IOX2

Product Name: IOX2
CAS No.: 931398-72-0
Chemical Name: IOX2
Synonyms: IOX2;JICL38;CS-564;IOX 2, >=98%;IOX2(Glycine);IOX-2; IOX2; IOX 2;DesidustatImpurity1;IOX2;IOX 2;IOX-2;JICL38;(1-benzyl-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carbonyl)glycine;2-[(1-BENZYL-4-HYDROXY-2-OXOQUINOLINE-3-CARBONYL)AMINO]ACETIC ACID
CBNumber: CB32638323
Molecular Formula: C19H16N2O5
Formula Weight: 352.34
MOL File: 931398-72-0.mol

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IOX2 Property

Boiling point:: 642.8±55.0 °C(Predicted)
Density: 1.470±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: soluble5mg/mL, clear (warmed)
pka: 3.61±0.10(Predicted)
form: powder
color: white to beige
InChIKey: CAOSCCRYLYQBES-UHFFFAOYSA-N

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Safety

Hazard Codes: T
Risk Statements: 25
Safety Statements: 45
RIDADR: UN 2811 6.1 / PGIII
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Danger
Hazard statements: H301Toxic if swalloed
Precautionary statements: P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0652
Product name: IOX2
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $119
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML0652
Product name: IOX2
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $481
Updated: 2024/03/01

Cayman Chemical

Product number: 11573
Product name: IOX2
Purity: ≥98%
Packaging: 5mg
Price: $68
Updated: 2024/03/01

Cayman Chemical

Product number: 11573
Product name: IOX2
Purity: ≥98%
Packaging: 10mg
Price: $109
Updated: 2024/03/01

Cayman Chemical

Product number: 11573
Product name: IOX2
Purity: ≥98%
Packaging: 25mg
Price: $169
Updated: 2024/03/01

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IOX2 Chemical Properties,Usage,Production

Uses

IOX2 is a potent inhibitor of HIF-1α prolyl hydroxylase-2 (PHD2) with IC50 of 21 nM.

Uses

IOX2 has been used as PHD inhibitor to induce pseudo-hypoxia.

Definition

ChEBI: 2-[[[4-hydroxy-2-oxo-1-(phenylmethyl)-3-quinolinyl]-oxomethyl]amino]acetic acid is a member of quinolines.

Biological Activity

iox2 is a potent and selective inhibitor of hif-1α prolyl hydroxylase-2 (phd2) with an ic50 of 21 nm for phd2/elgn-1 in a cell-free assay, iox2 has shown >100-fold selectivity over jmjd2a, jmjd2c, jmjd2e, jmjd3, or the 2og oxygenase fih [1].phds consist three isoforms, named phd1, phd2 and phd3. phds are dioxygenases that utilize oxygen as co-substrate providing the molecular basis for the oxygen-sensing function of these enzymes. it has been reported that phds are strikingly sensitive to graded levels of hypoxia, mirroring the progressive increases in hif-1α protein and dna binding activity that are observed when cells are exposed to gradual hypoxia [2]. in rcc4 cells, iox2 inhibited hif-1α hydroxylation at 50 μm [1].

Biochem/physiol Actions

IOX2 is selective and potent inhibitor of prolyl hydroxylases (PHD). Stabilization of HIF-1R through inhibition of PHD has been examined as a potential treatment for ischemic diseases including anemia, myocardial infarction, and stroke. IOX2 is a selective inhibitor of the hypoxia inducible factor (HIF) prolyl-hydroxylases (PHD) that exhibits up-regulation of HIF1a in zebrafish. For full characterization details, please visit the IOX2 probe summary on the Structural Genomics Consortium (SGC) website.To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc

storage

Store at +4°C

References

[1] murray j k, balan c, allgeier a m, et al. dipeptidyl-quinolone derivatives inhibit hypoxia inducible factor-1α prolyl hydroxylases-1,-2, and-3 with altered selectivity[j]. journal of combinatorial chemistry, 2010, 12(5): 676-686.
[2] berra e, benizri e, ginouvès a, et al. hif prolyl‐hydroxylase 2 is the key oxygen sensor setting low steady‐state levels of hif‐1α in normoxia[j]. the embo journal, 2003, 22(16): 4082-4090.

IOX2 Preparation Products And Raw materials

Raw materials

Preparation Products

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IOX2 Suppliers

China 101 India 2 United Kingdom 1 United States 22 Global 126

MedChemexpress LLC

Tel: 021-58955995
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ApexBio Technology LLC

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Target molecule Corp.

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Musechem

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TargetMol Chemicals Inc.

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InvivoChem

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Cckinase, Inc.

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BOC Sciences

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Alchem Pharmtech,Inc.

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Aladdin Scientific

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United States Biological

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ApexBio Technology

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Cayman Chemical Company

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United States Biological

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Creative Enzymes

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MedChemExpress

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Axon Medchem LLC

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Matrix Scientific

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LKT Laboratories, Inc.

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View Lastest Price from IOX2 manufacturers

Career Henan Chemical Co

Product: IOX2 931398-72-0
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2019-07-09

Career Henan Chemical Co

Product: E6005 931398-72-0
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2019-07-09

Career Henan Chemical Co

Product: E6005 947620-48-6
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2019-07-09

931398-72-0, IOX2Related Search:

Roxadustat 2-METHOXYESTRADIOL Trametinib BAY 87-2243 GO 6976 Olaparib

Glycine, N-[[1,2-dihydro-4-hydroxy-2-oxo-1-(phenylmethyl)-3-quinolinyl]carbonyl]-

N-[[4-Hydroxy-2-oxo-1-(phenylmethyl)-1,2-dihydro-3-quinolinyl]carbonyl]glycine IOX2

JICL38

N-[[1,2-Dihydro-4-hydroxy-2-oxo-1-(phenylmethyl)-3-quinolinyl]carbonyl]-glycine

(1-benzyl-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carbonyl)glycine

IOX 2, >=98%

IOX2;IOX 2;IOX-2;JICL38

IOX2

2-(1-benzyl-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxaMido)acetic acid

2-[(1-BENZYL-4-HYDROXY-2-OXOQUINOLINE-3-CARBONYL)AMINO]ACETIC ACID

N-[[4-Hydroxy-2-oxo-1-(phenylmethyl)-1,2-dihydro-3-quinolinyl]carbonyl]glycine

IOX2(Glycine)

IOX-2; IOX2; IOX 2

CS-564

DesidustatImpurity1

HIF-PH,Inhibitor,inhibit,HIF/HIF Prolyl-Hydroxylase,IOX-2,IOX2,HIFs,Hypoxia-inducible factors

931398-72-0

Inhibitors

Inhibitor