2-Propen-1-one, 3-(3,4-dihydroxy-2-Methoxyphenyl)-1-[4-hydroxy-3-(3-Methyl-2-butenyl)p henyl]-, (E)-

Product Name: 2-Propen-1-one, 3-(3,4-dihydroxy-2-Methoxyphenyl)-1-[4-hydroxy-3-(3-Methyl-2-butenyl)p henyl]-, (E)-
CAS No.: 144506-15-0
Chemical Name: 2-Propen-1-one, 3-(3,4-dihydroxy-2-Methoxyphenyl)-1-[4-hydroxy-3-(3-Methyl-2-butenyl)p henyl]-, (E)-
Synonyms: Licochalcone D, 10 mM in DMSO;(E)-3-(3,4-dihydroxy-2-methoxyphenyl)-1-[4-hydroxy-3-(3-methylbut-2-enyl)phenyl]prop-2-en-1-one;(E)-3-(3,4-Dihydroxy-2-methoxyphenyl)-1-(4-hydroxy-3-(3-methylbut-2-en-1-yl)phenyl)prop-2-en-1-one;2-Propen-1-one, 3-(3,4-dihydroxy-2-Methoxyphenyl)-1-[4-hydroxy-3-(3-Methyl-2-butenyl)p henyl]-, (E)-;2-Propen-1-one, 3-(3,4-dihydroxy-2-methoxyphenyl)-1-[4-hydroxy-3-(3-methyl-2-buten-1-yl)phenyl]-, (2E)-;Licochalcone D,Apoptosis,A375,anti-cancer,antioxidant,Reactive Oxygen Species,Nuclear factor-κB,NF-κB p65,NF-κB,Nuclear factor-kappaB,Inhibitor,anti-inflammatory,inhibit
CBNumber: CB32639128
Molecular Formula: C21H22O5
Formula Weight: 354.4
MOL File: 144506-15-0.mol

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2-Propen-1-one, 3-(3,4-dihydroxy-2-Methoxyphenyl)-1-[4-hydroxy-3-(3-Methyl-2-butenyl)p henyl]-, (E)- Property

Melting point:: 113°
Boiling point:: 590.0±50.0 °C(Predicted)
Density: 1.244±0.06 g/cm3(Predicted)
storage temp.: 4°C, protect from light
solubility: DMSO: 125 mg/mL (352.71 mM)
form: Solid
pka: 8.38±0.20(Predicted)
color: Light yellow to yellow
InChI: InChI=1S/C21H22O5/c1-13(2)4-5-15-12-16(8-10-18(15)23)17(22)9-6-14-7-11-19(24)20(25)21(14)26-3/h4,6-12,23-25H,5H2,1-3H3/b9-6+
InChIKey: RETRVWFVEFCGOK-RMKNXTFCSA-N
SMILES: C(C1=CC=C(O)C(C/C=C(/C)\C)=C1)(=O)/C=C/C1=CC=C(O)C(O)=C1OC

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0032380
Product name: LicochalconeD
Purity: 99.68%
Packaging: 1mg
Price: $171
Updated: 2021/12/16

ChemScene

Product number: CS-0032380
Product name: LicochalconeD
Purity: 99.68%
Packaging: 5mg
Price: $514
Updated: 2021/12/16

AK Scientific

Product number: 7813CR
Product name: LicochalconeD
Packaging: 5mg
Price: $738
Updated: 2021/12/16

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2-Propen-1-one, 3-(3,4-dihydroxy-2-Methoxyphenyl)-1-[4-hydroxy-3-(3-Methyl-2-butenyl)p henyl]-, (E)- Chemical Properties,Usage,Production

Chemical Properties

White crystalline powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from the rhizome of Glycyrrhiza uralensis Fisch.

Uses

Licochalcone D, a flavonoid compound mainly existing in the root of Glycyrrhiza uralensis, is a potent and orally active inhibitor of NF-kappaB (NF-κB) p65. Licochalcone D possesses antioxidant, anti-inflammatory, anti-cancer properties[1][2].

in vivo

Licochalcone D (25 and 50 mg/kg; i.g.; daily for a week) inhibits the tumor growth in a mouse xenograft model of murine melanoma B16F0 cells^[2].

Animal Model:	C57BL/6 mice, B16F0 tumor model^[2]
Dosage:	25 and 50 mg/kg
Administration:	Intragastric administration, daily for a week
Result:	Obviously lowered the tumor growth rates, the tumor growth inhibition rates were calculated to be 32.0 and 54.1% at 25 and 50 mg/kg, respectively.

IC 50

p65

References

[1] Furusawa J, et al. Glycyrrhiza inflata-derived chalcones, Licochalcone A, Licochalcone B and Licochalcone D, inhibit phosphorylation of NF-kappaB p65 in LPS signaling pathway. Int Immunopharmacol. 2009 Apr;9(4):499-507. DOI:10.1016/j.intimp.2009.01.031
[2] Si L, et al. Licochalcone D induces apoptosis and inhibits migration and invasion in human melanoma A375 cells. Oncol Rep. 2018 May;39(5):2160-2170. DOI:10.3892/or.2018.6329

2-Propen-1-one, 3-(3,4-dihydroxy-2-Methoxyphenyl)-1-[4-hydroxy-3-(3-Methyl-2-butenyl)p henyl]-, (E)- Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Propen-1-one, 3-(3,4-dihydroxy-2-Methoxyphenyl)-1-[4-hydroxy-3-(3-Methyl-2-butenyl)p henyl]-, (E)- Suppliers

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View Lastest Price from 2-Propen-1-one, 3-(3,4-dihydroxy-2-Methoxyphenyl)-1-[4-hydroxy-3-(3-Methyl-2-butenyl)p henyl]-, (E)- manufacturers

Shaanxi Haibo Biotechnology Co., Ltd

Product: Licochalcone D 144506-15-0
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 2000ton
Release date: 2023-09-01

Shanghai Standard Technology Co., Ltd.

Product: Licochalcone D 144506-15-0
Price: US $0.00/mg
Min. Order: 5mg
Purity: ≥98%(HPLC)
Supply Ability: 10 g
Release date: 2020-05-14

144506-15-0, 2-Propen-1-one, 3-(3,4-dihydroxy-2-Methoxyphenyl)-1-[4-hydroxy-3-(3-Methyl-2-butenyl)p henyl]-, (E)-Related Search:

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2-Propen-1-one, 3-(3,4-dihydroxy-2-Methoxyphenyl)-1-[4-hydroxy-3-(3-Methyl-2-butenyl)p henyl]-, (E)-

(E)-3-(3,4-dihydroxy-2-methoxyphenyl)-1-[4-hydroxy-3-(3-methylbut-2-enyl)phenyl]prop-2-en-1-one

2-Propen-1-one, 3-(3,4-dihydroxy-2-methoxyphenyl)-1-[4-hydroxy-3-(3-methyl-2-buten-1-yl)phenyl]-, (2E)-

Licochalcone D,Apoptosis,A375,anti-cancer,antioxidant,Reactive Oxygen Species,Nuclear factor-κB,NF-κB p65,NF-κB,Nuclear factor-kappaB,Inhibitor,anti-inflammatory,inhibit

Licochalcone D, 10 mM in DMSO

(E)-3-(3,4-Dihydroxy-2-methoxyphenyl)-1-(4-hydroxy-3-(3-methylbut-2-en-1-yl)phenyl)prop-2-en-1-one

144506-15-0