GDC-0152

ChemicalBook > CAS DataBase List > GDC-0152

Product Name: GDC-0152
CAS No.: 873652-48-3
Chemical Name: GDC-0152
Synonyms: CS-2247;GDC-0152;GDC0152;GDC 0152.;GDC-0152 (RG7419);GDC-0152 USP/EP/BP;GDC-0152; GDC0152; GDC 0152.;GDC-0152,IAP,Inhibitor,inhibit,GDC 0152;L-Prolinamide, N-methyl-L-alanyl-(2S)-2-cyclohexylglycyl-N-(4-phenyl-1,2,3-thiadiazol-5-yl)-;(S)-1-((S)-2-Cyclohexyl-2-((S)-2-(methylamino)propanamido)acetyl)-N-(4-phenyl-1,2,3-thiadiazol-5-yl)pyrrolidine-2-carboxamide
CBNumber: CB32665154
Molecular Formula: C25H34N6O3S
Formula Weight: 498.64
MOL File: 873652-48-3.mol

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GDC-0152 Property

Melting point:: 175-177oC
storage temp.: -20°C Freezer
solubility: DMSO (Slightly)
form: Solid
color: White

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 17810
Product name: GDC-0152
Purity: ≥95%
Packaging: 1mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 17810
Product name: GDC-0152
Purity: ≥95%
Packaging: 5mg
Price: $183
Updated: 2024/03/01

Cayman Chemical

Product number: 17810
Product name: GDC-0152
Purity: ≥95%
Packaging: 10mg
Price: $299
Updated: 2024/03/01

TRC

Product number: G299920
Product name: GDC0152
Packaging: 5mg
Price: $150
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: INB0004770
Product name: N-METHYL-L-ALANYL-(2S)-2-CYCLOHEXYLGLYCYL-N-(4-PHENYL-1,2,3-THIADIAZOL-5-YL)-L-PROLINAMIDE
Purity: 95.00%
Packaging: 5MG
Price: $497.29
Updated: 2021/12/16

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GDC-0152 Chemical Properties,Usage,Production

Uses

GDC 0152 is a peptidomimetic small molecule antagonist of inhibitor of apoptosis (IAP) proteins with antitumor activity.

Biological Activity

gdc-0152 is a potent small-molecule antagonist of inhibitor of apoptosis (iap) proteins, including ml-iap, xiap, ciap1 and ciap2, that binds to the bir domain of ml-iap and the bir3 domains of xiap, ciap1 and ciap2 with values of inhibition constant ki of 14 nm, 28 nm, 17 nm and 43 nm respectively. gdc-0152 potentially inhibits tumor growth of breast cancer by promoting ciap1 degradation and inducing caspase-3/7 activation which result in the decreasing of cell viability of breast cancer cells with normal epithelial cells unaffected. in recent studies, gdc-0152 shows its ability to disrupt the binding of xiap to caspase-9 and the association of ml-iap, ciap1 and ciap2 with smac in hek293t cells.flygare ja, beresini m, budha n, chan h, chan it, cheeti s, cohen f, deshayes k, doerner k, eckhardt sg, elliott lo, feng b, franklin mc, reisner sf, gazzard l, halladay j, hymowitz sg, la h, lorusso p, maurer b, murray l, plise e, quan c, stephan jp, young sg, tom j, tsui v, um j, varfolomeev e, vucic d, wagner aj, wallweber hj, wang l, ware j, wen z, wong h, wong jm, wong m, wong s, yu r, zobel k, fairbrother wj. discovery of a potent small-molecule antagonist of inhibitor of apoptosis (iap) proteins and clinical candidate for the treatment of cancer (gdc-0152). j med chem. 2012;55(9):4101-4113

target

XIAP

GDC-0152 Preparation Products And Raw materials

Raw materials

Preparation Products

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873652-48-3, GDC-0152Related Search:

Ceritinib TG101209 MK-2206 2HCl (2S)-1-[3-Ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-2-piperidineethanol Veliparib Birinapant

GDC-0152

(S)-1-((S)-2-Cyclohexyl-2-((S)-2-(methylamino)propanamido)acetyl)-N-(4-phenyl-1,2,3-thiadiazol-5-yl)pyrrolidine-2-carboxamide

L-Prolinamide, N-methyl-L-alanyl-(2S)-2-cyclohexylglycyl-N-(4-phenyl-1,2,3-thiadiazol-5-yl)-

GDC0152;GDC 0152.

CS-2247

GDC-0152; GDC0152; GDC 0152.

GDC-0152 USP/EP/BP

GDC-0152,IAP,Inhibitor,inhibit,GDC 0152

GDC-0152 (RG7419)

873652-48-3

Inhibitors

Inhibitor