BI-97C1
- Product Name
- BI-97C1
- CAS No.
- 1228108-65-3
- Chemical Name
- BI-97C1
- Synonyms
- BI-97C1;Sabutoclax;BI-97C1 USP/EP/BP;BI-97C1;SABUTOCLAX;Sabutoclax(BI-97Cl);(1R)-1,1',6,6',7,7'-Hexahydroxy-3,3'-dimethyl-N5,N5'-bis((2R)-2-phenylpropyl)-[2,2'-binaphthalene]-5,5'-dicarboxamide;(1R)-1,1',6,6',7,7'-Hexahydroxy-3,3'-dimethyl-N5,N5'-bis[(2R)-2-phenylpropyl]-[2,2'-binaphthalene]-5,5'-dicarboxamide;[2,2'-Binaphthalene]-5,5'-dicarboxamide, 1,1',6,6',7,7'-hexahydroxy-3,3'-dimethyl-N5,N5'-bis[(2R)-2-phenylpropyl]-, (1R)
- CBNumber
- CB32628375
- Molecular Formula
- C42H40N2O8
- Formula Weight
- 700.78
- MOL File
- 1228108-65-3.mol
BI-97C1 Property
- Melting point:
- >130°C (dec.)
- Boiling point:
- 905.9±65.0 °C(Predicted)
- Density
- 1.358±0.06 g/cm3(Predicted)
- storage temp.
- -20°C Freezer
- solubility
- DMSO (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 7.35±0.50(Predicted)
- color
- Light Brown to Brown
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330Rinse mouth.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- S080780
- Product name
- Sabutoclax
- Packaging
- 5mg
- Price
- $375
- Updated
- 2021/12/16
- Product number
- S080780
- Product name
- Sabutoclax
- Packaging
- 25mg
- Price
- $1215
- Updated
- 2021/12/16
- Product number
- INB0001265
- Product name
- SABUTOCLAX
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $496.99
- Updated
- 2021/12/16
- Product number
- 48618
- Product name
- Sabutoclax
- Packaging
- 1mg
- Price
- $625
- Updated
- 2021/12/16
- Product number
- A4199
- Product name
- Sabutoclax
- Packaging
- 50mg
- Price
- $675
- Updated
- 2021/12/16
BI-97C1 Chemical Properties,Usage,Production
Uses
Sabutoclax(BI-97C1) is a pan-Bcl-2 inhibitor, including Bcl-xL, Bcl-2, Mcl-1 and Bfl-1 with IC50 of 0.31 μM, 0.32 μM, 0.20 μM and 0.62 μM, respectively.
Uses
Sabutoclax is a novel putative MCL-1 inhibitor that induces mitochondrial fragmentation either upstream of or independent of apoptosis.
Biological Activity
sabutoclax is an inhibitor of pan-bcl-2 family with ic50 values of 0.32, 0.31, 0.20 and 0.62 μm for bcl-2, bcl-xl, mcl-1 and bfl-1, respectively [1].sabutoclax is a derivative of apogossypolone. it showed a high binding affinity to bcl-xl both in nmr binding assay and in itc assay, with a kd value of 0.11μm. sabutoclax also showed better cell membrane permeability than other apogossypolone derivatives. in pc3 cells, sabutoclax inhibited cell growth with ec50 value of 0.13 μm. in human bp3 cell line, sabutoclax induced cell apoptosis with ic50 value of 0.049 μm. in mice bearing m2182 cancer xenografts, administration of sabutoclax significantly reduced the tumor size. at dose of 5 mg/kg, sabutoclax induced near complete tumor growth suppression [1].
References
[1] wei j, stebbins j l, kitada s, et al. bi-97c1, an optically pure apogossypol derivative as pan-active inhibitor of antiapoptotic b-cell lymphoma/leukemia-2 (bcl-2) family proteins. journal of medicinal chemistry, 2010, 53(10): 4166-4176.