RI-1

Product Name: RI-1
CAS No.: 415713-60-9
Chemical Name: RI-1
Synonyms: RI-1;CS-909;RI1;RI-1;RI-1, >=98%;RAD51 inhibitor;RAD51 inhibitor 1;RI-1 >=98% (HPLC);RAD51 inhibitor RI-1;recombination,RI 1,homologous,Inhibitor,RAD51,RI-1,inhibit;3-Chloro-1-(3,4-dichlorophenyl)-4-Morpholino-1H-pyrrole-2,5-dione
CBNumber: CB32628355
Molecular Formula: C14H11Cl3N2O3
Formula Weight: 361.61
MOL File: 415713-60-9.mol

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RI-1 Property

Boiling point:: 483.0±45.0 °C(Predicted)
Density: 1.61
storage temp.: 2-8°C
solubility: DMSO: soluble10mg/mL, clear
pka: -3.45±0.20(Predicted)
form: powder
color: yellow to orange
Stability:: Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1274
Product name: RI-1
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $118
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML1274
Product name: RI-1
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $462
Updated: 2024/03/01

Cayman Chemical

Product number: 24182
Product name: RI-1
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 24182
Product name: RI-1
Purity: ≥98%
Packaging: 5mg
Price: $70
Updated: 2024/03/01

Cayman Chemical

Product number: 24182
Product name: RI-1
Purity: ≥98%
Packaging: 10mg
Price: $122
Updated: 2024/03/01

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RI-1 Chemical Properties,Usage,Production

Description

RI-1 (415713-60-9) is a potent and selective inhibitor of RAD51 (IC50 = 5-30 μM), a highly conserved protein that catalyzes DNA repair via homologous recombination.1 It specifically reduces gene conversion in human cells and stimulates single strand annealing. It covalently binds to Cys319 on the surface of RAD51 and disrupts protein-protein interaction. It potentiates the effect of DNA-damaging agents on tumor cells and is a novel tool for studying DNA repair in cells.2 Potentiates the killing of glioblastoma cells by ionizing radiation3 and alkylating drugs4.

Uses

RI 1 is a chemical inhibitor of RAD51, which disrupts homologous recombination in human cells.

Biochem/physiol Actions

RI-1 is a cell-permeable RAD51 inhibitor that binds covalently to the protein surface at Cysteine 319. RI-1 disrupts homologous recombination in human cells.

target

RAD51

References

1) Anand et al. (2017), Rad51-mediated double-strand break repair and mismatch correction of divergent substrates; Nature, 544 377 2) Budke et al. (2012), RI-1: a chemical inhibitor of RAD51 that disrupts homologous recombination in human cells; Nucleic Acids Res., 40 7347 3) Balbous et al. (2016), A radiosensitizing effect of RAD51 inhibition in glioblastoma stem-like cells; BMC Cancer, 16 604 4) Berte et al. (2016), Targeting Homologous Recombination by Pharmacological Inhibitors Enhances the Killing response of Glioblastoma Cells Treated with Alkylating Drugs; Mol. Cancer Ther., 15 2665

RI-1 Preparation Products And Raw materials

Raw materials

Preparation Products

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RI-1 Suppliers

China 80 India 1 United Kingdom 1 United States 17 Global 99

BOC Sciences

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Target molecule Corp.

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Musechem

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TargetMol Chemicals Inc.

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Matrix Scientific

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View Lastest Price from RI-1 manufacturers

Career Henan Chemical Co

Product: 3-chloro-1-(3,4-dichlorophenyl)-4-morpholin-4-ylpyrrole-2,5-dione 415713-60-9
Price: US $1.00/KG
Min. Order: 1KG
Purity: Min98% HPLC
Supply Ability: g/kg/ton
Release date: 2019-12-23

415713-60-9, RI-1Related Search:

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RI-1

3-Chloro-1-(3,4-dichlorophenyl)-4-(4-morpholinyl)-1H-pyrrole-2,5-dione

RI-1, >=98%

RAD51 inhibitor RI-1

RAD51 inhibitor 1

3-Chloro-1-(3,4-dichlorophenyl)-4-Morpholino-1H-pyrrole-2,5-dione

1H-Pyrrole-2,5-dione, 3-chloro-1-(3,4-dichlorophenyl)-4-(4-morpholinyl)-

RI1;RI-1

3-chloro-1-(3,4-dichlorophenyl)-4-morpholin-4-ylpyrrole-2,5-dione

CS-909

3-chloro-1-(3,4-dichlorophenyl)-4-(morpholin-4-yl)-2,5-dihydro-1H-pyrrole-2,5-dione

RAD51 inhibitor

RI-1 >=98% (HPLC)

recombination,RI 1,homologous,Inhibitor,RAD51,RI-1,inhibit

415713-60-9

Inhibitors