Kobe-0065

Product Name: Kobe-0065
CAS No.: 436133-68-5
Chemical Name: Kobe-0065
Synonyms: CS-1281;Kobe0065;Kobe 0065;Kobe-0065;Kobe 0065, >=98%;Kobe0065/Kobe-0065;Kobe0065, 436133-68-5;N-(3-Chloro-4-Methylphenyl)-2-[2,6-dinitro-4-(trifluoroMethyl)phenyl]-hydrazinecarbothioaMide;Hydrazinecarbothioamide, N-(3-chloro-4-methylphenyl)-2-[2,6-dinitro-4-(trifluoromethyl)phenyl]-;Kobe-0065 N-(3-Chloro-4-methylphenyl)-2-[2,6-dinitro-4-(trifluoromethyl)phenyl]hydrazinecarbothioamide
CBNumber: CB32668155
Molecular Formula: C15H11ClF3N5O4S
Formula Weight: 449.79
MOL File: 436133-68-5.mol

More

Less

Kobe-0065 Property

Melting point:: >166°C (dec.)
Boiling point:: 485.1±55.0 °C(Predicted)
Density: 1.653±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,2-8°C
solubility: DMSO: soluble15mg/mL, clear
pka: 9.25±0.70(Predicted)
form: powder
color: white to beige

More

Less

Safety

Hazard Codes: Xn
Risk Statements: 22
WGK Germany: 3

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0961
Product name: Kobe0065
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $94.3
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML0961
Product name: Kobe0065
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $424
Updated: 2022/05/15

Cayman Chemical

Product number: 16261
Product name: Kobe 0065
Purity: ≥98%
Packaging: 1mg
Price: $37
Updated: 2024/03/01

Cayman Chemical

Product number: 16261
Product name: Kobe 0065
Purity: ≥98%
Packaging: 5mg
Price: $90
Updated: 2024/03/01

Cayman Chemical

Product number: 16261
Product name: Kobe 0065
Purity: ≥98%
Packaging: 10mg
Price: $161
Updated: 2024/03/01

More

Less

Kobe-0065 Chemical Properties,Usage,Production

Uses

N-(3-Chloro-4-methylphenyl)-2-[2,6-dinitro-4-(trifluoromethyl)phenyl]-hydrazinecarbothioamide is used in the preparation of pyrazolidine or pyrazole compounds which exhibit mild antimicrobial effects against various strains of bacteria.

Biological Activity

kobe0065 is a small-molecule inhibitor of ras with ki value of 46 μm for the binding of h-ras.gtp to c-raf-1 [1].kobe0065 is a compound screened out by an in silico screen method as a potent inhibitor of the ras–raf interaction. it showed favorite efficacy to inhibit the binding of m-ras.gtp and h-ras.gtp to the ras-binding domain of c-raf-1. kobe0065 also dose-dependently inhibited the binding of h-rasg12v to c-raf-1 in nih 3t3 cells with a rough ic50 value of 10 μm. besides that, 20 μm of kobe0065 effectively suppressed the phosphorylation of down-stream kinases of raf, including mek and erk. in nih 3t3 cells transfected with h-rasg12v, kobe0065 inhibited the colony formation with ic50 value of 0.5 μm. kobe0065 also showed effect on other cancer cells carrying activated ras oncogenes, such as panc-1(k-rasg12v), ht1080 (n-rasq61l) and hct116 (h-rasg13d). moreover, in mice bearing sw480 xenografts, administration of kobe0065 resulted in 40-50% inhibition of the tumor growth at dose of 80 mg/kg. this effect turned to be more distinct when the dose was up to 160 mg/kg [1].

References

[1] shima f, yoshikawa y, ye m, et al. in silico discovery of small-molecule ras inhibitors that display antitumor activity by blocking the ras–effector interaction. proceedings of the national academy of sciences, 2013, 110(20): 8182-8187.

Kobe-0065 Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

Kobe-0065 Suppliers

Canada 1 China 74 India 1 The Netherlands 1 United Kingdom 2 United States 13 Global 92

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32321
Advantage: 50

Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
ProdList: 7552
Advantage: 61

MedChemexpress LLC

Tel: 021-58955995
Fax: 609-228-5909
Email: sales@medchemexpress.cn
Country: United States
ProdList: 4861
Advantage: 58

AdooQ BioScience, LLC

Tel: +1 (866) 930-6790
Fax: +1 (866) 333-9607
Email: info@adooq.com
Country: United States
ProdList: 2782
Advantage: 58

Shanghai TaoSu Biochemical Technology Co., Ltd.

Tel: 021-33632979
Fax: 021-34692979
Email: info@tsbiochem.com
Country: China
ProdList: 8065
Advantage: 58

AdooQ Bioscience CHINA

Tel: 025-58849295 18951903616;
Fax: 025-68650336
Email: info@adooq.cn
Country: China
ProdList: 2990
Advantage: 60

Shanghai JiYi Biotechnology Co. Ltd.

Tel: 13621943973
Fax: -
Email: sales@shjiyipharmatech.com
Country: China
ProdList: 1166
Advantage: 55

LETOPHARM LIMITED

Tel: +86-21-5821 5861
Fax: +86-21-5106 2861
Email: sales@letopharm.com
Country: China
ProdList: 2384
Advantage: 58

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4573
Advantage: 55

More

Less

View Lastest Price from Kobe-0065 manufacturers

Career Henan Chemical Co

Product: Kobe-0065 436133-68-5
Price: US $1.00/g
Min. Order: 100g
Purity: 99%
Supply Ability: G/KG/T
Release date: 2019-12-20

436133-68-5, Kobe-0065Related Search:

2-Cyclopropyl-4-(4-fluorophenyl)-quinolyl-3-methanol N,N'-Ethylenebis(stearamide) Deionized water (2R,3S/2S,3R)-3-(4-Chloro-5-fluoro-6-pyrimidinyl)-2-(2,4-difluorophenyl)butan-2-ol hydrochloride

Kobe 0065

Kobe0065

Kobe-0065

N-(3-Chloro-4-Methylphenyl)-2-[2,6-dinitro-4-(trifluoroMethyl)phenyl]-hydrazinecarbothioaMide

Kobe0065, 436133-68-5

Kobe0065/Kobe-0065

Kobe-0065 N-(3-Chloro-4-methylphenyl)-2-[2,6-dinitro-4-(trifluoromethyl)phenyl]hydrazinecarbothioamide

N-(3-Chloro-4-methylphenyl)-2-[2,6-dinitro-4-(trifluoromethyl)phenyl]hydrazinecarbothioamide KOBE0065

Kobe 0065, >=98%

CS-1281

Hydrazinecarbothioamide, N-(3-chloro-4-methylphenyl)-2-[2,6-dinitro-4-(trifluoromethyl)phenyl]-

436133-68-5

C15H11ClF3N5O4S

Inhibitors

Aromatics, Miscellaneous Reagents, Pharmaceuticals, Intermediates & Fine Chemicals