ChemicalBook > CAS DataBase List > diMethyl lithosperMate B

diMethyl lithosperMate B

Product Name: diMethyl lithosperMate B
CAS No.: 875313-64-7
Chemical Name: diMethyl lithosperMate B
Synonyms: dmLSB;diMethyl lithosperMate B;Lithospermic acid B dimethyl ester;Dimethyl lithospermate B, 10 mM in DMSO;(R)-3-(3,4-Dihydroxyphenyl)-1-methoxy-1-oxopropan-2-yl (2S,3S)-2-(3,4-dihydroxyphenyl)-4-((E)-3-(((R)-3-(3,4-dihydroxyphenyl)-1-methoxy-1-oxopropan-2-yl)oxy)-3-oxoprop-1-en-1-yl)-7-hydroxy-2,3-dihydrobenzofuran-3-carboxylate;3-Benzofurancarboxylic acid, 2-(3,4-dihydroxyphenyl)-4-[(1E)-3-[(1R)-1-[(3,4-dihydroxyphenyl)methyl]-2-methoxy-2-oxoethoxy]-3-oxo-1-propen-1-yl]-2,3-dihydro-7-hydroxy-, (1R)-1-[(3,4-dihydroxyphenyl)methyl]-2-methoxy-2-oxoethyl ester, (2S,3S)-
CBNumber: CB32672934
Molecular Formula: C38H34O16
Formula Weight: 746.67
MOL File: 875313-64-7.mol

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diMethyl lithosperMate B Property

Boiling point:: 968.3±65.0 °C(Predicted)
Density: 1.525±0.06 g/cm3(Predicted)
storage temp.: -20°C, protect from light
solubility: Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form: Powder
pka: 9.43±0.60(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0027920
Product name: DimethyllithospermateB
Packaging: 5mg
Price: $686
Updated: 2021/12/16

AvaChem

Product number: 3493
Product name: Dimethyl lithospermate B
Packaging: 1mg
Price: $190
Updated: 2021/12/16

JR MediChem

Product number: JR8-N1290
Product name: DimethyllithospermateB(NewProduct)
Purity: 98%(HPLC)
Packaging: 20mg
Price: $258
Updated: 2021/12/16

AvaChem

Product number: 3493
Product name: Dimethyl lithospermate B
Packaging: 5mg
Price: $290
Updated: 2021/12/16

AvaChem

Product number: 3493
Product name: Dimethyl lithospermate B
Packaging: 10mg
Price: $390
Updated: 2021/12/16

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diMethyl lithosperMate B Chemical Properties,Usage,Production

Chemical Properties

White crystalline powder, soluble in organic solvents such as methanol, ethanol, DMSO, etc., derived from Salvia miltiorrhiza.

Uses

Dimethyl lithospermate B (dmLSB) is a selective Na+ channel agonist. Dimethyl lithospermate B slows inactivation of sodium current (INa), leading to increased inward current during the early phases of the action potential (AP)[1][2].

target

Calcium Channel | Sodium Channel | Potassium Channel

References

[1] Fish JM, et al. Dimethyl lithospermate B, an extract of Danshen, suppresses arrhythmogenesis associated with the Brugada syndrome. Circulation. 2006 Mar 21;113(11):1393-400. DOI:10.1161/CIRCULATIONAHA.105.601690
[2] Yoon JY, et al. A novel Na+ channel agonist, dimethyl lithospermate B, slows Na+ current inactivation and increases action potential duration in isolated rat ventricular myocytes. Br J Pharmacol. 2004 Nov;143(6):765-73. DOI:10.1038/sj.bjp.0705969

diMethyl lithosperMate B Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from diMethyl lithosperMate B manufacturers

Shanghai Standard Technology Co., Ltd.

Product: Dimethyl lithospermate B 875313-64-7
Price: US $0.00/mg
Min. Order: 5mg
Purity: ≥98%(HPLC)
Supply Ability: 10 g
Release date: 2020-04-28

Career Henan Chemical Co

Product: diMethyl lithosperMate B 875313-64-7
Price: US $9.80/KG
Min. Order: 1KG
Purity: ≥98%
Supply Ability: 20 tons
Release date: 2020-01-10

875313-64-7, diMethyl lithosperMate BRelated Search:

Tanshinone IIA 9'''-MethyllithosperMate B magnessium lithospermate B Sodium danshensu 7-Ethyl-10-hydroxycamptothecin Salvianolicacid C 9'''-MethyllithosperMate B TanshinoneIIA 3-(3,4-dihydroxyphenyl)-2-hydroxy-propanoic acid Salvianolic acid Paeonol Sodium Paeonolsilate Salvianolic acid lithospermic acid B

diMethyl lithosperMate B

Lithospermic acid B dimethyl ester

dmLSB

3-Benzofurancarboxylic acid, 2-(3,4-dihydroxyphenyl)-4-[(1E)-3-[(1R)-1-[(3,4-dihydroxyphenyl)methyl]-2-methoxy-2-oxoethoxy]-3-oxo-1-propen-1-yl]-2,3-dihydro-7-hydroxy-, (1R)-1-[(3,4-dihydroxyphenyl)methyl]-2-methoxy-2-oxoethyl ester, (2S,3S)-

(R)-3-(3,4-Dihydroxyphenyl)-1-methoxy-1-oxopropan-2-yl (2S,3S)-2-(3,4-dihydroxyphenyl)-4-((E)-3-(((R)-3-(3,4-dihydroxyphenyl)-1-methoxy-1-oxopropan-2-yl)oxy)-3-oxoprop-1-en-1-yl)-7-hydroxy-2,3-dihydrobenzofuran-3-carboxylate

Dimethyl lithospermate B, 10 mM in DMSO

875313-64-7

C38H34O16

Phenylpropanoids

chemical reagent

pharmaceutical intermediate

phytochemical

reference standards from Chinese medicinal herbs (TCM).

standardized herbal extract