ChemicalBook > CAS DataBase List > McMMAD

McMMAD

Product Name: McMMAD
CAS No.: 1401963-15-2
Chemical Name: McMMAD
Synonyms: McMMAD;Mc-MMAD;Mc MMAD;MC MMAD; MCMMAD;N-[6-(2,5-Dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-N-methyl-L-valyl-N-[(1S,2R)-2-methoxy-4-[(2S)-2-[(1R,2R)-1-methoxy-2-methyl-3-oxo-3-[[(1S)-2-phenyl-1-(2-thiazolyl)ethyl]amino]propyl]-1-pyrrolidinyl]-1-[(1S)-1-methylpropyl]-4-oxobutyl]-N-methyl-L-valinamide;L-Valinamide, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-N-methyl-L-valyl-N-[(1S,2R)-2-methoxy-4-[(2S)-2-[(1R,2R)-1-methoxy-2-methyl-3-oxo-3-[[(1S)-2-phenyl-1-(2-thiazolyl)ethyl]amino]propyl]-1-pyrrolidinyl]-1-[(1S)-1-methylpropyl]-4-oxobutyl]-N-methyl-
CBNumber: CB32666656
Molecular Formula: C51H77N7O9S
Formula Weight: 964.26358
MOL File: 1401963-15-2.mol

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McMMAD Property

Boiling point:: 1054.1±65.0 °C(Predicted)
Density: 1.168±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C,unstable in solution, ready to use.
solubility: DMSO: ≥ 100 mg/mL (103.71 mM); Water: < 0.1 mg/mL (insoluble)
form: Powder
pka: 13.63±0.46(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-1615
Product name: Mc-MMAD
Purity: 98.50%
Packaging: 1mg
Price: $660
Updated: 2021/12/16

ChemScene

Product number: CS-1615
Product name: Mc-MMAD
Purity: 98.50%
Packaging: 5mg
Price: $1116
Updated: 2021/12/16

ChemScene

Product number: CS-1615
Product name: Mc-MMAD
Purity: 98.50%
Packaging: 10mg
Price: $1710
Updated: 2021/12/16

Crysdot

Product number: CD31003618
Product name: Mc-MMAD
Purity: 98+%
Packaging: 1mg
Price: $750
Updated: 2021/12/16

Chemenu

Product number: CM190456
Product name: Mc-MMAD
Purity: 98%
Packaging: 10mg
Price: $868
Updated: 2021/12/16

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McMMAD Chemical Properties,Usage,Production

Uses

Mc-MMAD is a protective group (maleimidocaproyl)-conjugated MMAD. MMAD is a potent tubulin inhibitor. Mc-MMAD is a agent-linker conjugate for ADC.

IC 50

Auristatin

References

[1] Antibody-drug conjugates Patent: WO 2013068874 A1

McMMAD Preparation Products And Raw materials

Raw materials

Preparation Products

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1401963-15-2, McMMADRelated Search:

VcMMAD MonoMethylauristatin F McMMAE MC-MMAF MonoMethyl Dolastatin 10

Mc MMAD

McMMAD

Mc-MMAD

N-[6-(2,5-Dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-N-methyl-L-valyl-N-[(1S,2R)-2-methoxy-4-[(2S)-2-[(1R,2R)-1-methoxy-2-methyl-3-oxo-3-[[(1S)-2-phenyl-1-(2-thiazolyl)ethyl]amino]propyl]-1-pyrrolidinyl]-1-[(1S)-1-methylpropyl]-4-oxobutyl]-N-methyl-L-valinamide

MC MMAD; MCMMAD

L-Valinamide, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-N-methyl-L-valyl-N-[(1S,2R)-2-methoxy-4-[(2S)-2-[(1R,2R)-1-methoxy-2-methyl-3-oxo-3-[[(1S)-2-phenyl-1-(2-thiazolyl)ethyl]amino]propyl]-1-pyrrolidinyl]-1-[(1S)-1-methylpropyl]-4-oxobutyl]-N-methyl-

1401963-15-2

C51H77N7O9S

ADCs

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