Product name
Glucocorticoidreceptoragonist
Purity
99.56%
Packaging
5mg
Price
$383
Updated
2021/12/16
ApexBio Technology
Product number
A3438
Product name
Glucocorticoidreceptoragonist
Packaging
5mg
Price
$467
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CCH0012915
Product name
(ALPHAR)-ALPHA-[2-(5-FLUORO-2-HYDROXYPHENYL)-2-METHYLPROPYL]-ALPHA-(TRIFLUOROMETHYL)-1H-PYRROLO-[2,3-C]PYRIDINE-2-ETHANOL
Purity
95.00%
Packaging
5MG
Price
$611.6
Updated
2021/12/16
ChemScene
Product number
CS-0520
Product name
Glucocorticoidreceptoragonist
Purity
99.56%
Packaging
10mg
Price
$726
Updated
2021/12/16
ApexBio Technology
Product number
A3438
Product name
Glucocorticoidreceptoragonist
Packaging
10mg
Price
$886
Updated
2021/12/16
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Glucocorticoid receptor agonist Chemical Properties,Usage,Production

Uses

Glucocorticoid receptor agonist is a Glucocorticoid receptor agonist that acts on Glucocorticoid receptor (GR), progesterone receptor (PR) and mineralocorticoid receptor (MR) with the IC50 values of 2.1 , 1200 and 210 nM, respectively. Glucocorticoid receptor agonist has steroid-like anti-inflammatory properties and may be used to improve metabolism and reduce increased levels of body fat and serum insulin[1].

in vivo

Glucocorticoid receptor agonist ((R)-16) exhibits good pharmacokinetic properties in Sprague-Dawley rats[1].
Glucocorticoid receptor agonist ((R)-16) (30 and 10 mg/kg, p.o., daily, 5 weeks) can reduce the increased levels of body fat and serum insulin and shows an effective inhibition of TNF-α production in LPS-stimulated mouse model[1].
The pharmacokinetic parameters of Glucocorticoid receptor agonist ((R)-16) in Sprague-Dawley rat (5 mg/kg i.v. or 30 mg/kg p.o.)[1].

ParametersCl (i.v.)(mL/min/kg)VSS(iv) (L/kg)T1/2(iv)(h)Cmax(po) (ng/mL)AUCinf(po) (h·ng/mL)F(po)%
(R)-16497.61.85509487948

References

[1] Doris Riether, et al. Nonsteroidal dissociated glucocorticoid agonists containing azaindoles as steroid A-ring mimetics. J Med Chem. 2010 Sep 23;53(18):6681-98. DOI:10.1021/jm100751q

Glucocorticoid receptor agonist Preparation Products And Raw materials

Raw materials

Preparation Products

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1245526-82-2, Glucocorticoid receptor agonistRelated Search:

2'-Hydroxyacetophenone Dihydrocaffeic acid Dihydroxybenzoic acid Loteprednol Loteprednol etabonate GR (Glucocorticoid receptor)

  • 1H-Pyrrolo[2,3-c]pyridine-2-ethanol, α-[2-(5-fluoro-2-hydroxyphenyl)-2-Methylpropyl]-α-(trifluoroMethyl)-, (αR)-
  • (ALPHAR)-ALPHA-[2-(5-FLUORO-2-HYDROXYPHENYL)-2-METHYLPROPYL]-ALPHA-(TRIFLUOROMETHYL)-1H-PYRROLO[2,3-C]PYRIDINE-2-ETHANOL
  • Glucocorticoid receptor agonist
  • alpha-[2-(5-Fluoro-2-hydroxyphenyl)-2-methylpropyl]-alpha-(trifluoromethyl)-(alphaR)-1H-pyrrolo[2,3-c]pyridine-2-ethanol
  • 1245526-82-2