2-AMINO-4,5-DICHLOROBENZOIC ACID
- Product Name
- 2-AMINO-4,5-DICHLOROBENZOIC ACID
- CAS No.
- 20776-61-8
- Chemical Name
- 2-AMINO-4,5-DICHLOROBENZOIC ACID
- Synonyms
- 3-AMINO-4,5-DICHLOROBENZOIC ACID;4,5-dichloroanthranilic acid;2-aiMo-4,5-dichlorobenzoic acid;4,5-Dichloro-2-aminobenzoicacid;2-AMino-4,5-dichlorobenzolc acid;2-AMINO-4,5-DICHLOROBENZOIC ACID;Benzoic acid, 2-amino-4,5-dichloro-;2-Amino-4,5-dich2-Amino-4,5-dichlorobenzoic Acidlorobenzoic Acid
- CBNumber
- CB3263462
- Molecular Formula
- C7H5Cl2NO2
- Formula Weight
- 206.03
- MOL File
- 20776-61-8.mol
2-AMINO-4,5-DICHLOROBENZOIC ACID Property
- Melting point:
- 213-214℃
- Boiling point:
- 380.5±42.0 °C(Predicted)
- Density
- 1.607±0.06 g/cm3 (20 ºC 760 Torr)
- storage temp.
- 2-8°C, protect from light
- pka
- 4.34±0.10(Predicted)
- Appearance
- Off-white to light yellow Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- A597145
- Product name
- 2-Amino-4,5-dichlorobenzoicAcid
- Packaging
- 50mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- A597145
- Product name
- 2-Amino-4,5-dichlorobenzoicAcid
- Packaging
- 100mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- FA156412
- Product name
- 2-Amino-4,5-dichlorobenzoic acid
- Packaging
- 1g
- Price
- $90
- Updated
- 2021/12/16
- Product number
- FA156412
- Product name
- 2-Amino-4,5-dichlorobenzoic acid
- Packaging
- 2g
- Price
- $140
- Updated
- 2021/12/16
- Product number
- FA156412
- Product name
- 2-Amino-4,5-dichlorobenzoic acid
- Packaging
- 5G
- Price
- $260
- Updated
- 2021/12/16
2-AMINO-4,5-DICHLOROBENZOIC ACID Chemical Properties,Usage,Production
Chemical Properties
slight yellow crystalline powder
Synthesis
15997-89-4
20776-61-8
The general procedure for the synthesis of 2-amino-4,5-dichlorobenzoic acid from 5,6-dichloroisoindoline-1,3-dione was as follows: 25% aqueous sodium hydroxide solution (75 mL) was cooled to 0°C, bromine (16.0 g, 0.1 mol) was added slowly and the mixture was stirred until a yellow NaOBr solution was formed. 4,5-Dichlorophthalimide (21.6 g, 0.1 mol) was dissolved in 5% aqueous sodium hydroxide solution (170 mL), cooled to 0°C, and then the solution was slowly added to the above cold NaOBr solution. The reaction mixture was reacted under vigorous stirring for 5 minutes and subsequently heated to 80°C and held for 2 minutes. After completion of the reaction, the mixture was cooled and neutralized with concentrated hydrochloric acid to pH neutral. The precipitate was collected by filtration and washed with ice water. The crude product was purified by solvent recrystallization from a mixture of methanol and water to give 14.8 g (72% yield) of 2-amino-4,5-dichlorobenzoic acid with a melting point of 196-203° C. The crude product was purified by solvent recrystallization from a mixture of methanol and water.
References
[1] Bioorganic and Medicinal Chemistry Letters, 2007, vol. 17, # 19, p. 5472 - 5478
[2] Patent: US6927214, 2005, B1. Location in patent: Page/Page column 97-98
[3] European Journal of Medicinal Chemistry, 2012, vol. 58, p. 624 - 639
2-AMINO-4,5-DICHLOROBENZOIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-AMINO-4,5-DICHLOROBENZOIC ACID manufacturers
- Product
- 2-AMINO-4,5-DICHLOROBENZOIC ACID 20776-61-8
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2019-07-12