RI-1
- Product Name
- RI-1
- CAS No.
- 415713-60-9
- Chemical Name
- RI-1
- Synonyms
- RI-1;CS-909;RI1;RI-1;RI-1, >=98%;RAD51 inhibitor;RAD51 inhibitor 1;RI-1 >=98% (HPLC);RAD51 inhibitor RI-1;recombination,RI 1,homologous,Inhibitor,RAD51,RI-1,inhibit;3-Chloro-1-(3,4-dichlorophenyl)-4-Morpholino-1H-pyrrole-2,5-dione
- CBNumber
- CB32628355
- Molecular Formula
- C14H11Cl3N2O3
- Formula Weight
- 361.61
- MOL File
- 415713-60-9.mol
RI-1 Property
- Boiling point:
- 483.0±45.0 °C(Predicted)
- Density
- 1.61
- storage temp.
- 2-8°C
- solubility
- DMSO: soluble10mg/mL, clear
- pka
- -3.45±0.20(Predicted)
- form
- powder
- color
- yellow to orange
- Stability:
- Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- SML1274
- Product name
- RI-1
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $118
- Updated
- 2024/03/01
- Product number
- SML1274
- Product name
- RI-1
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $462
- Updated
- 2024/03/01
- Product number
- 24182
- Product name
- RI-1
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 24182
- Product name
- RI-1
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $70
- Updated
- 2024/03/01
- Product number
- 24182
- Product name
- RI-1
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $122
- Updated
- 2024/03/01
RI-1 Chemical Properties,Usage,Production
Description
RI-1 (415713-60-9) is a potent and selective inhibitor of RAD51 (IC50 = 5-30 μM), a highly conserved protein that catalyzes DNA repair via homologous recombination.1 It specifically reduces gene conversion in human cells and stimulates single strand annealing. It covalently binds to Cys319 on the surface of RAD51 and disrupts protein-protein interaction. It potentiates the effect of DNA-damaging agents on tumor cells and is a novel tool for studying DNA repair in cells.2 Potentiates the killing of glioblastoma cells by ionizing radiation3 and alkylating drugs4.
Uses
RI 1 is a chemical inhibitor of RAD51, which disrupts homologous recombination in human cells.
Biochem/physiol Actions
RI-1 is a cell-permeable RAD51 inhibitor that binds covalently to the protein surface at Cysteine 319. RI-1 disrupts homologous recombination in human cells.
target
RAD51
References
1) Anand et al. (2017), Rad51-mediated double-strand break repair and mismatch correction of divergent substrates; Nature, 544 377 2) Budke et al. (2012), RI-1: a chemical inhibitor of RAD51 that disrupts homologous recombination in human cells; Nucleic Acids Res., 40 7347 3) Balbous et al. (2016), A radiosensitizing effect of RAD51 inhibition in glioblastoma stem-like cells; BMC Cancer, 16 604 4) Berte et al. (2016), Targeting Homologous Recombination by Pharmacological Inhibitors Enhances the Killing response of Glioblastoma Cells Treated with Alkylating Drugs; Mol. Cancer Ther., 15 2665
RI-1 Preparation Products And Raw materials
Raw materials
Preparation Products
RI-1 Suppliers
- Tel
- --
- Fax
- --
- customerservice@tocris.co.uk
- Country
- United Kingdom
- ProdList
- 5726
- Advantage
- 77
View Lastest Price from RI-1 manufacturers
- Product
- 3-chloro-1-(3,4-dichlorophenyl)-4-morpholin-4-ylpyrrole-2,5-dione 415713-60-9
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- Min98% HPLC
- Supply Ability
- g/kg/ton
- Release date
- 2019-12-23