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Mc-Val-Cit-PABC-PNP

Product Name
Mc-Val-Cit-PABC-PNP
CAS No.
159857-81-5
Chemical Name
Mc-Val-Cit-PABC-PNP
Synonyms
Mc-Val-Cit-PABC-PNP;MC-Val-Cit-PAB-PNP;MC-VC-PAB-PNP;MC-Val-Cit-PABC;L-Ornithinamide;MC-VAL-CIT-PAB-PNB;SKL361;CS-1787;AK-32171;VCMMAE linker
CBNumber
CB32667895
Molecular Formula
C35H43N7O11
Formula Weight
737.76
MOL File
159857-81-5.mol
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Mc-Val-Cit-PABC-PNP Property

Boiling point:
1034.5±65.0 °C(Predicted)
Density 
1.338±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
DMF: 25 mg/ml; DMSO: 20 mg/ml; DMSO:PBS(pH 7.2) (1:4): 0.20 mg/ml
form 
A crystalline solid
pka
13.24±0.70(Predicted)
color 
Off-white to light yellow
InChIKey
UQRQGHMQKAXOTE-DHIFEGFHSA-N
SMILES
C(N)(=O)[C@H](CCCNC(N)=O)N(C(=O)[C@H](C(C)C)NC(=O)CCCCCN1C(=O)C=CC1=O)C1=CC=C(COC(OC2=CC=C([N+]([O-])=O)C=C2)=O)C=C1
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
23881
Product name
Mc-Val-Cit-PABC-PNP
Purity
≥98%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
23881
Product name
Mc-Val-Cit-PABC-PNP
Purity
≥98%
Packaging
5mg
Price
$139
Updated
2024/03/01
Cayman Chemical
Product number
23881
Product name
Mc-Val-Cit-PABC-PNP
Purity
≥98%
Packaging
10mg
Price
$243
Updated
2024/03/01
Iris Biotech GmbH
Product number
ADC1110
Product name
MC-Val-Cit-PAB-PNP
Packaging
250mg
Price
$472.5
Updated
2021/12/16
AK Scientific
Product number
3805AH
Product name
Mc-Val-Cit-PABC-PNP
Packaging
100mg
Price
$594
Updated
2021/12/16
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Mc-Val-Cit-PABC-PNP Chemical Properties,Usage,Production

Description

Mc-Val-Cit-PABC-PNP is a peptide linker molecule used in the synthesis of antibody-drug conjugates (ADCs). It contains a maleimidocaproyl (Mc) group that can be conjugated to an antibody and a p-nitrophenol (PNP) group that allows the peptide to be linked to anticancer compounds, such as doxorubicin or monomethyl auristatin E (MMAE; ). ADCs target specific cell populations to induce a selective response, such as cell death in cancer cells.

Uses

Mc-Val-Cit-PABC-PNP is a cathepsin cleavable ADC linker used in the synthesis of antibody-drug conjugates.

General Description

Mc-Val-Cit-PABC-PNP is chemically known as L-OrnithinaMide, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aMinocarbonyl)-N-[4-[[[(4-nitrophenoxy)carbonyl]oxy]Methyl]phenyl]-, an enzymatically cleavable linker for antibody-drug conjugates (ADCs). Other ADCs linkers include MC-Val-Cit-PAB-PNP, Mc-Val-Ala-PAB-PNP, Mc-Val-Cit-PABOH, and VcMMAE.

Mc-Val-Cit-PABC-PNP Preparation Products And Raw materials

Raw materials

Preparation Products

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Mc-Val-Cit-PABC-PNP Suppliers

Americas 1 Canada 1 China 199 China Hong Kong 1 Europe 1 India 3 Japan 1 United States 16 Global 223
Jinan Chengquan Chemical Co., Ltd
Tel
13616405505 13616405505
Email
zhulinsun1@126.com
Country
China
ProdList
121
Advantage
58
Shenzhen Yuzhong Pharmaceutical Technology Co., Ltd.
Tel
13414494621
Fax
qq: 30307604
Email
chenchao02lzu@126.com
Country
China
ProdList
122
Advantage
58
SuZhou JianHua Pharmaceutical Co. Ltd
Tel
13666392288
Email
jhyylcj@163.com
Country
China
ProdList
64
Advantage
58
Shanghai Send Pharmaceutical Technology Co., Ltd.
Tel
+86-021-50266790 Q2816483246
Fax
021-50266790
Email
sale@shsendpharm.com
Country
China
ProdList
199
Advantage
50
Shanghai Boyle Chemical Co., Ltd.
Tel
Fax
86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2922
Advantage
55
Chembest Research Laboratories Limited
Tel
+86-21-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6005
Advantage
61
Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Fax
021-64823266
Email
chenyj@titansci.com
Country
China
ProdList
14103
Advantage
59
Shanghai Hope Chem Co., Ltd.，
Tel
+21-18501659228 18501659228
Fax
sales@hope-chem.com
Email
info@hope-chem.com
Country
China
ProdList
479
Advantage
55
Shanghai Topbiochem Technology Co., Ltd
Tel
021-58170097
Email
info@topbiochem.com
Country
China
ProdList
9458
Advantage
58
Shenzhen HwaGen Pharmaceutical Co.,Ltd
Tel
18927339850
Fax
0752-5319394
Email
xiaodong.shi@rafflespt.com
Country
China
ProdList
238
Advantage
58
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View Lastest Price from Mc-Val-Cit-PABC-PNP manufacturers

Xian confluore Biological Technology Co., Ltd.
Product
MC-Val-Cit-PAB-PNP 159857-81-5
Price
US $0.00/g
Min. Order
5g
Purity
>97.00%
Supply Ability
5g
Release date
2024-03-29
Henan Fengda Chemical Co., Ltd
Product
L-OrnithinaMide, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aMinocarbonyl)-N-[4-[[[(4-nitrophenoxy)carbonyl]oxy]Methyl]phenyl]- 159857-81-5
Price
US $50.00-1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2023-12-22
Henan Aochuang Chemical Co.,Ltd.
Product
Mc-Val-Cit-PABC-PNP 159857-81-5
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1ton
Release date
2022-09-28

159857-81-5, Mc-Val-Cit-PABC-PNPRelated Search:

SUC-ALA-ALA-PRO-PHE-PNA L-Tryptophan L-Valine methyl ester hydrochloride L-Valine Maleimide

  • L-Ornithinamide
  • Maleimidocaproyl-L-valine-L-citrulline-p-aminobenzyl alcohol p-nitrophenyl carbonate Mc-Val-Cit-PABC-PNP
  • MC-Val-Cit-PABC
  • L-OrnithinaMide, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aMinocarbonyl)-N-[4-[[[(4-nitrophenoxy)carbonyl]oxy]Methyl]phenyl]-
  • Mc-Val-Cit-PABC-PNP
  • MC-VC-PAB-PNP
  • MC-VAL-CIT-PAB-PNB
  • MC-Val-Cit-PAB-PNP
  • Maleimidocaproyl-L-valine-L-citrulline-p-aminobenzyl alcohol p-nitrophenyl carbonate
  • MC-Val-Cit-PAB-PNP (ADC peptide linker)
  • 4-((S)-2-((S)-2-(6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanamido)-3-methylbutanamido)-5-ureidopentanamido)benzyl 4-nitrophenyl carbonate
  • MC-VC-PAB-PNP,Mc-Val-Cit-PABC-PNP
  • MC-VAL-CIT-PABC-PNP;MC-VC-PAB-PNP;MC-VAL-CIT-PAB-PNB;MC-VAL-CIT-PAB-PNP
  • Mc-Val-Cit-PABC-PNP (Maleimidocaproyl-L-valine-L-citrulline-p-aminobenzyl alcohol p-nitrophenyl carbonate)
  • CS-1787
  • Mc-Val-Cit-PABC-PNP(VCMMAE linker)
  • [4-[[(2S)-2-[[(2S)-2-[6-(2,5-dioxopyrrol-1-yl)hexanoylamino]-3-methyl-butanoyl]amino]-5-ureido-pentanoyl]amino]phenyl]methyl (4-nitrophenyl) carbonate
  • N-[6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanoyl]-L-valyl-N5-carbamoyl-N[4-({[(4-nitrophenoxy)carbonyl]oxy}methyl)phenyl]-L-ornithinamide
  • VCMMAE linker
  • JACS-159857-81-5
  • N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aMinocarbonyl)-N-[4-[[[(4-nitrophenoxy)carbonyl]oxy]Methyl]phenyl]-
  • L-OrnithinaMide, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aMinocarbonyl)-N-[4-[[[(5-nitrophenoxy)carbonyl]oxy]Methyl]phenyl]-
  • 4-((S)-2-((S)-2-(6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanamido)-3-methylbutanamido)-5-ureidopentanamido)benzyl 4-nitrophenyl carbonate,linker
  • N-(6-Maleimidocaproyl)-L-valyl-N5-carbamoyl-N-[4-[[[(4-nitrophenoxy)carbonyl]oxy]methyl]phenyl
  • L-OrnithinaMide, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aMinocarbonyl)-N-[4-[[[(4-nitrophenoxy)carbonyl]oxy]Methyl]phenyl]- ISO 9001：2015 REACH
  • SKL361
  • AK-32171
  • [4-[[(2S)-5-(carbamoylamino)-2-[[(2S)-2-[6-(2,5-dioxopyrrol-1-yl)hexanoylamino]-3-methylbutanoyl]amino]pentanoyl]amino]phenyl]methyl (4-nitrophenyl) carbonate
  • 1H-Indene-1,3(2H)-dione,5,8-dichloro-
  • N-[6-(2,5-Dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aminocarbonyl)-N-[4-[[[(4-nitrophenoxy)carbonyl]oxy]methyl]phenyl]-L-ornithinamide
  • Top quality 159857-81-5 MC-Val-Cit-PABC
  • (4-[(2S)-5-(carbamoylamino)-2-[(2S)-2-(6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanamido)-3-methylbutanamido]pentanamido]phenyl)methyl 4-nitrophenyl carbonate
  • Ornithine Impurity 13
  • Inhibitor|||inhibit|||MC-Val-Cit-PABC-PNP|||Maleimidocaproyl-L-valine-L-citrulline-p-aminobenzyl alcohol p-nitrophenyl carbonate|||Maleimidocaproyl-L-valine-L-citrulline-p-aminobenzyl alcohol p-nitrophenyl carbonate|||ADC Linkers|||MC Val Cit PABC PNP|||Antibody-drug conjugate
  • 159857-81-5
  • 159857-81-6
  • C35H43N7O11
  • ADCs Linkers
  • ADCs
  • ADC-Linker
  • ADC-Linkers