ChemicalBook > CAS DataBase List > N-((S)-1-(((S)-1-Hydroxy-3-Methylbutyl)aMino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxaMide

N-((S)-1-(((S)-1-Hydroxy-3-Methylbutyl)aMino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxaMide

Product Name
N-((S)-1-(((S)-1-Hydroxy-3-Methylbutyl)aMino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxaMide
CAS No.
289472-81-7
Chemical Name
N-((S)-1-(((S)-1-Hydroxy-3-Methylbutyl)aMino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxaMide
Synonyms
Bortezomib EP IMP M;Bortezomib USP IMP J;Bortezomib Impurity D;Bortezomib Impurity J;Bortezomib Impurity 48;Bortezomib USP Impurity J;BortezomibHydroxy(1S,2S)-Isomer;Bortezomib USP Related Compoud J;(S)-Hydroxy Des(boric Acid) BortezoMib;(S,S)-Bortezomib Hydroxyisopentyl Amide Analog
CBNumber
CB02661665
Molecular Formula
C19H24N4O3
Formula Weight
356.42
MOL File
289472-81-7.mol
More
Less

N-((S)-1-(((S)-1-Hydroxy-3-Methylbutyl)aMino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxaMide Property

Boiling point:
672.0±55.0 °C(Predicted)
Density 
1.199±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
Chloroform (Slightly), Methanol (Slightly)
pka
11.90±0.46(Predicted)
form 
Solid
color 
White to Off-White
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

N-Bromosuccinimide Price

TRC
Product number
H935905
Product name
(S)-HydroxyDes(boricAcid)Bortezomib
Packaging
5mg
Price
$1455
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CCH0032708
Product name
N-((S)-1-(((S)-1-HYDROXY-3-METHYLBUTYL)AMINO)-1-OXO-3-PHENYLPROPAN-2-YL)PYRAZINE-2-CARBOXAMIDE
Purity
95.00%
Packaging
5MG
Price
$496.22
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CCH0032708
Product name
N-((S)-1-(((S)-1-HYDROXY-3-METHYLBUTYL)AMINO)-1-OXO-3-PHENYLPROPAN-2-YL)PYRAZINE-2-CARBOXAMIDE
Purity
95.00%
Packaging
1G
Price
$1365
Updated
2021/12/16
Crysdot
Product number
CD11152974
Product name
N-((S)-1-(((S)-1-Hydroxy-3-methylbutyl)amino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxamide
Purity
95+%
Packaging
1g
Price
$947
Updated
2021/12/16
Chemenu
Product number
CM168043
Product name
N-((S)-1-(((S)-1-hydroxy-3-methylbutyl)amino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxamide
Purity
95%+
Packaging
1g
Price
$1365
Updated
2021/12/16
More
Less

N-((S)-1-(((S)-1-Hydroxy-3-Methylbutyl)aMino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxaMide Chemical Properties,Usage,Production

Uses

(S)-Hydroxy Des(boric Acid) Bortezomib is an impurity in the synthesis of Bortezomib (B675700), the first proteasome inhibitor to be approved by the US FDA for multiple myeloma, a blood cancer. A reversible inhibitor of the 26S proteasome-a barrel-shaped multiprotein particle found in the nucleus and cytosol of all eukaryotic cells. Targets the ubiquitin-proteasome pathway.

N-((S)-1-(((S)-1-Hydroxy-3-Methylbutyl)aMino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxaMide Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

N-((S)-1-(((S)-1-Hydroxy-3-Methylbutyl)aMino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxaMide Suppliers

J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
94657
Advantage
76
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
Jiangsu Vcare PharmaTech Co., Ltd.
Tel
025-58741518; 18013018875
Fax
+86-25-58744115
Email
sales@vcarepharmatech.com
Country
China
ProdList
310
Advantage
61
BOC Sciences
Tel
1-631-485-4226; 16314854226
Email
info@bocsci.com
Country
United States
ProdList
14055
Advantage
65
Beijing Comparison Pharmaceutical Technology Co., Ltd
Tel
010-010-52878169 15801002657
Email
sales@bjcomparison.com
Country
China
ProdList
4938
Advantage
58
Alputon Inc.
Tel
021-60753308-14013
Fax
021-60753309
Country
China
ProdList
137
Advantage
55
Shanghai TaoSu Biochemical Technology Co., Ltd.
Tel
021-33632979
Fax
021-34692979
Email
info@tsbiochem.com
Country
China
ProdList
8065
Advantage
58
ChemStrong Scientific Co.,Ltd
Tel
0755-0755-66853366 13670046396
Fax
0755-28363542
Email
sales@chem-strong.com
Country
China
ProdList
18043
Advantage
56
Shanghai Kewel Chemical Co., Ltd.
Tel
021-64609169 18901607656
Fax
021-64609160
Email
greensnown@163.com
Country
China
ProdList
9906
Advantage
50
Nanjing XiZe Biotechnology CO., Ltd.
Tel
025-66023220 0086-15250997978
Fax
025-58362220
Email
1511893459@qq.com
Country
China
ProdList
7850
Advantage
55

289472-81-7, N-((S)-1-(((S)-1-Hydroxy-3-Methylbutyl)aMino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxaMideRelated Search:


  • 2-PyrazinecarboxaMide, N-[(1S)-2-[[(1S)-1-hydroxy-3-Methylbutyl]aMino]-2-oxo-1-(phenylMethyl)ethyl]-
  • (S)-Hydroxy Des(boric Acid) BortezoMib
  • Bortezomib Impurity 48
  • Bortezomib Impurity J
  • N-[(2S)-1-[[(1S)-1-hydroxy-3-methylbutyl]amino]-1-oxo-3-phenylpropan-2-yl]pyrazine-2-carboxamide
  • Bortezomib USP IMP J
  • (N-[(1S)-1-hydroxy-3-Methylbutyl]-Nα-(pyrazin-2-ylcarbonyl)-L-phenylalaninaMide
  • Bortezomib Impurity D
  • Bortezomib USP Related Compoud J
  • N-[(1S)-2-[[(1S)-1-hydroxy-3-methylbutyl]amino]-2-oxo-1-(phenylmethyl)ethyl]-2-Pyrazinecarboxamide
  • N-[(1S)-2-[[(1S)-1-hydroxy-3-methylbutyl]amino]-2-oxo-1-(phenylmethyl)ethyl]-pyrazi
  • Bortezomib USP Impurity J
  • Bortezomib Related Compund J/ (S,S)-Bortezomib Hydroxyisopentyl Amide Analog (Bortezomib Hydroxy S,S-Isomer Impurity)
  • BortezomibHydroxy(1S,2S)-Isomer
  • (S,S)-Bortezomib Hydroxyisopentyl Amide Analog
  • Bortezomib EP IMP M
  • N-[(2S)-1-[[(1S)-1-hydroxy-3-methylbutyl]amino]-1-oxo-3-phenylprop
  • N-((S)-1-(((S)-1-Hydroxy-3-Methylbutyl)aMino)-1-oxo-3-phenyl
  • 289472-81-7
  • Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals