AMT HYDROCHLORIDE Property

Melting point:

146-150°C

storage temp. 

0-6°C

solubility 

DMF: >8 mg/ml; DMSO: >16 mg/ml; Ethanol: >25 mg/ml; Water: >25 mg/ml

form 

A crystalline solid

Water Solubility 

Soluble to 10 mM in water

Safety

HS Code 

29309099

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P337+P313IF eye irritation persists: Get medical advice/attention.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

AMT HYDROCHLORIDE Chemical Properties,Usage,Production

Description

AMT is a potent, relatively selective inhibitor of iNOS with a K_i of 4.2 nM in mouse macrophages. It inhibits other isoforms of NOS, but at higher concentrations; the IC₅₀ values for rat nNOS and bovine eNOS are 34 and 150 nM, respectively.

Chemical Properties

white to off-white powder

Uses

AMT Hydrochloride is a potent and selective inhibitors of inducible nitric oxide synthase, which may lead to therapeutic applications in the treatment of inflammatory and autoimmune diseases.

Biological Activity

Potent, selective and reversible inhibitor of iNOS (IC 50 = 3.6 nM; approximately 30 and 40 times selective over nNOS and eNOS respectively).

storage

Desiccate at +4°C