Tropic acid Property

Melting point:

116-118 °C(lit.)

Boiling point:

234.38°C (rough estimate)

Density 

1.1097 (rough estimate)

refractive index 

1.4500 (estimate)

storage temp. 

Store below +30°C.

solubility 

methanol: 0.1 g/mL, clear

pka

pK1:3.53 (25°C)

form 

Crystalline Powder

color 

White to off-white

optical activity

+14.820 (H2O)

Water Solubility 

20 g/L (20 ºC)

Merck 

13,9849

InChIKey

JACRWUWPXAESPB-UHFFFAOYSA-N

CAS DataBase Reference

529-64-6(CAS DataBase Reference)

NIST Chemistry Reference

Tropic acid(529-64-6)

EPA Substance Registry System

Benzeneacetic acid, .alpha.-(hydroxymethyl)-(529-64-6)

Safety

Hazard Codes 

Xi

Risk Statements 

22-41-37/38-36/37/38

Safety Statements 

22-24/25-36/37/39-36-26

WGK Germany 

3

Hazard Note 

Irritant

HS Code 

29181980

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

Tropic acid Chemical Properties,Usage,Production

Description

Tropic acid (Tropate) is a chiral substance, existing as either a racemic mixture or as a single enantiomer. Tropate is classified as a beta hydroxy acid or a Beta hydroxy acid derivative. Beta hydroxy acids are compounds containing a carboxylic acid substituted with a hydroxyl group on the C3 carbon atom. Tropate is considered to be soluble (in water) and acidic. Tropate can be synthesized from hydratropic acid and propionic acid. Tropate can be synthesized into tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate. Tropic acid is proposed be used topicaly for the treatment of wrinkles.

Chemical Properties

white to off-white crystalline powder

Uses

Tropic Acid is a benzoic acid derivative and thus carries anti-fungal properties.

Preparation

The process for preparing tropic acid which comprises reacting sodium phenylacetate with magnesium and isopropyl chloride, reacting the resulting sodium salt of alpha-carboxybenzylmagnesium chloride with formaldehyde, and hydrolyzing the resulting complex.

Definition

ChEBI: Tropic acid is a 3-hydroxy monocarboxylic acid that is propionic acid in which one of the hydrogens at position 2 is substituted by a phenyl group, and one of the methyl hydrogens is substituted by a hydroxy group. It has a role as a human xenobiotic metabolite. It is functionally related to a propionic acid and a hydratropic acid. It is a conjugate acid of a tropate.

Purification Methods

Crystallise tropic acid from water or *benzene. [Beilstein 10 IV 664.]