Mc-Val-Cit-PABC-PNP
- Product Name
- Mc-Val-Cit-PABC-PNP
- CAS No.
- 159857-81-5
- Chemical Name
- Mc-Val-Cit-PABC-PNP
- Synonyms
- Mc-Val-Cit-PABC-PNP;MC-Val-Cit-PAB-PNP;MC-VC-PAB-PNP;MC-Val-Cit-PABC;L-Ornithinamide;MC-VAL-CIT-PAB-PNB;SKL361;CS-1787;AK-32171;VCMMAE linker
- CBNumber
- CB32667895
- Molecular Formula
- C35H43N7O11
- Formula Weight
- 737.76
- MOL File
- 159857-81-5.mol
Mc-Val-Cit-PABC-PNP Property
- Boiling point:
- 1034.5±65.0 °C(Predicted)
- Density
- 1.338±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- DMF: 25 mg/ml; DMSO: 20 mg/ml; DMSO:PBS(pH 7.2) (1:4): 0.20 mg/ml
- form
- A crystalline solid
- pka
- 13.24±0.70(Predicted)
- color
- Off-white to light yellow
- InChIKey
- UQRQGHMQKAXOTE-DHIFEGFHSA-N
- SMILES
- C(N)(=O)[C@H](CCCNC(N)=O)N(C(=O)[C@H](C(C)C)NC(=O)CCCCCN1C(=O)C=CC1=O)C1=CC=C(COC(OC2=CC=C([N+]([O-])=O)C=C2)=O)C=C1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H303May be harmfulif swallowed
H320Causes eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- M3209
- Product name
- Mc-Val-Cit-PABC-PNP
- Packaging
- 500MG
- Price
- $580
- Updated
- 2025/07/31
- Product number
- 23881
- Product name
- Mc-Val-Cit-PABC-PNP
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 23881
- Product name
- Mc-Val-Cit-PABC-PNP
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $139
- Updated
- 2024/03/01
- Product number
- 23881
- Product name
- Mc-Val-Cit-PABC-PNP
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $243
- Updated
- 2024/03/01
- Product number
- B1003
- Product name
- Mc-Val-Cit-PABC-PNP
- Packaging
- 10mg
- Price
- $200
- Updated
- 2021/12/16
Mc-Val-Cit-PABC-PNP Chemical Properties,Usage,Production
Description
Mc-Val-Cit-PABC-PNP is a peptide linker molecule used in the synthesis of antibody-drug conjugates (ADCs). It contains a maleimidocaproyl (Mc) group that can be conjugated to an antibody and a p-nitrophenol (PNP) group that allows the peptide to be linked to anticancer compounds, such as doxorubicin or monomethyl auristatin E (MMAE; ). ADCs target specific cell populations to induce a selective response, such as cell death in cancer cells.
Uses
Mc-Val-Cit-PABC-PNP is a cathepsin cleavable ADC linker used in the synthesis of antibody-drug conjugates.
General Description
Mc-Val-Cit-PABC-PNP is chemically known as L-OrnithinaMide, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aMinocarbonyl)-N-[4-[[[(4-nitrophenoxy)carbonyl]oxy]Methyl]phenyl]-, an enzymatically cleavable linker for antibody-drug conjugates (ADCs). Other ADCs linkers include MC-Val-Cit-PAB-PNP, Mc-Val-Ala-PAB-PNP, Mc-Val-Cit-PABOH, and VcMMAE.
Synthesis
159857-80-4
5070-13-3
159857-81-5
GENERAL STEPS: To a mixed solution of compound 11 (500 mg, 0.87 mmol) and bis(4-nitrophenyl) carbonate (bis-PNP, 2.64 g, 8.72 mmol) in DCM:DMF (8:2, 25 mL) was added N,N-diisopropylethylamine (DIPEA, 0.45 mL, 2.61 mmol). The reaction mixture was stirred at 23 °C for 20 h. After purification by silica gel column chromatography (eluent: DCM:CH3OH, 50:1 to 10:1), the target product, maleimidohexanoyl-L-valyl-L-citrulline p-aminobenzyl alcohol p-nitrophenyl carbonate 9 (364 mg, 57% yield) was obtained. Thin layer chromatography (TLC) Rf = 0.40 (unfolding agent: CH2Cl2:CH3OH, 9:1).1H NMR (400 MHz, CDCl3/CD3OD) δ 9.45 (s, 1H), 8.23 (d, J = 8.3 Hz, 2H), 7.59 (d, J = 8.5 Hz, 2H), 7.35 (d, J = 8.3 Hz. 2H), 7.34 (d, J = 8.5 Hz, 2H), 6.65 (s, 2H), 5.20 (s, 2H), 4.56 (dt, J = 10.5, 5.4 Hz, 1H), 4.15 (d, J = 7.2 Hz, 1H), 3.46 (dd, J = 8.0, 6.4 Hz, 2H), 3.16-2.89 (m, 2H). 2.21 (dd, J = 8.3, 6.6 Hz, 2H), 2.06-1.97 (m, 1H), 1.90-1.83 (m, 1H), 1.73-1.46 (m, 7H), 1.34-1.20 (m, 2H), 0.91 (d, J = 6.7 Hz, 3H), 0.90 (d, J = 6.7 Hz, 3H).13C NMR (125 MHz, CDCl3/CD3OD) δ 174.4, 172.4, 171.1, 170.6, 160.5, 155.5, 152.5, 145.3, 138.7, 134.1, 129.9, 129.5, 125.2, 121.8, 120.0, 70.6, 59.0, 53.2, 37.5, 35.8, 30.6, 29.6, 29.3, 28.1, 26.2, 25.1, 19.1, 18.1. ESI-MS m/z: Calculated value C34H42N6O11: 737.3; measured value: 738.3 ([M + H]+).
IC 50
Protease Cleavable Linker; Cleavable Linker
References
[1] International Journal of Molecular Sciences, 2017, vol. 18, # 9,
[2] Patent: WO2017/66668, 2017, A1. Location in patent: Paragraph 000199; 000200
[3] Patent: WO2014/191578, 2014, A1. Location in patent: Page/Page column 137-138
[4] Patent: EP2927227, 2015, A1. Location in patent: Paragraph 0051; 0052; 0053; 0054; 0055-0059
[5] Journal of Medicinal Chemistry, 2018, vol. 61, # 3, p. 989 - 1000
Mc-Val-Cit-PABC-PNP Preparation Products And Raw materials
Raw materials
Preparation Products
Mc-Val-Cit-PABC-PNP Suppliers
- Tel
- 00852-68527855
- Fax
- 00852-26406298
- info@itopbiochem.com
- Country
- China Hong Kong
- ProdList
- 902
- Advantage
- 58
View Lastest Price from Mc-Val-Cit-PABC-PNP manufacturers
- Product
- Mc-Val-Cit-PABC-PNP 159857-81-5
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1ton
- Release date
- 2022-09-28
- Product
- MC-Val-Cit-PAB-PNP 159857-81-5
- Price
- US $0.00/g
- Min. Order
- 5g
- Purity
- >97.00%
- Supply Ability
- 5g
- Release date
- 2024-03-29
- Product
- L-OrnithinaMide, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aMinocarbonyl)-N-[4-[[[(4-nitrophenoxy)carbonyl]oxy]Methyl]phenyl]- 159857-81-5
- Price
- US $50.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2023-12-22