CNTO 148
- Product Name
- CNTO 148
- CAS No.
- 476181-74-5
- Chemical Name
- CNTO 148
- Synonyms
- Simponi;CNTO 148;Golimumab;Research Grade Golimumab;MK-8259|||SCH 900259|||CNTO-148;Research Grade Golimumab (DHB94404)
- CBNumber
- CB32657887
- Formula Weight
- 0
- MOL File
- Mol file
CNTO 148 Property
- storage temp.
- Store at -20°C
- form
- Liquid
- color
- Colorless to light yellow
Safety
- Hazardous Substances Data
- 476181-74-5(Hazardous Substances Data)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H334May cause allergy or asthma symptoms or breathing difficulties if inhaled
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P285In case of inadequate ventilation wear respiratory protection.
P304+P341IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342+P311IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- ATB0023418
- Product name
- GOLIMUMAB
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $498.11
- Updated
- 2021/12/16
CNTO 148 Chemical Properties,Usage,Production
Description
The proinflammatory cytokine tumor necrosis factor-alpha (TNF-α) has been implicated as the primary mediator of articular inflammation in diseases such as RA, PsA, and AS. Targeting TNF-a has been a successful strategy in the intervention of a range of immunoinflammatory disorders. Biologics have risen to the forefront of TNF-α blockade with infliximab, a chimeric monoclonal antibody (mAb), and etanercept, a fusion protein comprised of the ligand-binding segment of the soluble TNF receptor, reaching the market in the late 1990s for the initial indication of RA. Since then, their use has expanded to other diseases of inflammatory etiology, and two additional TNF-α inhibitors have joined the competition. Golimumab, a human anti-TNF-α mAb that binds to both soluble and transmembrane forms of TNF-a, is the first once-monthly subcutaneous agent to enter the market and is currently approved for the treatment of RA in combination with methotrexate (MTX), PsA alone or in combination with MTX, and AS. .
Originator
Centocor Ortho Biotech (US)
Uses
Treatment of allergic asthma.
brand name
Simponi
Side effects
The most common adverse reactions, occurring with an incidence >5%, were upper respiratory tract infection and nasopharyngitis. Regarding drug interactions, live vaccines should not be administered while being treated with golimumab. As an increased risk of serious infection has been associated with concomitant use of abatacept and anakinra, combination of these drugs is not recommended. Also, golimumab treatment should not be initiated in patients with an active infection. Furthermore, patients should be warned about the higher incidence of malignancies observed with anti-TNF-a therapy and increased risks of worsening or new onset of heart failure, of exacerbation or new onset of demyelinating disease, and of hepatitis B reactivation.
CNTO 148 Preparation Products And Raw materials
Raw materials
Preparation Products
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