SR2516
- Product Name
- SR2516
- CAS No.
- 1061353-68-1
- Chemical Name
- SR2516
- Synonyms
- SR2516;VS4817;VS-4718;SR-2516;SR-2156;PND1186;SR 2516;CS-1780;VC-4718;PND-1186
- CBNumber
- CB32666676
- Molecular Formula
- C25H26F3N5O3
- Formula Weight
- 501.5
- MOL File
- 1061353-68-1.mol
SR2516 Property
- Boiling point:
- 654.0±55.0 °C(Predicted)
- Density
- 1.334±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- ≥50.2 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
- form
- solid
- pka
- 14.58±0.46(Predicted)
- color
- White to gray
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 17668
- Product name
- PND1186
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $57
- Updated
- 2024/03/01
- Product number
- 17668
- Product name
- PND1186
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $275
- Updated
- 2024/03/01
- Product number
- 17668
- Product name
- PND1186
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $35
- Updated
- 2021/12/16
- Product number
- 17668
- Product name
- PND1186
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $100
- Updated
- 2024/03/01
- Product number
- 17668
- Product name
- PND1186
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $179
- Updated
- 2024/03/01
SR2516 Chemical Properties,Usage,Production
Uses
PND-1186 is a FAK inihbitor which selectively promotes tumor cell apoptosis in 3D environments.
Synthesis
209960-91-8
1061358-71-1
1061353-68-1
General procedure for the synthesis of 2-((2-((2-methoxy-4-morpholinophenyl)amino)-5-(trifluoromethyl)pyridin-4-yl)amino)-N-methylbenzamide from 2-methoxy-4-morpholinophenyl)amino)-5-(trifluoromethyl)pyridin-4-yl)amino)-N-methylbenzamide: In a microwave tube, 2-{[2-chloro-5- (trifluoromethyl)-4-pyridinyl]amino}-N-methylbenzamide (Intermediate 1, 50 mg, 0.152 mmol) was mixed with 2-methoxy-4-morpholinoaniline (148 mg, 0.607 mmol), 1M hydrochloric acid (0.303 mL, 0.303 mmol), 1,4-dioxane (0.2 mL) and water (2.5 mL). The mixture was placed in a microwave reactor and irradiated at 170°C for 25 minutes. After completion of the reaction, the crude product was collected by filtration and the filtrate was purified by reversed-phase high performance liquid chromatography (HPLC) to afford the target compound 2-((2-((2-methoxy-4-morpholinophenyl)amino)-5-(trifluoromethyl)pyridin-4-yl)amino)-N-methylbenzamide (35.5 mg, 0.071 mmol, 46.7% yield). Mass spectrum (MS): molecular weight of molecular formula C25H26F3N5O3 (M) = 471.48, (M+H)+ =472; 1H NMR (400 MHz, methanol-d4) δppm 2.88 (s, 3H), 3.05-3.14 (m, 4H), 3.78-3.91 (m, 7H), 6.45 (s, 1H), 6.52 ( dd, J=8.59,2.53Hz, 1H), 6.64 (d, J=2.53Hz, 1H), 7.03-7.13 (m, 1H), 7.30 (d, J=8.59Hz, 1H), 7.40-7.50 (m, 2H), 7.61 (dd, J=7.83,1.26Hz, 1H), 8.10 (s, 1H).
in vivo
PND-1186 (30 mg/kg or 100 mg/kg; subcutaneously; injected subcutaneously in the neck region) inhibits 4T1 subcutaneous tumor growth by induction of apoptosis[1].
| Animal Model: | BALB/c mice[1] |
| Dosage: | 30 mg/kg or 100 mg/kg |
| Administration: | Injected (100 μL) subcutaneously in the neck region; every 12 h (twice-daily, b.i.d.) for 5 days. |
| Result: | 100 mg/kg treatment significantly reduced final 4T1 tumor weight 2-fold whereas 30 mg/kg treatment slightly reduced final tumor weight but was not significantly different compared to control. |
target
FAK
storage
Store at -20°C
References
[1] Patent: WO2009/105498, 2009, A1. Location in patent: Page/Page column 27-28
SR2516 Preparation Products And Raw materials
Raw materials
Preparation Products
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