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AMT HYDROCHLORIDE

Product Name
AMT HYDROCHLORIDE
CAS No.
21463-31-0
Chemical Name
AMT HYDROCHLORIDE
Synonyms
4H-1;AMT HCL;AMT HYDROCHLORIDE;2-AMINO-5,6-DIHYDRO-6-METHYL-4H-1,3-THIAZINE HCL;2-AMINO-5,6-DIHYDRO-6-METHYL-4H-1,3-THIAZINE HYDROCHLORIDE;5,6-DIHYDRO-6-METHYL-4H-1,3-THIAZIN-2-AMINE, HYDROCHLORIDE;4H-1,3-Thiazin-2-amine, 5,6-dihydro-6-methyl-, hydrochloride (1:1)
CBNumber
CB3266443
Molecular Formula
C5H10N2S.ClH
Formula Weight
166.67
MOL File
21463-31-0.mol
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AMT HYDROCHLORIDE Property

Melting point:
146-150°C
storage temp. 
0-6°C
solubility 
DMF: >8 mg/ml; DMSO: >16 mg/ml; Ethanol: >25 mg/ml; Water: >25 mg/ml
form 
A crystalline solid
color 
White to off-white
Water Solubility 
Soluble to 10 mM in water
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Safety

HS Code 
29309099
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P337+P313IF eye irritation persists: Get medical advice/attention.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
81010
Product name
AMT (hydrochloride)
Purity
≥98%
Packaging
5mg
Price
$62
Updated
2024/03/01
Cayman Chemical
Product number
81010
Product name
AMT (hydrochloride)
Purity
≥98%
Packaging
10mg
Price
$109
Updated
2024/03/01
Cayman Chemical
Product number
81010
Product name
AMT (hydrochloride)
Purity
≥98%
Packaging
50mg
Price
$448
Updated
2024/03/01
Cayman Chemical
Product number
81010
Product name
AMT (hydrochloride)
Purity
≥98%
Packaging
100mg
Price
$711
Updated
2024/03/01
Tocris
Product number
0871
Product name
AMThydrochloride
Packaging
10
Price
$125
Updated
2021/12/16
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AMT HYDROCHLORIDE Chemical Properties,Usage,Production

Description

AMT is a potent, relatively selective inhibitor of iNOS with a Ki of 4.2 nM in mouse macrophages. It inhibits other isoforms of NOS, but at higher concentrations; the IC50 values for rat nNOS and bovine eNOS are 34 and 150 nM, respectively.

Chemical Properties

white to off-white powder

Uses

AMT Hydrochloride is a potent and selective inhibitors of inducible nitric oxide synthase, which may lead to therapeutic applications in the treatment of inflammatory and autoimmune diseases.

Biological Activity

Potent, selective and reversible inhibitor of iNOS (IC 50 = 3.6 nM; approximately 30 and 40 times selective over nNOS and eNOS respectively).

storage

Desiccate at +4°C

References

[1] M NAKANE. Novel potent and selective inhibitors of inducible nitric oxide synthase.[J]. Molecular Pharmacology, 1995, 47 4: 831-834.

AMT HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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AMT HYDROCHLORIDE Suppliers

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21463-31-0, AMT HYDROCHLORIDERelated Search:

AMT HYDROCHLORIDE

  • 5,6-DIHYDRO-6-METHYL-4H-1,3-THIAZIN-2-AMINE, HYDROCHLORIDE
  • AMT HYDROCHLORIDE
  • AMT HCL
  • 2-AMINO-5,6-DIHYDRO-6-METHYL-4H-1,3-THIAZINE HYDROCHLORIDE
  • 2-AMINO-5,6-DIHYDRO-6-METHYL-4H-1,3-THIAZINE HCL
  • 4H-1
  • 4H-1,3-Thiazin-2-amine, 5,6-dihydro-6-methyl-, hydrochloride (1:1)
  • 21463-31-0
  • C5H11ClN2S
  • C5H10N2SHCl
  • Biochemicals and Reagents
  • BioChemical
  • L to O
  • Nitric Oxide Synthase (iNOS)
  • Enzyme Inhibitors
  • Enzymes, Inhibitors, and Substrates
  • Enzyme Inhibitors by Enzyme