N-((S)-1-(((R)-1-Hydroxy-3-Methylbutyl)aMino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxaMide

ChemicalBook > CAS DataBase List > N-((S)-1-(((R)-1-Hydroxy-3-Methylbutyl)aMino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxaMide

N-((S)-1-(((R)-1-Hydroxy-3-Methylbutyl)aMino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxaMide

Product Name: N-((S)-1-(((R)-1-Hydroxy-3-Methylbutyl)aMino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxaMide
CAS No.: 289472-78-2
Chemical Name: N-((S)-1-(((R)-1-Hydroxy-3-Methylbutyl)aMino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxaMide
Synonyms: Bortezomib USP IMP I;Bortezomib USP Impurity I;Bortezomib (EP) Impurity E;Bortezomib USP Related Compoud I;SR-Isomer, Bortezomib Impurity E;Bortezomib Impurity 2 (S,R-Isomer);Bortezomib (1S,2R) Isomer Impurity;(R)-Hydroxy Des(boric Acid) BortezoMib;Bortezomib impurity 5/Bortezomib EP Impurity E;(S,R)-Bortezomib Hydroxyisopentyl Amide Analog
CBNumber: CB32661929
Molecular Formula: C19H24N4O3
Formula Weight: 356.42
MOL File: 289472-78-2.mol

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N-((S)-1-(((R)-1-Hydroxy-3-Methylbutyl)aMino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxaMide Property

Boiling point:: 672.0±55.0 °C(Predicted)
Density: 1.199±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
pka: 11.90±0.46(Predicted)
form: Solid
color: White to Off-White

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: H935900
Product name: (R)-HydroxyDes(boricAcid)Bortezomib
Packaging: 25mg
Price: $1455
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CCH0032707
Product name: N-((S)-1-(((R)-1-HYDROXY-3-METHYLBUTYL)AMINO)-1-OXO-3-PHENYLPROPAN-2-YL)PYRAZINE-2-CARBOXAMIDE
Purity: 95.00%
Packaging: 5MG
Price: $498.71
Updated: 2021/12/16

Alichem

Product number: 289472782
Product name: N-((S)-1-(((R)-1-Hydroxy-3-methylbutyl)amino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxamide
Packaging: 1g
Price: $768
Updated: 2021/12/16

Chemenu

Product number: CM168279
Product name: N-((S)-1-(((R)-1-hydroxy-3-methylbutyl)amino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxamide
Purity: 95%+
Packaging: 1g
Price: $893
Updated: 2021/12/16

Crysdot

Product number: CD11152976
Product name: N-((S)-1-(((R)-1-Hydroxy-3-methylbutyl)amino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxamide
Purity: 95+%
Packaging: 1g
Price: $947
Updated: 2021/12/16

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N-((S)-1-(((R)-1-Hydroxy-3-Methylbutyl)aMino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxaMide Chemical Properties,Usage,Production

Uses

(R)-Hydroxy Des(boric acid) Bortezomib is an impurity in the synthesis of Bortezomib (B675700), the first proteasome inhibitor to be approved by the US FDA for multiple myeloma, a blood cancer. A reversible inhibitor of the 26S proteasome-a barrel-shaped multiprotein particle found in the nucleus and cytosol of all eukaryotic cells. Targets the ubiquitin-proteasome pathway.

N-((S)-1-(((R)-1-Hydroxy-3-Methylbutyl)aMino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxaMide Preparation Products And Raw materials

Raw materials

Preparation Products

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289472-78-2, N-((S)-1-(((R)-1-Hydroxy-3-Methylbutyl)aMino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxaMideRelated Search:

2-PyrazinecarboxaMide, N,N',N''-[2,4,6-boroxintriyltris[[(1R)-3-Methylbutylidene]iMino[(1S)-2-oxo-1-(phenylMethyl)-2,1-ethanediyl]]]tris- BORTEZOMIB-PINANEDIOL Bortezomib Impurity 2 (Mixture of (1S,2R)-Isomer and (1R,2R)-Isomer) Bortezomib Impurity 1 (R,S-Isomer) Boronic acid, B-[(1S)-3-Methyl-1-[[(2R)-1-oxo-3-phenyl-2-[(2-pyrazinylcarbonyl)aMino]propyl]aMino]butyl]- BortezoMib IMpurity 2 (RR-IsoMer) 2-PyrazinecarboxaMide, N-[(1S)-2-[[(1R)-1-hydroperoxy-3-Methylbutyl]aMino]-2-oxo-1-(phenylMethyl)ethyl]- (S)-N-(1-AMino-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxaMide ((R)-3-Methyl-1-((R)-3-phenyl-2-(pyrazine-2-carboxaMido)propanaMido)butyl)boronic acid 2-PyrazinecarboxaMide, N-[(1S)-2-[[(1S)-1-hydroperoxy-3-Methylbutyl]aMino]-2-oxo-1-(phenylMethyl)ethyl]- ((S)-3-Methyl-1-((S)-3-phenyl-2-(pyrazine-2-carboxaMido)propanaMido)butyl)boronic acid N-((S)-1-(((S)-1-Hydroxy-3-Methylbutyl)aMino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxaMide

2-PyrazinecarboxaMide, N-[(1S)-2-[[(1R)-1-hydroxy-3-Methylbutyl]aMino]-2-oxo-1-(phenylMethyl)ethyl]-

(R)-Hydroxy Des(boric Acid) BortezoMib

(N-[(1R)-1-hydroxy-3-Methylbutyl]-Nα-(pyrazin-2-ylcarbonyl)-L-phenylalaninaMide

Bortezomib Impurity 2 (SR-Isomer, Bortezomib Impurity E)

SR-Isomer, Bortezomib Impurity E

Bortezomib Impurity 2 (S,R-Isomer)

N-((S)-1-(((R)-1-Hydroxy-3-Methylbutyl)aMino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxaMide

BortezoMib IMpurity 2 (SR-IsoMer, EP IMpurity E)

Bortezomib USP Related Compoud I

N-[(1S)-2-[[(1R)-1-Hydroxy-3-methylbutyl]amino]-2-oxo-1-(phenylmethyl)ethyl]-2-pyrazinecarboxamide

N-[(1S)-2-[[(1R)-1-hydroxy-3-methylbutyl]amino]-2-oxo-1-(phenylmethyl)ethyl]pyrazin

Bortezomib (1S,2R) Isomer Impurity

Bortezomib impurity 5/Bortezomib EP Impurity E

Bortezomib USP IMP I

Bortezomib (EP) Impurity E

Bortezomib USP Impurity I

Bortezomib Related Compund I/ (S,R)-Bortezomib Hydroxyisopentyl Amide Analog (Bortezomib Hydroxy S,R-Isomer Impurity)

(S,R)-Bortezomib Hydroxyisopentyl Amide Analog

N-((S)-1-(((R)-1-hydroxy-3-methylbutyl)amino)-1-oxo-3-phenylpropan

N-((S)-1-(((R)-1-hydroxy-3-methylbutyl)amino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxamide? (Bortezomib Impurity）

289472-78-2