BI-97C1

ChemicalBook > CAS DataBase List > BI-97C1

Product Name: BI-97C1
CAS No.: 1228108-65-3
Chemical Name: BI-97C1
Synonyms: BI-97C1;Sabutoclax;BI-97C1 USP/EP/BP;BI-97C1;SABUTOCLAX;Sabutoclax(BI-97Cl);(1R)-1,1',6,6',7,7'-Hexahydroxy-3,3'-dimethyl-N5,N5'-bis((2R)-2-phenylpropyl)-[2,2'-binaphthalene]-5,5'-dicarboxamide;(1R)-1,1',6,6',7,7'-Hexahydroxy-3,3'-dimethyl-N5,N5'-bis[(2R)-2-phenylpropyl]-[2,2'-binaphthalene]-5,5'-dicarboxamide;[2,2'-Binaphthalene]-5,5'-dicarboxamide, 1,1',6,6',7,7'-hexahydroxy-3,3'-dimethyl-N5,N5'-bis[(2R)-2-phenylpropyl]-, (1R)
CBNumber: CB32628375
Molecular Formula: C42H40N2O8
Formula Weight: 700.78
MOL File: 1228108-65-3.mol

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BI-97C1 Property

Melting point:: >130°C (dec.)
Boiling point:: 905.9±65.0 °C(Predicted)
Density: 1.358±0.06 g/cm3(Predicted)
storage temp.: -20°C Freezer
solubility: DMSO (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
form: Solid
pka: 7.35±0.50(Predicted)
color: Light Brown to Brown

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: S080780
Product name: Sabutoclax
Packaging: 5mg
Price: $375
Updated: 2021/12/16

TRC

Product number: S080780
Product name: Sabutoclax
Packaging: 25mg
Price: $1215
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: INB0001265
Product name: SABUTOCLAX
Purity: 95.00%
Packaging: 5MG
Price: $496.99
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 48618
Product name: Sabutoclax
Packaging: 1mg
Price: $625
Updated: 2021/12/16

ApexBio Technology

Product number: A4199
Product name: Sabutoclax
Packaging: 50mg
Price: $675
Updated: 2021/12/16

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BI-97C1 Chemical Properties,Usage,Production

Uses

Sabutoclax(BI-97C1) is a pan-Bcl-2 inhibitor, including Bcl-xL, Bcl-2, Mcl-1 and Bfl-1 with IC50 of 0.31 μM, 0.32 μM, 0.20 μM and 0.62 μM, respectively.

Uses

Sabutoclax is a novel putative MCL-1 inhibitor that induces mitochondrial fragmentation either upstream of or independent of apoptosis.

Biological Activity

sabutoclax is an inhibitor of pan-bcl-2 family with ic50 values of 0.32, 0.31, 0.20 and 0.62 μm for bcl-2, bcl-xl, mcl-1 and bfl-1, respectively [1].sabutoclax is a derivative of apogossypolone. it showed a high binding affinity to bcl-xl both in nmr binding assay and in itc assay, with a kd value of 0.11μm. sabutoclax also showed better cell membrane permeability than other apogossypolone derivatives. in pc3 cells, sabutoclax inhibited cell growth with ec50 value of 0.13 μm. in human bp3 cell line, sabutoclax induced cell apoptosis with ic50 value of 0.049 μm. in mice bearing m2182 cancer xenografts, administration of sabutoclax significantly reduced the tumor size. at dose of 5 mg/kg, sabutoclax induced near complete tumor growth suppression [1].

References

[1] wei j, stebbins j l, kitada s, et al. bi-97c1, an optically pure apogossypol derivative as pan-active inhibitor of antiapoptotic b-cell lymphoma/leukemia-2 (bcl-2) family proteins. journal of medicinal chemistry, 2010, 53(10): 4166-4176.

BI-97C1 Preparation Products And Raw materials

Raw materials

Preparation Products

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1228108-65-3, BI-97C1Related Search:

ABT-199 UMI-77 ABT 737 ABT 263 Obatoclax mesilate Ibrutinib

BI-97C1

Sabutoclax

(1R)-1,1',6,6',7,7'-Hexahydroxy-3,3'-dimethyl-N5,N5'-bis[(2R)-2-phenylpropyl]-[2,2'-binaphthalene]-5,5'-dicarboxamide

[2,2'-Binaphthalene]-5,5'-dicarboxamide, 1,1',6,6',7,7'-hexahydroxy-3,3'-dimethyl-N5,N5'-bis[(2R)-2-phenylpropyl]-, (1R)

BI-97C1;SABUTOCLAX

BI-97C1 USP/EP/BP

Sabutoclax(BI-97Cl)

(1R)-1,1',6,6',7,7'-Hexahydroxy-3,3'-dimethyl-N5,N5'-bis((2R)-2-phenylpropyl)-[2,2'-binaphthalene]-5,5'-dicarboxamide

1228108-65-3

C42H40N2O8

Inhibitors