KPT-185

Product Name: KPT-185
CAS No.: 1333151-73-7
Chemical Name: KPT-185
Synonyms: CS-844;KPT-185;KPT-185;KPT185;KPT-185, >=98%;KPT-185 USP/EP/BP;(Z)-Isopropyl 3-(3-(3-methoxy-5-(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylate;(2Z)-3-[3-[3-Methoxy-5-(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl]-2-propenoic acid 1-methylethyl ester;2-Propenoic acid, 3-[3-[3-methoxy-5-(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl]-, 1-methylethyl ester, (2Z)-;(2Z)-3-[3-[3-Methoxy-5-(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl]-2-propenoic acid 1-methylethyl ester KPT185
CBNumber: CB32655409
Molecular Formula: C16H16F3N3O3
Formula Weight: 355.31
MOL File: 1333151-73-7.mol

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KPT-185 Property

Boiling point:: 458.8±55.0 °C(Predicted)
Density: 1.29±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: insoluble in H2O; ≥17.77 mg/mL in DMSO; ≥25.2 mg/mL in EtOH
form: solid
pka: 0.47±0.50(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 26074
Product name: KPT-185
Packaging: 5mg
Price: $62
Updated: 2024/03/01

Cayman Chemical

Product number: 26074
Product name: KPT-185
Packaging: 10mg
Price: $115
Updated: 2024/03/01

Cayman Chemical

Product number: 26074
Product name: KPT-185
Packaging: 25mg
Price: $270
Updated: 2024/03/01

ApexBio Technology

Product number: B1462
Product name: KPT-185
Packaging: 10mg
Price: $68
Updated: 2021/12/16

ApexBio Technology

Product number: B1462
Product name: KPT-185
Packaging: 10mM(in 1mL DMSO)
Price: $60
Updated: 2021/12/16

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KPT-185 Chemical Properties,Usage,Production

Uses

KPT185 acts as a novel CRM1 inhibitor used in the treatment of acute myeloid leukemia.

Biological Activity

kpt-185 is a selective and irreversible inhibitor of chromosome maintenance protein 1 (crm1) with ic50 values of 100-500nm [1].crm1 is an important nuclear protein export receptor. blocking crm1-mediated nuclear export can result in the suppression of tumors. as an inhibitor of crm1, kpt-185 binds crm1within the cys528 site and prevents crm1from interacting with tumor-suppressor proteins. in the in vitro studies on aml cell lines, kpt-185 inhibits proliferation of a variety of leukemia cells with ic50 values ranging from 100nm to 500nm. it induces cell-cycle arrest at g1 and induces apoptosis. kpt-185 also strongly affects cell colony formation. in addition, the inhibition of crm1 caused by kpt-185 induces differentiation of aml blast. besides that, kpt-185 is also found to inhibit proliferation and induce apoptosis of pancreatic cancer cells including colo-357, hpac and bxpc-3 [1, 2].

target

CRM1

References

[1] ranganathan p, yu x, na c, et al. preclinical activity of a novel crm1 inhibitor in acute myeloid leukemia. blood, 2012, 120(9): 1765-1773.
[2] azmi a s, aboukameel a, bao b, et al. selective inhibitors of nuclear export block pancreatic cancer cell proliferation and reduce tumor growth in mice. gastroenterology, 2013, 144(2): 447-456.

KPT-185 Preparation Products And Raw materials

Raw materials

Preparation Products

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KPT-185 Suppliers

China 73 France 1 India 1 United Kingdom 1 United States 13 Global 89

AdooQ BioScience, LLC

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BOC Sciences

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Target molecule Corp.

Tel: 857-239-0968
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TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
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InvivoChem

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Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
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Cckinase, Inc.

Tel: +1 (732)236-3202
Email: sales@cckinase.com
Country: United States
ProdList: 2738
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Aladdin Scientific

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ApexBio Technology

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Cayman Chemical Company

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United States Biological

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Matrix Scientific

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NE Scientific

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View Lastest Price from KPT-185 manufacturers

Career Henan Chemical Co

Product: KPT-185 1333151-73-7
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 200kg
Release date: 2020-01-10

1333151-73-7, KPT-185Related Search:

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2-Propenoic acid, 3-[3-[3-methoxy-5-(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl]-, 1-methylethyl ester, (2Z)-

(2Z)-3-[3-[3-Methoxy-5-(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl]-2-propenoic acid 1-methylethyl ester KPT185

KPT-185

(2Z)-3-[3-[3-Methoxy-5-(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl]-2-propenoic acid 1-methylethyl ester

KPT-185, >=98%

KPT-185;KPT185

(Z)-Isopropyl 3-(3-(3-methoxy-5-(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylate

CS-844

KPT-185 USP/EP/BP

1333151-73-7

133315-73-7

Inhibitors