RDEA 594

Product Name: RDEA 594
CAS No.: 878672-00-5
Chemical Name: RDEA 594
Synonyms: Lesinurad;Resinad;RDEA 594;Lesinurd;Recinard;Reginald;Resinard;Lesinuras;Lesurinad;Lessinurad
CBNumber: CB32628032
Molecular Formula: C17H14BrN3O2S
Formula Weight: 404.28
MOL File: 878672-00-5.mol

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RDEA 594 Property

Melting point:: >171oC (dec.)
Boiling point:: 643.7±65.0 °C(Predicted)
Density: 1.72±0.1 g/cm3(Predicted)
storage temp.: -20°C Freezer, Under inert atmosphere
solubility: DMSO (Slightly), Methanol (Slightly, Heated)
pka: 2.91±0.10(Predicted)
form: Solid
color: White to Off-White

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 23688
Product name: Lesinurad
Purity: ≥98%
Packaging: 5mg
Price: $57
Updated: 2024/03/01

Cayman Chemical

Product number: 23688
Product name: Lesinurad
Purity: ≥98%
Packaging: 10mg
Price: $95
Updated: 2024/03/01

Cayman Chemical

Product number: 23688
Product name: Lesinurad
Purity: ≥98%
Packaging: 25mg
Price: $208
Updated: 2024/03/01

Cayman Chemical

Product number: 23688
Product name: Lesinurad
Purity: ≥98%
Packaging: 50mg
Price: $356
Updated: 2024/03/01

TRC

Product number: L329700
Product name: Lesinurad
Packaging: 100mg
Price: $130
Updated: 2021/12/16

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RDEA 594 Chemical Properties,Usage,Production

Description

Approved by the FDA late in 2015, lesinurad is an urate anion exchange transporter 1 (URAT1) inhibitor for use in the treatment of gout. Ardea Biosciences, which is a subsidiary of AstraZeneca, developed lesinurad to be used in a combination therapy with xanthine oxidase inhibitors for the treatment of hyperuricaemia associated with gout. The approval process is ongoing in several other countries across the globe, with the EMA Committee for Medicinal Products for Human Use giving lesinurad a positive opinion for use as an adjunctive therapy in combination with xanthine oxidase inhibitors to treat hyperuricaemia.

Uses

Lesinurad is used to synthesize febuxostat which is a non-purine analog inhibitor of xanthine oxidase. Febuxostat is approved by the European Medicines Agency and the US Food and Drug Administration for treating gout.

Definition

ChEBI: A member of the class of triazoles that is [(3-bromo-1,2,4-triazol-5-yl)sulfanyl]acetic acid substituted at position 1 of the triazole ring by a 4-cyclopropylnaphthalen-1-yl group. Used for treatment of gout.

Synthesis

The synthesis of lesinurad began with commercial 1- bromonaphthalene (138). A Kumada coupling between this bromide and cyclopropyl Grignard delivered 139, which after selective nitration to give 140, delivered the oxylate salt 141 (which now is commercially available). Treatment of 141 with KOH followed by thiophosgene at 5 ??C delivered isothiocyanate 142 in 63% yield. Reaction of 142 with formyl hydrazine followed by addition of potassium bicarbonate and mild heating resulted in thio-1,2,4-triazole 144 by the intermediacy of 143. Quantitative alkylation of triazolothiol 144 resulted in |á-mercaptan 145, and this was followed by NBS bromination to afford bromotriazole 146. Ester saponification followed by acidification secured lesinurad (XVII) in a good yield over the final three steps.

RDEA 594 Preparation Products And Raw materials

Raw materials

Preparation Products

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RDEA 594 Suppliers

China 270 India 5 United Kingdom 2 United States 16 Global 293

MedChemexpress LLC

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ApexBio Technology

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Cayman Chemical Company

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AK Scientific, Inc.

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View Lastest Price from RDEA 594 manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Lesinurad 878672-00-5
Price: US $0.00/Kg/Bag
Min. Order: 1KG
Purity: 99%min HPLC
Supply Ability: 1000G
Release date: 2021-08-13

Hebei Chuanghai Biotechnology Co,.LTD

Product: Lesinurad 878672-00-5
Price: US $10.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 10 ton
Release date: 2024-08-20

Henan Aochuang Chemical Co.,Ltd.

Product: Lesinurad 878672-00-5
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-30

878672-00-5, RDEA 594Related Search:

(r)-budesonide DESONIDE MICRONIZED Sasapyrine Cilostazol Rocuronium bromide Flurbiprofen Glucosamine sulfate Valsartan Lesinurad Impurity J Lesinurad Impurity H Lesinurad Impurity 24 Lesinurad Impurity N 1-cyclopropylnaphthalene Lesinurad Impurity 27 Lesinurad Impurity 22 Lesinurad Impurity 4 NAPHTHALENE, 1-CYCLOPROPYL-4-ISOTHIOCYANATO- lesinurad int

Lesinurad impurity1-12

Lesinurd

Lesinurad

RDEA 594

Lesinurad (with 3 ints.)

Lesinurad (RDEA-594)

2-{[5-broMo-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}acetic acid

2-[[5-BroMo-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-yl]thio]acetic acid

Lesurinad

Lesinuras

2-[[5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-1,2,4-triazol-3-yl]sulfanyl]acetic Acid

Lessinurad

RDEA594(Lesinurad )

ethyl 3-(N-(5-chloro-2-nitrophenyl)anilino)-3-oxopropanoate

RDEA 594; RDEA-594; RDEA594

Recinard

Lesinurad（RDEA5)

2-[[5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-1,2,4-triazol-3-yl]sulfanyl]acetic acid Lesinurad

Acetic acid, 2-[[5-bromo-4-(4-cyclopropyl-1-naphthalenyl)-4H-1,2,4-triazol-3-yl]thio]-

Lacy Noulard

RDEA 594 USP/EP/BP

Resinad

2-(5-Bromo-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-ylthio)aceticacid95%

2-(5-chloro-5-methoxyphenyl)aceticacid

Acetic acid, [[5-bromo-4-(4-cyclopropyl-1-naphthalenyl)-4H-1,2,4-triazol-3-yl]thio]-

Lesinurad WRS

Reginald

Lesinurad RDEA594 RDEA-594

Resinard

878672-00-5

Lesinurad (RDEA-594)

API

878672-00-5